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Background: Patients with cyanotic congenital heart disease (CCHD) may have a low burden of atherosclerosis. Endothelial dysfunction is an early stage of atherosclerosis and endothelial function is previously studied in smaller CCHD groups with different techniques and variable results. We aimed to examine endothelial function and carotid atherosclerosis in a larger group of CCHD patients. Methods
År 2008 brakade den finansiella marknaden samman och följdes av en recession världen över som vi till viss del fortfarande brottas med. OTC-derivat, ett skräddarsytt bilateralt finansiellt instrument, har i finanskrisens efterdyningar beskyllts vara en av bovarna i dramat. Särskilt tros OTC-derivaten ha bidragit till en icke-transparens på marknaden som gjorde det omöjligt att både förutse och förIn 2008 the financial market collapsed and what followed was a worldwide recession which the market has yet to fully recover from. OTC-derivatives, which are tailor-made bilateral financial instruments, have in the aftermath of the collapse been accused of being one of the culprits. More specifically, OTC-derivatives are believed to have contributed to the opaque financial market that made it impo
Sverige har en lång tradition av en flexibel arbetsmarknad där arbetstagare fritt kunnat förflytta sig mellan offentlig och privat sektor. Övergångar av detta slag är i många delar positivt och genererar ett erfarenhetsutbyte som är till gagn för båda sektorer. I samband med övergång från anställning i offentlig till privat verksamhet kan emellertid så kallad svängdörrsproblematik uppstå. Denna prSweden has a long tradition of a flexible labor market where employees have been able to freely move between the public and private sectors. Transitions of this kind are largely positive and generate an exchange of experience that benefits both sectors. However, transitions from employment in the public sector to the private sector can give rise to what is known as the revolving door problem. This
The Swedish age of criminal responsibility means that children under 15 who commit offences cannot be sentenced to any penalty. There is, however, a process in § 38 LUL that can determine whether a child under 15 has commit-ted a serious crime, called an evidentiary proceeding. At the time of its crea-tion, the purpose of an evidentiary proceeding was to provide the child wel-fare authorities with
On July 22, 2022, a crown witness system was introduced with the aim of increasing prosecution rates and breaking the prevailing culture of silence. This system includes a basis for sentence reduction regarding participation in the investigation of another's criminal activity. The idea behind the crown witness system is to increase incentives for suspects to cooperate in order to solve more se
On 1 July 2022, the Swedish Act (1988:254) on the Prohibition of Knives and Other Dangerous Objects (the Swedish Knife Act), which criminalizes possession of knives and other dangerous objects in public places, was amended. Through the amendment, four criteria were introduced to the statutory text, which are to be given particular consideration when assessing whether a violation of the law is to b
Idag återfinns sexistiska kommentarer på sociala medieplattform, trots att företagen bakom har regler för vad som får publiceras. Sexism är ett strukturellt problem som kan påverka kvinnor negativt, både fysiskt och psykiskt och kan leda till självcensur. Ge- nom en kvalitativ textanalys syftar denna uppsats att testa om tre principer kan användas för att analysera om sexistiska kommentarer från FToday, sexist comments can be found on social media platforms, despite social media companies having rules on what is allowed to be published. Sexism is a structural prob- lem which can negatively affect women, both physically and mentally, and could lead to self-censorship. Through a qualitative text analysis, this essay aims to investigate whether sexist comments from Facebook and Instagram are
On July 1 this year, a new crime for involving a minor in crime will be introduced in Chapter 16, Section 5 a of the Swedish Penal Code. In the government bill, the purpose of the new criminalization is described as protecting society from young people being drawn into criminal networks. For a penal provision to be considered justified, there are several criminalization principles to which it mus
Until July 1, 2018, Swedish legislation lacked a general remedy for delays in the authorities’ handling of cases. With the introduction of section 12 of the Public Administration Act the remedy, often referred to as the delay action, came to change the Swedish Migration Agency’s routine handling of citizenship applications. Authorities would henceforth not be able to act passively in the handling
On the first of July 2018, Sweden made a drastic change to its rape provision, by adopting a new legislation, commonly referred to as the ”Consent Law”. Sweden’s neighboring country, Denmark, adopted its own version of the Consent Law a couple of years later, on the first of January 2021. The newely change of the Swedish and Danish penal codes have been an important step torwards reducing rap
Background Problematic Internet use is characterized by excessive use of online platforms that can result in social isolation, family problems, psychological distress, and even suicide. Problematic Internet use has been associated with cannabis use disorder, however knowledge on the adult population remains limited. In Quebec, cannabis use has significatively increased since 2018, and it is associ
Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation
Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con
The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib
We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a -blocker strategy or a calcium channel blocker strategy. Genom
Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (
