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A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This ''protein-centric" view is increasingly challenged by evidence for the involvement of specialized membrane domains in signal transduction. Here, we propose that membrane perturbation may serve as an alternative mechanism to

To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).

The PHENIX experiment at RHIC has measured and ω meson production in p+p, d+Au and Au+Au collisions for GeV at mid-rapidity. Systematic measurements of light vector mesons for several decay channels provide information about properties of the strongly interacting matter produced in relativistic heavy-ion collisions. We present transverse momentum spectra and nuclear modification factors for and ω

Clays are of paramount importance for soil stability, but also in applications ranging from oil recovery to composites and hydrogels. Generically, clays are divided into two subclasses: macroscopically swelling, ‘active’ clays that have the capacity for taking up large amounts of water to form stable gels, and ‘passive’ or non-swelling clays; the former stabilize soils whereas the latter are known

Popular Abstract in Swedish Mesenkymala stamceller (MSC) kan isoleras från en rad olika vävnader i kroppen, bland annat från benmärg. De kan differentiera till ben, brosk, fett- och bindvävnad men deras exakt roll i kroppen är inte väl känd. Den senaste forskningen tyder dock på att en av deras huvuduppgifter är att stödja blodbildningen som sker av blod- eller hematopoetiska stamceller. Man Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. MSC cultures however, are heterogeneous and, while critical for clinical applications, their exact composition is not known. W

This paper analyzes the role of initialization when testing for a unit root in panel data, an issue that has received surprisingly little attention in the literature. In fact, most studies assume that the initial value is either zero or bounded. As a response to this, the current paper considers a model in which the initialization is in the past, which is shown to have several distinctive features

We demonstrate high-resolution tunable diode laser absorption spectroscopy (TDLAS) of water vapor confined in nanoporous alumina. Strong multiple light scattering results in long photon pathlengths (1 m through a 6 mm sample). We report on strong line broadening due to frequent wall collisions (gas-surface interactions). For the water vapor line at 935.685 nm, the HWHM of confined molecules are ab

Background 3-Hydroxypropionic acid (3HP) and acrylic acid (AA) are industrially important platform- and secondary chemical, respectively. Their production from renewable resources by environment-friendly processes is desirable. In the present study, both chemicals were almost quantitatively produced from biodiesel-derived glycerol by an integrated process involving microbial and chemical catalysis

A new genus, Catenarina (Teloschistaceae, Ascomycota), with three species is described from the Southern Hemisphere, supported by molecular data. All species contain the secondary metabolite 7-chlorocatenarin, previously unknown in lichens. Catenarinadesolata is a non-littoral, lichenicolous species found on volcanic and soft sedimentary rock at 190-300 m in and near steppes in southernmost Chile

Windows in a package is a common way to promote the product. The possibility to predict the collapse load for these types of cartonboard packages is considered. It is shown that reliable estimates of the collapse loads can be obtained by a very simple approach. This approach is a straightforward generalization of the proposal by Ristinmaa et al. (2012): for a side that contains a window, one simpl

Critical evaluation of the World Missionary Conference, Edinburgh 1910, from the perspective of later 20th century developments in Christian mission and ecumenism, with special attention to the global South and postcolonial analysis.

Lipid-binding proteins Sequester amphiphilic molecules in a large internal : cavity occupied by similar to 30 water molecules, some of which are displaced by the ligand. The role; of these internal water molecules in lipid binding and release is not understood. We use magnetic relaxation dispersion (MRD) to directly monitor internal-water dynamics in apo and palmitate-bound rat intestinal fatty ac

Mothers (N= 35) and their adult children completed questionnaires and were interviewed in order to examine relationships between mothers' caregiving representations and their adult children's attachment representations, and relationships between attachment/caregiving representations and beliefs about mothering. Mothers' and their children's accounts of and present thinking about their past relatio

Converting elemental mercury into divalent compound is one of the most important steps for mercury abatement from coal fired flue gas. The oxidation of elemental mercury was investigated in this paper using dielectric barrier discharge (DBD) non-thermal plasma (NTP) technology at room temperature. Effects of different flue gas components like oxygen, moisture, HCl, NO and SO2 were investigated. Re

The ideal free distribution (IFD) model predicts that consumers match the distribution of resources across habitat patches and that this association should lead to equal individual fitness among individuals in a population. Here we studied to what extent predators utilize different prey groups and if the resulting spatial patterns relate to the reproductive success of individuals in a population o