Cell stressors, such as elevated levels of reactive oxygen species (ROS), adversely affect hematopoietic stem cell (HSC) reconstituting ability. However, the effects of ROS have not been evaluated in the context of hematopoietic development from human pluripotent stem cells (hPSCs). Using our previously described in vitro system for efficient derivation of hematopoietic cells from hPSCs, we show t

Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory

Pilot control globe valve (PCGV) can use the pressure difference produced by fluid itself to realize the opening and closing states with a pilot valve. In this paper, numerical method is used to investigate the fluid flow characteristics and the valve core movement inside PCGV under different opening and closing times of pilot valve. The result shows that, shorter opening and closing time of valve

Ultrasonic Additive Manufacturing (UAM), or Ultrasonic Consolidation as it is also referred, is a hybrid form of manufacture, primarily for metal components. The unique nature of the process permits extremely novel functionality to be realised such as multi-material structures with embedded componentry. UAM has been subject to research and investigation at Loughborough University since 2001. This

Ultrasonic Additive Manufacturing (UAM) has been subject to research and investigation at Loughborough University since 2001. In recent years, three particular areas of significant focus have been: The influence of pre-process material texture on interlaminar bonding. Secure fibre positioning through laser machined channels. Freeform electrical circuitry integration. This paper details the key fin

Periodiska systemet växer - existensen av nya supertunga grundämnen rapporteras och verifieras fortlöpande allteftersom acceleratortekniken och analysmetoderna blir alltmer kraftfulla. Vi talar om enstaka atomer av mycket kortlivade isotoper, framställda genom kärnreaktioner. Deras kemi är av naturliga skäl outforskad.Verifiering och namngivning av dessa grundämnen är en komplicerad procedur.

Myelin-sensitive quantitative (q) MRI techniques including MT (3D FLASH) and DTI (single-shot STEAM) are of growing importance to study white matter (WM) disorders in childhood. Cerebral folate transport deficiency is an inherited, treatable WM disorder with hypomyelination, developmental regression, movement disturbances, and epilepsy. One patient with this diagnosis and severe phenotype was trea

We have developed a combinatory antibody-antigen microarray for direct screening of multiple single-chain fragment variable (scFv) clones with no need for pre-purification or enrichment before screening. The straightforward workflow allows for early selection of binders to predefined peptide and glycopeptide targets. A capture antibody is contact printed on microarray slides, side by side with the

Understanding complex social-ecological systems, and anticipating how they may respond to rapid change, requires an approach that incorporates environmental, social, economic, and policy factors, usually in a context of fragmented data availability. We employed fuzzy cognitive mapping (FCM) to integrate these factors in the assessment of future wildfire risk in the Chiquitania region, Bolivia. In

This document demonstrates a conceptual study, design and development of unconventional electromagnetic actuators for applications where a high torque over a limited part of a rotational turn is required. The unconventionality of the actuators is that the electromagnetic actuation is applied directly on a high ratio transmission gear such as a cycloid disc in a cycloid drive or a flex-spline in a

In this paper, we describe a new system to extract, index, search, and visualize entities on Wikipedia. To carry out the extraction, we designed a high-performance entity linker and we used a document model to store the resulting linguistic annotations. The entity linker ,HERD, extracts the mentions from text using a string matching Engine and links the mto entities with a combination of rules, Pa

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti

Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet tran