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Background: The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. However, a placebo control is a complex type of comparison group in the surgical setting and, although powerful, presents many challenges. Objectives: To provide a summary of knowledge on placebo controls in surgical trials and to summarise any recomme

BACKGROUND: Lymph node metastasis is the single most important prognostic risk factor for recurrence in patients with colon cancer who have undergone curative surgery. The routine method for detecting disseminated tumor cells in lymph nodes is microscopic examination of one or a few hematoxylin and eosin-stained tissue sections by a trained pathologist. This method, however, is insensitive mainly

A sustainability index (SI) is a benchmark for guiding the activities of municipal water and wastewater (W and WS) utilities toward sustainability. The SI has been used in Sweden since 2014 as an internal benchmark management tool facilitating the strategic work of organizations. This study assesses how the SI was applied in practice by eight utilities (Orgs 1–8) from 2015 to 2019. The study was p

The variabilities in rainfall and temperature in a catchment affect water availability and sustainability. This study assessed the variabilities in rainfall and temperature (1981–2015) and river flow (1998–2015) in the Sipi sub-catchment on annual and seasonal scales. Observed daily rainfall and temperature data for Buginyanya and Kapchorwa weather stations were obtained from the Uganda National M

Background: Children diagnosed with right ventricle outflow tract (RVOT) anomalies require surgical repair early in life, reoperations and lifelong follow-up. The aim is to comprehensively describe their health related quality of life (HRQoL) and to assess the agreement in this regard between children and parents. Methods and Results: Child- and parent-reported HRQoL was assessed in 97 children ag

Organizations grow and excel with knowledge sharing; on the other hand, knowledge hiding is a negative behavior that impedes innovation, growth, problem solving, and timely correct decision making in organizations. It becomes more critical in the case of teaching hospitals, where, besides patient care, medical students are taught and trained. We assume that negative emotions lead employees to hide

Eunuchs and members of the transgender community are yet to be recognized as an effective human resource and this diversity in the workforce is still invisible. A tiny portion of the transgender community is employed, and they are tagged as purple collar employees. It is generally claimed that coworkers do not accept members of the transgender community in the workplace and are not willing to work

The presence of hazardous materials hinders the circular economy in construction and demolition waste management. However, traditional environmental investigations are costly and time-consuming, and thus lead to limited adoption. To deal with these challenges, the study investigated the possibility of employing registered records as input data to achieve in situ hazardous building materials manage

Iran is mainly located in the arid and semiarid climate zone and seriously affected by desertification. This is a severe environmental problem, which results in a persistent loss of ecosys-tem services that are fundamental to sustaining life. Process understanding of this phenomenon through the evaluation of important drivers is, however, a challenging work. The main purpose of this study was to p

Business models direct a firm’s activity to move in coherence with the objectives of the business. Current literature suggests business models can act as vital forces to facilitate sustain-ability transitions and highlights the urgent research call to understand the role of business model innovations in stimulating sustainability transitions. This paper addresses this research need by investigatin

Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we used dynamic contrast-enhanced magnetic resonance imaging to assess meningeal lymphatic flow in cognitively normal controls and patients with idi

Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. Approaches based on biochemical fractionation of intact, native complexes and correlation of protein profiles have shown promise. However, most approaches for interpreting cofractionation datasets to yield complex composition and rearrangements betwee

Root exudates can significantly modify microbial activity and soil organic matter (SOM) mineralization. However, how root exudates and their C/N stoichiometric ratios control paddy soil C mineralization is poorly understood. This study used a mixture of glucose, oxalic acid, and alanine as root exudate mimics for three C/N stoichiometric ratios (CN6, CN10, and CN80) to explore the underlying mecha

We present Higher Order Mode (HOM) studies on ESS Medium-Beta cavity, designed in INFN-LASA, including both simulation and measurement results. Mechanical tolerances of the fabrication process might shift HOMs frequencies toward harmonics of the bunch frequency. Both simulation and measurements at room and cryogenic temperature show that the design is fully compatible to requirements.