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Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion.

Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca(2+)-induced exocytosis in pancreatic beta-cells, an effect suggested to involve the cytosolic redox protein glutaredoxin-1 (GRX-1). We here detail the role of GRX-1 in NADPH-stimulated beta-cell exocytosis and glucose-stimulated insulin secretion. Silencing of GRX-1 by RNA interference reduced glucose-stimulated insulin secretion in b

Injury markers predict time to dementia in subjects with MCI and amyloid pathology.

OBJECTIVES: Alzheimer disease (AD) can now be diagnosed in subjects with mild cognitive impairment (MCI) using biomarkers. However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology. METHODS: We pooled subjects from the VU Un

A meta-analytical approach to qualitative studies in music education: a new model applied to creativity and composition

Qualitative methods are well established in music education research. This has led to an interesting body of research, each project investigating in depth a specific situation or phenomenon. One way of combining the advantages of qualitative studies with the aim of acquiring general theories Of music education might be to develop methods of re-analyzing primary studies on a secondary, meta level.

Local Polynomial Regression with Application on Lidar Measurements

This thesis deals with the problem of estimating a function or one of its derivatives from a set of measurements, mainly of a bivariate or spatial nature which is so common in environmental applications. In this work particular attention has been on the lidar (light detection and ranging) application which is a versatile technique for measurement of among other things atmospheric trace gases. In l

Development and evaluation of a lightweight root cause analysis method (ARCA method) - field studies at four software companies

Abstract in UndeterminedContextThe key for effective problem prevention is detecting the causes of a problem that has occurred. Root cause analysis (RCA) is a structured investigation of the problem to identify which underlying causes need to be fixed. The RCA method consists of three steps: target problem detection, root cause detection, and corrective action innovation. Its results can help with

Minimetern hjälper hjärnskadade att kommunicera

Specialutvecklad elektronik för rehabilitering avhjärnskadade är tidsödande och dyrbar att utveckla. Björn Breidegard från Certec, Lunds tekniska högskola, berättar här hur man i stället kan använda enbillig TV-kamera i kombination med dator och programvara. Resultaten är mycket lyckade.

Empirical studies of financial asset returns

This dissertation aims at understanding differences in rates of returns on financial assets, both in the cross-section and over time. It contains four chapters. The first paper is "Non-separable preferences and risk aversion: Results from the UK". Due to poor empirical support of the Consumption Capital Asset Pricing Model it has been suggested that the model should be specified as being non-separ