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Detecting the vulnerable plaque in patients.

Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture-prone atherosclerotic plaques have a distinct morphology, namely a thin, inflamed fibrous cap covering a large lipidic and necrotic core. With the fast development of imaging techniques in the last decades, detecting vulnerable plaques thereby ide

Tax policy and entrepreneurship: Empirical evidence from Sweden

This paper examines the relationship between income taxes and the decision to become self-employed using data from Sweden. By making it possible to track a large number of individuals over extended time periods and across a number of tax rate changes while controlling for important additional determinants, available tax-return information from Sweden allows for statistical estimation of the influe

Numerical simulations of absorption properties of InP nanowires for solar cell applications

In this paper, we present results of optical simulations on the absorption of nanowires. The simulation was performed with rigorous coupled wave analysis to determine the potential of nanowires for use in a new kind of nanostructured solar cell. The overall absorption of the solar cell structure was calculated for four different diameters of the nanowires and also in dependence of light wavelength

Site-specific survival rates for cancer of unknown primary (CUP) according to location of metastases.

Cancer of unknown primary (CUP) is diagnosed at the metastatic stage and despite extensive diagnostic work-up the primary tumor often remains unidentified. Limited population-based survival data are available for metastatic location and none are available that link the location with the cause of death, which might give clues about the tissue of origin. A total of 9,306 CUP patients with extranodal

Occupational and socio-economic risk factors for giant cell arteritis: a nationwide study based on hospitalizations in Sweden.

Objectives: Socio-economic and occupational factors may contribute to risk of immune-mediated disorders. The importance of these factors in giant cell arteritis (GCA) is unknown. This is the first nationwide study with the aim of investigating possible associations between socio-economic status (SES)/occupation and hospitalization for GCA. Method: A nationwide database was constructed by linking S

Novel Mutation in the KCNJ2 Gene Is Associated with a Malignant Arrhythmic Phenotype of Andersen-Tawil Syndrome.

Andersen-Tawil syndrome (ATS) is a rare inherited multisystem disorder associated with mutations in KCNJ2 and low prevalence of life-threatening ventricular arrhythmias. Our aim was to describe the clinical course of ATS in a family, in which the proband survived aborted cardiac arrest (ACA) and genetic screening revealed a previously unknown mutation (c.271_282del12[p.Ala91_Leu94del]) in the KCNJ

Measurement of breast volume is a useful supplement to select candidates for surgical breast reduction

INTRODUCTION: The indication for breast reduction in a public welfare or an insurance paid setting depends on the severity of the subjective symptoms and the clinical evaluation. The purpose of this study was to evaluate the use of breast volume as an objective criterion to establish the indication for breast reduction surgery, thus establishing a standard decision basis that can be shared by surg

Multiplexing Chopper Systems for Pulsed Neutron Sources: Practical Basics

Multiplexing techniques can be used for enhancing neutron scattering experimental capabilities at pulsed neutron sources. They consist of chopper systems which extract several neutron pulses with different wavelength distributions from each source pulse. In recent years such methods have been experimentally well established for both elastic and inelastic neutron scattering. The current paper revie

Application of Polygonal Finite Elements to Two-Dimensional Mechanical and Electro-Mechanically Coupled Problems

Naturally evolving Voronoi discretisation of two-dimensional plane domains renders representative microstructures that turn out to be useful for the modelling and simulation of polycrystalline materials. Hybrid finite element approaches are employed on such polygonal discretisations to solve, for instance, mechanical and electromechanical problems within a finite element context. In view of solvin

External Validation of Diagnostic Models to Estimate the Risk of Malignancy in Adnexal Masses

Purpose: To externally validate and compare the performance of previously published diagnostic models developed to predict malignancy in adnexal masses. Experimental Design: We externally validated the diagnostic performance of 11 models developed by the International Ovarian Tumor Analysis (IOTA) group and 12 other (non-IOTA) models on 997 prospectively collected patients. The non-IOTA models inc

Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence.

Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as first described for Streptococcus pyogenes and the antiphagocytic M6 protein. It is commonly assumed that FH recruited to an M protein enhances virulence by protecting the bacteria against complement deposition and phagocytosis, but the role of FH-binding in S. pyogenes pathogenesis has remained un

Nigral 6-hydroxydopamine lesion impairs performance in a lateralised choice reaction time task-Impact of training and task parameters

Unilateral intrastriatal and intra-medial forebrain bundle injections of 6-OHDA impair the performance in a lateralised choice reaction time task. However, the extent and pattern of deficits after nigral 6-OHDA injections is less well studied, as well as the impact of training regime or the modification of various task parameters. The nigral 6-OHDA lesion resulted in impaired response accuracy and

Greening in the circumpolar high-latitude may amplify warming in the growing season

We present a study that suggests greening in the circumpolar high-latitude regions amplifies surface warming in the growing season (May-September) under enhanced greenhouse conditions. The investigation used a series of climate simulations with the Community Atmospheric Model version 3-which incorporates a coupled, dynamic global vegetation model-with and without vegetation feedback, under both pr

Green-Glued Products for Structural Applications

The results from bending tests on 107 laminated, green-glued, beams manufactured from Norway spruce side boards are presented. The beams were made by face gluing 21-25 mm thick boards using a commercial one-component moisture curing polyurethane adhesive. In addition to the bending test results, results from shape stability measurements after climatic cycling and bond line strength and durability

Interleaved parton showers and tuning prospects

General-purpose Monte Carlo event generators have become important tools in particle physics, allowing the simulation of exclusive hadronic final states. In this article we examine the PYTHIA 8 generator, in particular focusing on its parton-shower algorithms. Some relevant new additions to the code are introduced, that should allow for a better description of data. We also implement and compare w

Allelic variation at innate immune genes (avian beta-defensins), within a natural population of great tits

In order to fully understand pathogen induced natural variation in fitness in wild animal populations it is important to identify and study the degree of non-synonymous alleles in genes that code for components of the immune system. This study investigates the degree of natural genetic variation at 6 innate immune genes belonging to the -defensin family within a single population of birds, the gre