Early transcriptional states of spermatogonia and marker expressions in the prepubertal human testis following chemotherapy-induced depletion
STUDY QUESTION Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? SUMMARY ANSWER Single-cell transcriptomic analysis reveals that only undifferentiated spermatogonia are present in prepubertal boys, while differentiated states emerge during puberty, w
