This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the benefits and harms associated with weight loss in overweight individuals with knee or hip osteoarthritis in terms of pain, physical function, quality of life, and safety. Further we will have an explicit focus on quality of the weight loss intervention (including magnitude and intensity) (Herbe

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tol

Single nucleotide polymorphisms (SNPs) in various genes have been shown to associate with COPD, suggesting a role in disease pathogenesis. Sulfatase modifying factor (SUMF1) is a key modifier in connective tissue remodelling, and we have shown previously that several SNPs in SUMF1 are associated with COPD. The aim of this study was to investigate the association between SUMF1 SNPs and advanced l

Promoter methylation is a common phenomenon in tumours, including haematological malignancies. In the present study, we investigated 36 cases of high hyperdiploid (> 50 chromosomes) acute lymphoblastic leukaemia (ALL) with methylation-specific multiplex ligase-dependent probe amplification to determine the extent of aberrant methylation in this subgroup. The analysis, which comprised the promoters

Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with

Popular Abstract in Danish Omkring halvdelen af den globale kulstof mængde som findes i jorden, er lagret i de arktiske jorde. Arktiske jorde har været anset for at være vigtige kulstof reservoirs de sidste 10.000 år, hvor der bliver optaget mere kulstof end der frigives. Dette skyldes blandt andet den langsomme omsætning af organiske materiale på grund af de kolde forhold, men også de store mængdArctic ecosystems hold massive amounts of the global carbon in their soils and are of great importance for the global terrestrial exchange of greenhouse gases to the atmosphere. The arctic region has in general been acting as a C sink for the past 10000 years, however with climate change the C balance in some areas is shifting towards becoming a C source. Herbivory are an important part of many ec

The World Health Organization (WHO) classification of myeloid leukaemia was revised in 2008. It incorporates newly recognized entities and emphasizes the pivotal role of cytogenetic abnormalities. The aim of this study was to evaluate the usability of the WHO classification when applied to a large population-based paediatric acute myeloid leukaemia (AML) cohort. We included children diagnosed with

Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (

Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t

OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal

OBJECTIVE: This study utilized the evidence-gap map method and critically examined the scope, methodologies, and focus of the studies that investigated the influence of the built environment on inpatient healthcare settings over a decade (2010-2021).METHODS: We conducted a systematic review per the preferred reporting items for systematic reviews and meta-analyses guidelines and surveyed 406 artic

Animals across phyla can detect early cues of infection in conspecifics, thereby reducing risk of contamination. It is unknown, however, if humans can detect cues of sickness in people belonging to communities with whom they have limited or no experience. To test this, we presented Western faces photographed two hours after the experimental induction of an acute immune response to one Western and

Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database

En studie av den medicinska dokumentationen i läkarsekreterarens yrkesvärld.  2006Studien beskriver läkarsekreterarens yrkesroll i historiskt perspektiv från 1919 när den första läkarsekreteraren anställdes i landet.Målsättningen var att belysa den medicinska dokumentationens betydelse i historiskt perspektiv.En studie av Nils Rosén von Rosensteins avhandling av år 1730.  2006En minnesskrift med a

https://www.medicinhistoria.lu.se/inga-nilsson - 2025-02-11

2005-2006 Pedro Barateiro                                            http://the-sad-savages.tumblr.com/ Anna Bokström  Helene Edgren Rebecka Hallbert Andreas Johansson Mathias Kristersson Christina Leithe Hansen Carl Lindh Trygve Luktvasslimo                                  http://trygveluktvasslimo.com/ Nicklas Malmlöf Bryntesson Kevin Murphy Mattias Nordéus Anders Sletvold Moe                  

https://www.khm.lu.se/om-konsthogskolan/alumn/2005-2014 - 2025-02-11

A Discussion about "Twenty Springs" at Malmö Konsthall Berlin-based Sono-Choreographic Collective discuss their sound installation Twenty Springs, happening in parallel at Malmö Konsthall from Wednesday, October 18th to Sunday, October 22nd, 2023. They will discuss methods of artistic research, and how they turned 20 years of environmental data into a 60-minute installation. The discussion will al

https://www.lmc.lu.se/how-artistic-researchers-are-sonifying-climate-data - 2025-02-11

När du ska köpa in varor eller tjänster till ett värde av mellan 700 000 kronor och 1 546 202 kronor och inga existerande avtal finns ska du göra en annonspliktig upphandling under tröskelvärdet. På denna sida hittar du information om hur du ska göra. Vem ska göra upphandlingen?Om du genomför köpet för MAX IV ska du inte genomföra köpet själv utan kontakta avdelningen Inköp och upphandling som gen

https://www.medarbetarwebben.lu.se/stod-och-verktyg/inkop-faktura-ekonomi/inkop-och-upphandling/annonspliktig-upphandling-under-troskelvardet - 2025-02-11

Äldreomsorgens komplexa verklighet behöver studeras med en mängd olika metoder och tillvägagångssätt, med fokus på strukturella, interpersonella och personliga aspekter och med hänsyn till perspektiven hos de som får vård och de som ger vård. Socialhögskolans äldregrupp har sitt ursprung i ”VoV-gruppen” (omsorgens vardag och villkor) som professor Rosmari Eliasson-Lappalainen startade 1993. Äldreg

https://www.soch.lu.se/forskning/forskningsomraden/aldre-och-aldrande - 2025-02-11