Investigating the role of DnaJ proteins in the suppression of tau aggregation
Tauopathies belong to a group of neurodegenerative diseases that are characterized by the presence of neurofibrillary tangles in neurons and includes diseases such as Alzheimer´s disease and frontotemporal dementia. Neurofibrillary tangles are insoluble deposits that are composed mainly of tau, which normally acts to stabilize microtubules. In disease, tau forms fibrillar and oligomeric species, wHelpers of helpers – co-chaperone proteins and protein aggregation Proteins are one of the essential molecules that make up our bodies and the bodies of all living beings. Chaperone proteins exist as a protein ¨helper,¨ folding, maintaining, and regulating other proteins. To help these helpers, co-chaperone proteins, ¨helpers of helpers,¨ regulate chaperone proteins and help them by carrying out
