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In clinical genetic diagnostics, it is difficult to predict whether genetic mutations that do not greatly alter the primary sequence of the encoded protein causing unknown functional effects on cognate proteins lead to development of disease. Here, we report the clinical identification of c.2038 T>C missense mutation in exon 18 of the human MLH1 gene and biochemically characterization of the p.Cys
Global environmental change and increasing human population emphasize the urgent need for higher yielding and better adapted crop plants. One strategy to achieve this aim is to exploit the wealth of so called landraces of crop species, representing diverse traditional domesticated populations of locally adapted genotypes. In this study, we investigated a comprehensive set of 1485 spring barley lan
The testis is a radiosensitive tissue. It contains a large number of lobules, which in turn are composed of convoluted seminiferous tubules. The epithelium inside each tubule consists of a complex mosaic of supporting cells and germ cells of different sizes and degrees of maturation. These cells are known to have diverse sensitivity to radiation, those with the highest sensitivity being the sperma
Glucagon-like peptide 1 (GLP-1) augments glucose-stimulated insulin secretion (GSIS) through cAMP-induced activation of protein kinase A (PKA), and stimulates beta-cell proliferation and reduces beta-cell apoptosis in rodent islets. This study explored islet GSIS, PKA expression, and markers of apoptosis (caspase 3/7 activity) and proliferation (PKBalpha and pancreatic and duodenal homeobox gene 1
This thesis explores the external debt situation of developing countries and donor responses in terms of aid composition and debt relief. Primarily, these issues are important for future debt sustainability and therefore for creating beneficial conditions for accelerating growth and reducing poverty. With a focus on domestic factors (e.g. regime type) and exogenous shocks (e.g. terms of trade vol
A convolutional code can be used to detect or correct infinite sequences of errors or to correct infinite sequences of erasures. First, erasure correction is shown to be related to error detection, as well as error detection to error correction. Next, the active burst distance is exploited, and various bounds on erasure correction, error detection, and error correction are obtained for convolution
Regular column on performing arts in the weekly newspaper Arbetaren (The Worker).
In atrial fibrillation (AF), the body surface signal pattern varies considerably from one patient to another as well as over time. We have developed a new method for ECG-based characterization of AF which explores the morphology of the f-waves. Following QRST cancellation, the method divides the atrial signal into short blocks and performs a model-based analysis of each block. The blocks are then
The climate conditions inside nuclear reactor containments depend on several parameters e.g. different moisture and heat sources; the containment design; material properties etc. Knowledge about the climatic condition is an important area to e.g. maintain a proper condition for mechanical and electrical equipment; minimize the corrosion risks of reinforcement and metallic components; prevent vapor
Popular Abstract in Swedish Nästan 35% av den totala avrinningen i Gula floden härstammar från dess källområde och vattenförsörjningen nedströms är därför beroende av de rådande förhållandena i detta område. Minskad vattenföring i floden på grund av klimatförändringar förväntas leda till negativa konsekvenser för de 110 miljoner invånarna i avrinningsområdet och problem uppstår för såväl jordbrukeThe source region of the Yellow River contributes about 35% of the total water yield in the Yellow River basin playing an important role for meeting the downstream water resources requirements. The declining water availability caused by climate change in the source region of the Yellow River is expected to have severe repercussions for the 110 million basin inhabitants in terms of water resources
