Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the pre

Background: Epileptic seizures are associated with an immune response in the brain. However, it is not known whether it can extend to remote areas of the brain, such as the eyes. Hence, we investigated whether epileptic seizures induce inflammation in the retina. Methods: Adult rats underwent electrically induced temporal status epilepticus, and the eyes were studied 6 h, 1, and 7 weeks later with

Scandinavian is known to have vocative phrases that contain a possessive second person pronoun and a noun, and possibly also one or more adjectives, as in the Norwegian example din lille fjott, which means ‘you little dork’ although din is formally identical to the possessive pronoun for second person singular. In this paper, I will show that possessive predicational vocatives, as I call them, inv

Temanummer om Alfred Hitchcock med anledningen av hundrårsdagen av hans födelse. Innehåll: Ledare: Alfred Hitchcock 100 år (Michael Tapper), Filmografi 1922-1976 (Michael Tapper), Hitchcock Revisited (Örjan Roth-Lindberg), Hitchcock på Henley's: Ett porträtt av regissören som ung (Patrick McGilligan), Hitchcock - engelsman (Charles Barr), Hitchcock och modernismen (Daniel Lindvall), Hitchcocks ant

Sphingosine 1-phosphate (S1P) is an important regulator of vascular integrity and immune cell migration, carried in plasma by high-density lipoprotein (HDL)-associated apolipoprotein M (apoM) and by albumin. In sepsis, the protein and lipid composition of HDL changes dramatically. The aim of this study was to evaluate changes in S1P and its carrier protein apoM during sepsis. For this purpose, pla

Aims/hypothesis: Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and Cart−/− mice have diminished insulin secretion. We aimed to test if CART is differentially regulated in human type 2 diabetic islets and if CART affe

Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are transferred to the offspring and exert physiological regulatory functions, and the nutritional hypothesis, which suggests that these molecules do not reach the systemic circulation of the mi

Objective: To highlight expectant parents’ attitudes concerning prenatal diagnosis, what the parents wish to know and what they chose not to know about their unborn baby, also in what form and to what extent they wish for prenatal diagnosis. Background: Parents have to make decisions concerning prenatal diagnosis. Screening programmes change rapidly and there is a need for parental influence on th

Contents: Editorial (Michael Tapper), The Corporation: Interview with the Filmmakers (Eija Niskanen), Claire Denis: Cinema of Transgression 1:2 (Robin Wood), Fueled by Enthusiasm: Interview with V.F. Perkins (Jeffrey Crouse), Taiwanese Triads: Mahjong and Goodbye, South, Goodbye (Gina Marchetti). Reviews: books, dvds, films.

Legal certainty is central to taxation decisions. This article describes the current legal situation and discussions in four Nordic countries. Sweden and Finland are specialized in dealing with taxation cases in administrative courts. In Denmark and Norway, no specialization exists in taxation cases. I maintain in this article that legal certainty would benefit from explicit signals from the state

Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B

Climate change is an important new challenge for local authorities. This study analyses the potential for using the Swedish mandatory process for risk and vulnerability analysis (RVA) as a vehicle to improve local climate adaptation work. An advantage with RVA is its comprehensive approach in dealing with all relevant threats and all vital functions of society. In order to test the applicability o

Objective Overproduction of cell-free fetal hemoglobin (HbF) in the preeclamptic placenta has been recently implicated as a new etiological factor of preeclampsia. In this study, maternal serum levels of HbF and the endogenous hemoglobin/heme scavenging systems were evaluated as predictive biomarkers for preeclampsia in combination with uterine artery Doppler ultrasound. Study design Case-control

We investigated the relationship between the affective component (A: the level of offensiveness/intensity) and the behavioral component (B: the frequency of usage) of taboo words that are part of an individual’s natural language (C: the cognitive component). In Study 1, 900 US-residents generated the 10 most common taboo words they use in their daily lives (C). In Study 2, 1000 US-residents were pWe investigated the relationship between the affective component (A: the level of offensiveness/intensity) and the behavioral component (B: the frequency of usage) of taboo words that are part of an individual’s natural language (C: the cognitive component). In Study 1, 900 U.S. residents generated the 10 most common taboo words they use in their daily lives (C). In Study 2, 1,000 U.S. residents w