Objective: To assess mortality in patients with rheumatoid arthritis ( RA) treated with tumour necrosis factor (TNF) inhibitors, compared with a standard RA population. Methods: Patients were recruited from a regional register, which includes over 90% of patients with RA treated with TNF blockers in the area in 1999 or later, and a local community-based cohort of patients with RA, established in 1

Electrostatic interactions in proteins can be probed experimentally through determination of residue-specific acidity constants, We describe here triple-resonance NMR techniques for direct determination of lysine and arginine side-chain protonation states in proteins. The experiments are based on detection of nonexchangeable protons over the full range of pH and temperature and therefore are well

Popular Abstract in Swedish Denna avhandling hade som målsättning att belysa långtidsförloppet vid primärt Sjögrens syndrom (SS). Studierna är baserade på registret över SS-patienter vid Universitetssjukhuset MAS och de Amerikansk-Europeiska konsensuskriterierna för SS från 2002. Helicobacter pylori (H. pylori) är inte mer prevalent bland SS-patienter än bland kontrollpersoner. Bakteriens förekomThis work was aimed at improving our understanding of the course of primary Sjögren's syndrome (SS). The Malmö SS patient register and the 2002 American-European Consensus Criteria formed the basis of all studies. Helicobacter pylori (H. pylori) was not more prevalent in SS patients or associated with severe glandular or immunological dysfunction. Consequently, our results do not support screenin

The Rare ISotopes INvestigation at GSI project combines the former EUROBALL Ge-Cluster detectors, the MINIBALL Ge detectors, BaF2--HECTOR detectors, and the fragment separator at GSI for high-resolution in-beam gamma-ray spectroscopy measurements with radioactive beams. These secondary beams produced at relativistic energies are used for Coulomb excitation or secondary fragmentation experiments in

Popular Abstract in Swedish Denna avhandling handlar om hur personer, som insjuknat i stroke, beskriver sina upplevelser och erfarenheter av att leva med stroke och hur de lär sig hantera sin livssituation. Kunskaper om läroprocesser i en livsomställning, som insjuknande i stroke innebär, är betydelsefulla för att kunna förstå, möta och stödja människor i sådana situationer. Under de senaste årtioThis thesis concerns how people with stroke describe their experiences of life with stroke and how they learn to live with stroke. In the western world the interest for research in lived experiences has increased. This might be due to the higher rate of people with illness and lifelong diseases. The aim of the study is to analyze stories from persons with stroke of their lived experiences of life

We examined the relationship between plasma levels of corticosterone and the migratory activity and directional preference of red-eyed vireos during fall migration at the northern coast of the Gulf of Mexico. Corticosterone is thought to play a role in physiological and behavioural processes before, during, and after long-distance migratory flights. An increase in corticosterone at the onset of mi

We investigate under which conditions we can expect the evolution of costly male care for unrelated offspring, when the benefit of such care is in the form of increased mating success. This applies to male helping behavior that cannot be explained as paternal care because the male's own offspring does not benefit from his behavior. Our model shows that caring for others' offspring can be a stable

High-resolution laser fluorescence spectroscopy, using a single-mode dye laser acting on a collimated atomic beam, has been performed to determine the hyperfine-structure (hfs) constants in six states of the 6p 5d configuration of135Ba and137Ba. Isotope shifts (IS) for eleven transitions between the 6s 5d and the 6p 5d configurations have also been measured. From an analysis of the energy levels,

Reacting [PtCl(PTA)(3)]Cl (PTA = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1(3,7)]decane) with KSeCN in aqueous or MeOH medium results in the abstraction of the PTA ligands to yield Se = PTA. The reaction also proceeds quantitatively by direct reaction of PTA and KSeCN in water or methanol. The methylated PTA ligand, [PTA-Me]I (1-methyl-1-azonia-3,5-diaza-7-phosphatricyclo[3.3. 1.1(3,7)]decane iodide),

Aim This paper presents a probabilistic method for the characterization of pollen taxa using attributes, and for the reconstitution of past biomes. The probabilities are calculated on the basis of European floristic and pollen databases sufficiently large and exhaustive to provide robust estimates. Location The analysis is based on data from approximately 1000 sites throughout Europe. Method We us

To determine the variability in fibre areas in the human vastus lateralis muscle, cross-sections (15 microns) of whole autopsied muscles from eight young men have been prepared, and the cross-sectional area (CSA) of 375 type 1 and 375 type 2 fibres has been measured in five different regions throughout each muscle. The CSA of both fibre types varied significantly within all muscle cross-sections.

Introduction: A large number of air traffic control occurrences take place without resulting in loss of separation between aircraft. Unfortunately such occurrences are seldom reported and therefore not used for disclosing system weaknesses, Such as inappropriate methods and procedures. The ATCC (Air Traffic Control Centre) Malmoe made a trial with local reporting of "learning occurrences". The tri

BACKGROUND: Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation. Receptors recognising various microbes have been identified, but the signalling pathways are not entirely understood. Cytosolic phospholipase A2 is a major down-stream target and this enzyme is regulated by both phosphorylation

This paper presents a first study of the pseudoscalar meson masses to two loops, or next-to-next-to-leading order, within the supersymmetric formulation of partially quenched chiral perturbation theory (PQchiPT). The expression for the pseudoscalar meson mass in the case of three valence and three sea quarks with equal masses, but different from each other, is given to O(p(6)), along with a numeri

A group of normal subjects (n = 17) was compared with two groups of patients, either with vestibular neuritis (n = 18) or with acoustic neuroma (n = 35) by means of posturography when stance was perturbed with vibrators attached to the calf muscles. Dynamic control of human posture was quantified by means of system identification, and the characteristic parameters of swiftness, stiffness, and damp

Mechanical interlock obtained by penetration of bone cement into cancellous bone is critical to the success of cemented total hip replacement (THR). Although acetabular component loosening is an important mode of THR failure, the properties of acetabular cancellous bone relevant to cement penetration are not well characterized. Bone biopsies (9 mm diameter, 10 mm long) were taken from the articula