Epigenetic regulation of Cancer Testis Antigens: candidate drivers of genomic instability in Triple Negative Breast Cancer
Cancer Testis (CT) genes are restrictedly expressed in immune-privileged germ tissues and recognised as non-self antigens if aberrantly reactivated in tumours. Beyond their immunotherapeutic potential, certain CT genes have known oncogenic roles, reflecting highly specialised physiological functions in the germline. Meiosis-associated CT genes have been implicated as drivers of genomic instability
