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Background & Aims The risk of hepatocellular carcinoma (HCC) in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with over 3.000 PSC-subjects. Approach & results Subjects with well characterized PSC (n=3.071) were fo

Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limited. This study aimed to determine whether blood-based biomarkers in amyloid-positive individuals with SCD (A + SCD) support the notion of stage 2 as a distinct st

The relationship between requirements engineering and testing has been a key interest throughout my research career. It cannot be that requirements engineers are from Omicron Persei 7 and testers from Omicron Persei 9—we all live on the same planet. I’m happy to co-author this column with a former collaborator from a test automation EU project, now a manager at Ericsson. With this issue’s focus on

This column summarizes a panel discussion given by REFSQ 202 held in Barcelona on responsibility. Given the mediator role of our field, what other soft- ware engineering discipline could be a better fit for responsible engineering? And this will just keep getting more important as the influence of technology on society increases.

Could maintainability requirements help organizations prioritize technical debt management? The new standard ISO/IEC 5055 Automated Source Code Quality Measures can be used to set targets. We also look at a pragmatic way to turn CodeScene’s code health metric into a quality gate for pull requests.

As a general-purpose technology, large language models promise to enhance various software engineering tasks. But how will they impact requirements engineering? This column offers a summary of an expert panel discussion from the 2023 International Requirements Engineering Conference in Hanover, Germany.

Objective: Quality measures in healthcare are crucial for improving outcomes and ensuring patient safety. This study investigated the evolution, implementation, and impact of Primary Care Quality (PCQ). The PCQ aims to facilitate nationwide quality benchmarking, serving as a tool for quality improvement (QI) and research. Design/Settings: A descriptive design outlining the development and operatio

Introduction: Chemoradiotherapy is standard treatment for limited-stage SCLC. However, most patients relapse and there is a need for better treatment. We investigated whether twice-daily thoracic radiotherapy (TRT) of 60 Gy/40 fractions improves survival compared with the established schedule of 45 Gy/30 fractions. Here, we report final survival data and long-term toxicity. Methods: Randomized, op

This column celebrates 40 years of IEEE Software through a retrospective on Requirements Engineering. Two seasoned experts discuss the discipline’s evolution from structured methodologies to AI-driven approaches. Finally, we speculate on future trends.

This column presents the evolution of sentiment analysis from a requirements engineering perspective. With large language models, the technology is now accessible to all. From novices to expert users, we discuss suitable ways to get started.

Objectives: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the detection and handling of HIL-samples used by laboratories in Europe in the context of coagulation testing. Methods: A Surv

Background and aims: The relationship between uncommon phenotypes, such as metabolically healthy obesity and normal weight with metabolic syndrome (MetS), and cardiovascular disease (CVD) risk, remains unclear. We investigated how different combinations of body mass index (BMI) and MetS are associated with overall and specific CVDs and how the number of MetS components influences CVD risk in indiv

Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities

Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura

In this work, we revisit unweighted event generation for multi-parton tree-level processes in massless QCD. We introduce a two-step approach, in which initially unweighted events are generated at leading-colour (LC) accuracy, followed by a reweighting of these events to full-colour (FC) accuracy and applying an additional unweighting cycle. This method leverages the simple structure of LC integran

BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy

Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor