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In the presence of excess hydrogen peroxide (H2O2), ferrous (Fe(+2)) human hemoglobin (Hb) (α2β2) undergoes a rapid conversion to a higher oxidation ferryl state (Fe(+4)) which rapidly autoreduces back to the ferric form (Fe(+3)) as H2O2 is consumed in the reaction. In the presence of additional H2O2 the ferric state can form both ferryl Hb and an associated protein radical in a pseudoperoxidative

The increasing size of the population results in that unbuilt spaces needing to be used for the construction of new facilities. Large construction sites can generate disturbing vibrations to nearby buildings, both while construction is underway and afterwards through the operation of subways, for example. The establishment of new areas close to, for example, motorways and railways increases the ri

Homogeneous Charge Compression Ignition (HCCI) is a promising internal combustion engine concept. It holds promise of combining low emission levels with high efficiency. However, as ignition timing in HCCI operation lacks direct actuation and is highly sensitive to operating conditions and disturbances, robust closed-loop control is necessary. To facilitate control design and allow for porting of

The work presented here is based on two papers, both pertaining to perturbation-based control strategies in industrial fed-batch fermentation processes. The first paper describes a new control strategy for avoiding overflow metabolism in the exponential growth phase of a fermentation, based on analysis of the frequency spectrum of the dissolved oxygen measurement following a periodic perturbation

Popular Abstract in Swedish Varje år insjuknar omkring 300 barn i cancer. Förbättrade behandlingsmetoder under de senaste decennierna har lett till att mer än tre av fyra barn idag faktiskt botas från sin sjukdom. Tyvärr drabbas en stor andel av de som överlever sin cancer av så kallade sena komplikationer till följd av den tuffa behandling de har utsatts för. Bland annat har man sett en livslång The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. Growing evidence indicates that patients with genetic susceptibilit

Background: In adults, impaired myocardial repolarization and increased risk of arrhythmia are known consequences of open heart surgery. Little is known, however, about post-operative consequences of cardiopulmonary bypass surgery in children. The aim of this study was to assess ventricular repolarization and coronary perfusion after bypass surgery for atrial septal defect (ASD) repair in children

Spelifiering inom utbildning är ett väldigt aktuellt ämne idag och det pågår mycket forskning och många projekt för att undersöka hur spel främjar lärande.

Religionssociologi är ett brett ämnesområde som belyser de sociala funktionerna av religion i dåtid likväl som i nutid. En av de nutida viktiga aspekterna av religionens sociala natur är dess förhållande till etnicitet. Etnicitet har under den senare delen av 1900-talet varit ett framträdande sätt att kategorisera grupper. Samtidigt har det framförts tankar om att denna form av social kategoriseri

Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall objective of this thesis was to develop a new assessment method of efficacy of biological therapy in clin

Foreword to the publication.

The 24th of April 2015 will mark the centennial commemoration of the Armenian genocide and is expected to be a worldwide ceremony. Hundred years will have passed since the start of the state orchestrated massacres and deportations in 1915 which emptied the majority of historical Armenia from its native population. A century has passed, but ironically, the Armenian genocide seems to become more top

Because of its existential character, organ transplantation is strongly connected to a person's view of life. This article describes how participants in a focus group use religious elements in decision-making on transplantation medicine in four European countries. Further these findings are related to two influential theologians: James Gustafson and Paul Ramsey, and their thinking on the role of r

In this paper a modified two-dimensional Luikov model for evaluating the non-isothermal moisture migration in porous building materials was proposed. The coupled heat and moisture transfer problem was modeled. Vapor content and temperature were chosen as the principal driving potentials. The coupled equations were solved by a numerical method, which consists of a finite difference technique with a

Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which r

The Mobile Service Support system (MSS), which Ericsson AB develops, handles the setup of new subscribers and services into a mobile network. Experience from deployed systems show that traffic monitoring and control of the system will be crucial for handling overload situations that may occur at sudden traffic surges. In this paper we identify and explore some important control challenges for this

Disperse dyes are the most common allergens among textile dyes. It is not known whether the purified dyes, impurities in the commercial dyes, or metabolites are the actual sensitisers. Moreover, it is not known whether those disperse dyes that are now present in test series are actually used in textile dyeing today. The aim of this thesis was A) to evaluate the significance of the impurities foun

Popular Abstract in Swedish Allt fler människor drabbas av cancer, som idag är den ledande dödsorsaken globalt. De vanligaste cancerformerna i världen är lungcancer, bröstcancer och tjocktarmscancer och det är störst risk att dö i lungcancer, levercancer och magcancer. Även i Sverige ökar antalet cancerfall, till stor del på grund av att vi lever allt längre och cancer är idag en av våra stora folCancer incidence is increasing and it is the number one cause of death worldwide. Cancer is a highly heterogeneous disease and there is a great need for new early diagnostic, prognostic and treatment predictive biomarkers in order to improve patient outcomes. The RNA-binding motif protein 3, RBM3, is an emerging candidate biomarker of favourable prognosis and treatment response in several types of