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Analysis of giant cell tumour of bone cells for Noonan syndrome/Cherubism-related mutations.

Background: Giant cell tumour of bone (GCTB) is an osteolytic tumour which contains numerous osteoclast-like giant cells and a proliferation of mononuclear stromal cells (MSC). Giant cell-rich osteolytic lesions can also develop in the jaw bones in Noonan syndrome, a cherubism-like developmental abnormality that is transmitted in an autosomal dominant fashion, often because of mutation in the PTP

Rho-Kinase Inhibitor Attenuates Cholestasis-Induced CXC Chemokine Formation, Leukocyte Recruitment, and Hepatocellular Damage in the Liver.

BACKGROUND: In the present experimental study, we analyzed the role of Rho-kinase during obstructive cholestasis by studying the effect of the Rho-kinase inhibitor Y-27632 on hepatic CXC chemokine formation, leukocyte recruitment and hepatocellular damage. MATERIALS AND METHODS: C57BL/6 mice underwent bile duct ligation (BDL) to induce obstructive cholestasis. Mice were pretreated with Y-27632 (1

IS ADAPTED APD THEORETICALLY MORE EFFICIENT THAN CONVENTIONAL APD?

♦ Background: A modified version of automated peritoneal dialysis (APD) using not only variable dwell times but also variable fill volumes has been tested against conventional APD (cAPD) with fixed dwell volumes in a randomized controlled clinical study. The results have indicated that the modified schedule for APD, denoted adapted APD (aAPD), can lead to improved small solute clearances, and, abo

A Home-Proxy Based Wireless Internet Framework in Supporting Mobility and Roaming of Real-Time Services

Due to the lack of support in mobility and quality of service, today's IF-based networks have some inherent limitations: for delivering multimedia services in a mobile environment. In the past few years, these issues have been addressed in the research community and the resulting techniques: are being standardised. However, these development have been done in isolation and become incompatible with

On CFD-Analysis of Heat Transfer of a Heavy-Duty Diesel Engine

In this work, a heavy-duty diesel engine was studied by employing CFD simulations on a closed volume engine segment. These simulations were used to evaluate both the effects from certain parameters on the wall heat transfer, and to examine how reduction of heat transfer would effect the engine performance and emission levels. In the first study, an initial investigation concerning the in- cylinde