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We report the development of a high-level bacterial expression system for the Alzheimer's disease-associated amyloid beta-peptide (A beta), together with a scaleable and inexpensive purification procedure. A beta(1-40) and A beta(1-42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-A beta(1-40) and Met-A beta(1-42), referred t

This paper describes how focus group interviews were used in a project on developing research support services. The object of the interviews was to understand the everyday lives of researchers and the obstacles they experience in their research process. Advantages and challenges of the method are discussed, e.g. the benefits of the interaction and the free form that the method allows for and the c

The aim of this pilot study was to assess the association between perceived environmental barriers and perceived participation in everyday life situations encountered by people with late effects of polio. A sample of 45 persons with clinically verified late effects of polio answered the Swedish versions of the Impact on Participation and Autonomy Questionnaire (IPA-S) and the Craig Hospital Invent

In this conceptual paper, we introduce a meso-level theoretical framework (Consumption Field Refinement) to explain the development of market systems and suggest methods for researching this development. Our framework centres on the idea that the market system consists of interlinked subsystems (consumption fields), each focused on a particular consumption activity.

Background:The digestion of sphingolipids (SL) is slow and is catalyzed by mucosal enzymes. Dietary SL was shown to inhibit cholesterol absorption and to lower plasma cholesterol, triglycerides (TG) and hepatic fat accumulation in animal models.Aim:A dairy formulation based on fractionation of buttermilk, which is enriched in milk polar lipids of which SL account for a large part is now available.

This paper explores the interaction between brand orientation and market orientation. Brand orientation is an inside-out, identity-driven approach that sees brands as a hub for an organization and its strategy. Similarly, market orientation is an outside-in, image-driven approach. Initially, brand orientation and market orientation appear to be two different strategic options. Though synergistic c

Electrode grounding resistance is a major factor affecting measurement quality in electric resistivity tomography (ERT) measurements for cryospheric applications. Still, little information is available on grounding resistances in the geophysical literature, mainly because it is difficult to measure. The focus-one protocol is a new method for estimating single electrode grounding resistances by mea

Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. The most important genetic susceptibility towards type 1 diabetes is found within the HLA-region on chromosome 6. We sho

For dynamical systems defined by a covering map of a compact Hausdorff space and the corresponding transfer operator, the associated crossed product C (*)-algebras C(X)a < S (alpha,a"')a"center dot introduced by Exel and Vershik are considered. An important property for homeomorphism dynamical systems is topological freeness. It can be extended in a natural way to in general non-invertible dynamic

Background: A number of the deeper divergences in the placental mammal tree are still inconclusively resolved despite extensive phylogenomic analyses. A recent analysis of 200 kbp of protein coding sequences yielded only limited support for the relationships among Laurasiatheria (cow, dog, bat and shrew), probably because the divergences occurred only within a few million years from each other. It

Mid-Cambrian biotas of the Spence, Wheeler, Marjum, and Weeks formations in Utah are exceptionally diverse. Continued collecting has produced additional trilobites here assigned to one new genus, Meniscopsia, and 25 new species. The new species, all known from complete or nearly complete dorsal exoskeletons, are Amecephalus jamisoni, Athabaskia gladei, Bolaspidella jarrardi, Bolaspidella reesae, B

Popular Abstract in Swedish El-avfall (avfall från elektriska och elektroniska produkter) har under det senaste årtiondet blivit ett växande miljöproblem också i de mindre rika länderna (icke-OECD länder). Informell återvinning i u-länder har lett till att giftiga ämnen, som t.ex. bly och kvicksilver från tv-apparater, PVC från sladdar och bromerade flamskyddsmedel från plastkomponenter, har läcktWaste electrical and electronic equipment (WEEE) has become a salient issue in non-OECD countries. With a growing awareness about serious damages to the environment and human health from a lack of safe treatment and recycling of WEEE, there has been a search for policy responses in several of these countries. This research finds that extended producer responsibility (EPR), a policy principle that

In addition to having constitutive defence traits, many organisms also respond to predation by phenotypic plasticity. In order for plasticity to be adaptive, induced defences should incur a benefit to the organism in, for example, decreased risk of predation. However, the production of defence traits may include costs in fitness components such as growth, time to reproduction, or fecundity. To tes

The Swedish salmonella control programme has been very successful in reducing the number of salmonella infections in both humans and animals. However, the costs for the control have increased and it has thus been questioned if the control measures could be relaxed and, if so, what effect this would have on human and animal health. The aim of the present study is to evaluate the expected effects on

Popular Abstract in Swedish Hållbar utveckling ställer krav på nya riskanalysmetoder Hållbar utveckling bygger på vår förmåga att fatta beslut i dag som avgör vår morgondag. Det låter enkelt, men är en av mänsklighetens största utmaningar då mycket i vår värld hänger samman och framtiden är full av osäkerheter. Givet att osäkerhet tillåts påverka vår syn på vad framtiden har i sitt sköte, kan dSustainable development relies on our ability to make decisions today that will determine our tomorrow. Given that uncertainty is explicitly allowed to influence our view of what the future holds for us, most ex ante analyses of challenges for sustainable development can be viewed as analysing risk. Many frameworks for analysing risk exist today, but analysing risk for sustainable development enta

We demonstrate a plasma discharge which is generated between two diverging electrodes and extended into a gliding arc in non-equilibrium condition by an air flow at atmospheric pressure. Effects of the air flow rates on the dynamics, ground-state OH distributions and spectral characterization of UV emission of the gliding arc were investigated by optical methods. High-speed photography was utilize

We introduce the notion of random self-decomposability and discuss its relation to the concepts of self-decomposability and geometric infinite divisibility. We present its connection with time series autoregressive schemes with a regression coefficient that randomly turns on and off. In particular, we provide a characterization of random self-decomposability as well as that of marginal distributio