How good writers develop their writing : An experimental study on writing processes and written products

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Joachim Koester Institut d’art contemporain

Joachim Koester: In the Face of Overwhelming Forces

Joachim Koester, Frieze Magazine

Joachim Koester: In the Face of Overwhelming Forces

Joachim Koester: Blueproject Foundation

Lots of flickering happening in Joachim Koester’s Message from Andrée

Joachim Koester: Stills Edinburgh

Joachim Koester, From the Secret Garden of Sleep

Geant4-aided Quantum State Selective Decay Spectroscopy of ²¹³Ra

Utilizing the excellent mass resolving power of SHIPTRAP and the charged-particle-g multicoincidence setup TASISpec, the decay path of the 213Ra ground state can be exclusively studied. Based on virtual experiments with Geant4 it is possible to refine the a-branching ratios of the 213Ra ground state as well as g-ray branching ratios in the 209Rn daughter. The present study provides a proof of conc

Role Of The Delta Resonance In The Population Of Excited States In High-Energy Reactions

The 54Fe nucleus was populated from a 56Fe beam with an energy of E=A=500 MeV. The internal decay of the 10+ metastable state via g-ray emission was observed. The structure of this isomeric state has to involve at least four unpaired nucleons, therefore it cannot be populated in a simple two-neutron removal reaction from the ground state of 56Fe, and we suggest that it was populated via the decay

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

A series of racemic aryl-substituted phenylalanines was synthesized and evaluated in vitro at recombinant rat GluA1-3, at GluK1-3, and at native AMPA receptors. The individual enantiomers of two target compounds, (RS)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid 37 and (RS)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid 38, were characterized. (S)-37 and (R)-38 were id

Acetylcholine-binding protein engineered to mimic the alpha4- alpha 4 binding pocket in alpha 4beta2 nicotinic acetylcholine receptors reveals interface specific interactions important for binding and activity

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3, 4-dihydro-2 H-1, 2, 4-benzothiadiazine 1, 1-dioxide scaffold

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors : unique role of halogen bonding revealed

The α4β2 subtype of the nicotinic acetylcholine receptor has been pursued as a drug target for treatment of psychiatric and neurodegenerative disorders and smoking cessation aids for decades. Still, a thorough understanding of structure-function relationships of α4β2 agonists is lacking. Using binding experiments, electrophysiology and x-ray crystallography we have investigated a consecutive serie

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface of the LBD (ligand-binding domain) and stabilize the agonist-bound conformation slowing receptor desensitization and/or deactivation. In the present study, we employ isothermal titr