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The conversion of vanillin to vanillylamine is a key step in the biosynthetic route towards capsaicinoids in pungent cultivars of Capsicum sp. The reaction has previously been annotated to be catalysed by PAMT (putative aminotransferase; [GenBank: AAC78480.1, Swiss-Prot: O82521]), however, the enzyme has previously not been biochemically characterised in vitro.

Holmqvist ME, Wedren S, Jacobsson LTH, Klareskog L, Nyberg F, Rantapaa-Dahlqvist S, Alfredsson L, Askling J (Institute of Environmental Medicine, Karolinska Institutet, Stockholm; Karolinska Institutet/Karolinska Hospital, Stockholm; Malmo University Hospital, Malmo; AstraZeneca R&D, Molndal; and Umea University Hospital, Umea, Sweden) Rapid increase in myocardial infarction risk following dia

Microscopic and crystallographic studies shed light on key steps in the protein synthesis process in ribosomes.

Cigarette smoking is a major risk factor for cardiovascular and respiratory diseases. Contractile receptor changes have been observed in several vascular diseases. The intracellular mitogen activated protein kinase (MAPK) signaling pathways are suggested to be associated with receptor upregulation. The present study therefore aimed to investigate the status of vascular and bronchial receptor chang

Waste incineration bottom ash fine fraction contains a significant amount of aluminium, but previous works have shown that current recovery options based on standard on-step Eddy Current Separation (ECS) have limited efficiency. In this paper, we evaluated the improvement in the efficiency of ECS by using an additional step of crushing and sieving. The efficiency of metallic Al recovery was quanti

Osteoarthritis of the metacarpo/metatarsophalangeal joints is one of the major causes of poor performance in horses. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) may be a useful technique for noninvasively quantifying articular cartilage damage in horses. The purpose of this study was to describe dGEMRIC characteristics of the distal metacarpus3/metatarsus3 (Mc3/Mt

Force sensing provides robots the capability to accomplish tasks where physical interaction with the environment is required, such as assembly. Small position uncertainties can then be corrected for by sensing the contact forces. This thesis considers the problem of force-controlled assembly, including how tasks can be specified in a simple and intuitive way and how robust task execution under unc

This paper presents a new method, based on constraint programming, for modeling and solving scheduling and instruction selection for processors extended with a functionally reconfigurable cell fabric. Our method models parallel reconfigurable architectures, the selection of application specific computational patterns and application scheduling. It takes also into account architectural constraints.

Fourier transform infrared spectroscopy (FTIRS) can provide detailed information on organic and minerogenic constituents of sediment records. Based on a large number of sediment samples of varying age (0-340 000 yrs) and from very diverse lake settings in Antarctica, Argentina, Canada, Macedonia/Albania, Siberia, and Sweden, we have developed universally applicable calibration models for the quant

Background: Overweight is reported as a side effect of SDR. The aims were to study the development of weight, height and body mass index (BMI) during five years after SDR. Methods: This prospective, longitudinal and practice-based study included all 56 children with CP spastic diplegia undergoing SDR from the start in March 1993 to April 2003 in our hospital. The preoperative Gross Motor Function

BACKGROUND:To estimate and compare prevalence of overweight and obesity among adult people across the 22 districts of Tehran in 2011. METHODS:This was a cross-sectional study using data on 47,406 women and 47,525 men aged≥ 15 years from a large population-based survey (Urban HEART-2). Age-standardized prevalence (ASP) of overweight (25≤BMI<30) and obesity (BMI≥30) were estimated for the Tehran's d

As discussed in the previous issues of QMJIP, the Federal Circuit's decisions in Myriad I-2 and II3 appear to provide considerable prospects for patentees, as clever claim drafting may still help to avoid most patent-eligibility traps set by the much debated US Supreme Court decision in Prometheus.(4) Yet, the split opinions also contain elusive reasoning by each of the three judges. The questions

The title compound, {(C14H16P)[Cu5I6]} (n) , prepared from the reaction between copper powder, iodine and dimethyldiphenylphosphonium iodide in hydroxyacetone, features an anion that consists of a continuous two-dimensional Cu-I sheet [Cu-I = 2.5960 (14)-2.6994 (13) A and Cu-I-Cu = 63.28 (5)-114.25 (5)degrees]. The cation, which lies on a mirror plane, is a typical dimethyldiphenylphosphonium ion.

Aim: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. Methods: Case studies. Results: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up,

Artikeln undersöker hur berättelser om människor och apor, från scala natuae, via evolutionsberättelsen till moderna romaner förhållit sig till konstruktionen av tid och temporalitet - hur exempelvis bilden av tävling mellan människa och apa - där människan tar sig upp och fram, medan apan hamnar på efterkälken, bidragit till idén om progressiv, kronologisk tid, medan andra mer hybridiska berättel

Varje år genomgår mer än en tredje del av alla 15-åringar konfirmandundervisning. Ungdomarna uppskattar konfirmationen - inte minst att planera och genomföra gudstjänster. Men vanliga gudstjänster har de inte så mycket till övers för.

Background: Most composite indices of disease activity and response criteria in RA have been validated and compared in clinical trials rather than routine care. We therefore wanted to compare the performance of the DAS28, SDAI and CDAI activity indices, their activity states, their response criteria, and also compare with the ACR response criteria in an observational clinical setting. Methods: Agr

DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during differentiation of self-renewing stem cells. However, whether these changes are the cause or consequence of stem cell fate remains unknown. Here, we show that alternative functional programs of hematopoietic stem cells (HSCs) are governed by gradual differences in methylation levels. Constitutive methylation is es