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In vivo measurement of pre-operational spallation source workers : Baseline body burden levels and detection limits of relevant gamma emitters using high-resolution gamma spectrometry

As a measure to prepare for long-term internal dose monitoring of workers at the European Spallation Source (ESS) in Lund, Sweden, operated by the European Research Infrastructure Consortium (ERIC), as well as to enhance emergency preparedness against accidental releases, a series of in vivo measurements were conducted using a high-resolution HPGe detector with a 123% relative efficiency (1.332 Me

Male unaccompanied refugee minors’ perceptions of relationships and information about sexual health in Sweden - ‘it feels like you’ve been in prison and then set free’

Unaccompanied refugee minors represent a potentially vulnerable group regarding sexual and reproductive health and rights, particularly due to the circumstances surrounding their migration. Research is scarce about the sexual and reproductive health and rights needs of unaccompanied minors, many of whom come from countries with limited access to information about sexual and reproductive health and

Towards unconstrained compartment modeling in white matter using diffusion-relaxation MRI with tensor-valued diffusion encoding

Purpose: To optimize diffusion-relaxation MRI with tensor-valued diffusion encoding for precise estimation of compartment-specific fractions, diffusivities, and T2 values within a two-compartment model of white matter, and to explore the approach in vivo. Methods: Sampling protocols featuring different b-values (b), b-tensor shapes (bΔ), and echo times (TE) were optimized using Cramér-Rao lower bo

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is

Knockout of the radical scavenger α1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight

α1-microglobulin (A1M) is a ubiquitous protein with reductase and radical- and heme-binding properties. The protein is mainly expressed in the liver and encoded by the α1-microglobulin-bikunin precursor (AMBP) gene together with the plasma proteinase inhibitor bikunin. The AMBP polypeptide is translated, glycosylated and the C-terminal bikunin part linked via a chondroitin sulfate glycosaminoglyca

Live GUI development for service-based systems

In an increasingly connected world where all manner of devices can communicate over the Internet, conventional methods for developing GUIs (Graphical User Interfaces) are insufficient. For systems of such devices, it must be possible to develop the system itself independently from its GUI(s). In this paper, we present an approach for developing GUIs towards already deployed, or "live", service-bas

Rättigheter och rättvisa

Kampen för social rättvisa tar sig många former, alltifrån att ta saken till domstolen till protester på gatorna. I detta kapitel introducerar jag Luc Boltanskis och Laurent Thévenots teori om rättfärdigande och diskuterar hur den kan användas för att analysera sociala aktörers krav på rättigheter och rättvisa i rättssociologisk forskning. I slutet av kapitlet ger jag två exempel från min forsknin

Immunological aspects of intratumoral chemotherapy and immunotherapy in malignant brain tumors

Hjärntumörer utgör omkring 2 procent av alla cancerdiagnoser och den vanligaste elakartade hjärntumörtypen är glioblastom (GBM). Patienter med GBM behandlas i dag med kirurgi, cellgifter och strålbehandling, men sjukdomen går sällan att bota och det krävs nya och mer effektiva behandlingsstrategier.I min doktorsavhandling har jag använt tre olika musmodeller, kallade GL261, KR158 och SB28, för attAdvances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. Immunothera

Independent Control of Nucleation and Layer Growth in Nanowires

Control of the crystallization process is central to developing nanomaterials with atomic precision to meet the demands of electronic and quantum technology applications. Semiconductor nanowires grown by the vapor-liquid-solid process are a promising material system in which the ability to form components with structure and composition not achievable in bulk is well-established. Here, we use in si