Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We

This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data pro

Almost all eye-movement researchers use algorithms to parse raw data and detect distinct types of eye movement events, such as fixations, saccades, and pursuit, and then base their results on these. Surprisingly, these algorithms are rarely evaluated. We evaluated the classifications of ten eye-movement event detection algorithms, on data from an SMI HiSpeed 1250 system, and compared them to manua

Sammanfattning av eget föredrag om tidningen Lundagårds symboldjur "Quatten" (hållet för Sällskapet Pelle Svanslös Vänner i Uppsala 2015-11-16)

This study describes an alpha-lactalbumin folding variant from human milk with bactericidal activity against antibiotic-resistant and -susceptible strains of Streptococcus pneumoniae. The active complex precipitated with the casein fraction at pH 4.6 and was purified from casein by a combination of anion exchange and gel chromatography. Unlike other casein components, the active complex was retain

CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). Earlier studies suggested that extracellular Mg(2+) signalled through the presumed sensor histidine kinase, CsrS. We now confirm those findings, as complementation of a csrS mutant restored Mg(2+)-dependent gene regulation. Moreover,

This study analyzed the effect of breast-feeding on the frequency of acute otitis media. The protocol was designed to examine each child at 2, 6 and 10 months of age. At each visit nasopharyngeal cultures were obtained, the feeding pattern was recorded and the acute otitis media (AOM) episodes were documented. The analysis was based on 400 children from whom complete information was obtained. They

The purpose of this study was to investigate the effects of a Buddhist meditation intervention on empathy, perceived stress, mindfulness, self-compassion, and of particular interest, the dispositional tendency to feel empathic concern rather than personal distress when perceiving another as in need, termed altruistic orientation. Participants were randomly assigned to an intervention group (n = 20

TEKNOsim is a well-established software tool for simulation of thermal indoor climate. It is used for modelling and simulation of thermal loads, indoor temperatures and thermal comfort. TEKNOsim 5, a new version of the simulation tool has been launched with several new features and enhanced functionalities. This paper presents results of testing and validation of TEKNOsim 5 against two state-of-th

The Thesis is based on 6 original articles

BACKGROUND: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images.GOALS: Multicenter retrospective study aiming to invest

The most used pavement for paved roads in the world is asphalt. It is therefore important that the asphalt is as durable as possible to avoid expensive repairs of the roads. One important factor of the durability of the road is the adherence between the stones and the bitumen that holds the stones together. The affinity is tested by the so called rolling bottle test, where one put stones covered i

Mitigating climate change will affect energy systems and have consequences that reach beyond environmental policies. The studies presented in this thesis analyse how reducing emissions of greenhouse gases affect (energy) security. The focus is on strategies which improve energy efficiency or increase the share of renewable energy.This thesis is based on five papers in which frameworks for conceptuMitigating climate change will affect energy systems and have consequences that reach beyond environmental policies. The studies presented in this thesis analyse how reducing emissions of greenhouse gases affect (energy) security. The focus is on strategies which improve energy efficiency or increase the share of renewable energy.This thesis is based on five papers in which frameworks for conceptu

BACKGROUND: Twin studies have been criticized for upwardly biased estimates that might contribute to the missing heritability problem.METHOD: We identified, from the general Swedish population born 1960-1990, informative sibships containing a proband, one reared-together full- or half-sibling and a full-, step- or half-sibling with varying degrees of childhood cohabitation with the proband. Estima

The temperature and density profiles of protoplanetary discs depend crucially on the mass fraction of micrometre-sized dust grains and on their chemical composition. A larger abundance of micrometre-sized grains leads to an overall heating of the disc, so that the water ice line moves further away from the star. An increase in the water fraction inside the disc, maintaining a fixed dust abundance,

Several severe fires in structural elements, or so-called "structural fires", have occurred in Sweden in recent years. In order to study this phenomenon, a dozen fires in structural elements have been studied in a recent project. This paper provides a description of the characteristics of "structural fires" and examples of how such events can be managed and limited. Constructional fire protection,

In general, diffusion rates in extractions are enhanced by increasing the temperature. In this study, we instead add compressed liquid carbon dioxide to the extraction phase to accomplish faster mass transfer. The feasibility of using carbon dioxide expanded ethanol (CXE) as the extraction phase was explored, targeting two medium-polar analytes, α-pinene and cis-verbenol in Boswellia sacra tree re

Platelets have been reported to become activated in response to bacteria and this is proposed to contribute to the acute response to bacterial infection. In the present study, we investigated platelet aggregation in response to group G streptococci (GGS) in vitro in healthy human donors and in vivo in a mouse model of streptococcal sepsis. Platelet aggregation by GGS was dependent on the bacterial