Barn och unga lever i en värld där de riskerar att möta svårigheter som kan påverka deras hälsa och utveckling negativt. Interventioner för att stärka barns motståndskraft behövs för att skydda mot negativa konsekvenser rotade i utmaningar under uppväxten. Traumamedveten omsorg (TMO) är en psykoedukativ intervention, som ges till vuxna i barnets närmiljö. Tidigare forskning har undersökt TMO utifrIn today’s society, children and adolescents face adversities that can impair their mental health and psychological development. Interventions that aim to strengthen children’s resilience are crucial in order to protect children from detrimental outcomes. Trauma-Informed Care (TIC) is a psychoeducational intervention, which is administered to adults in children’s environments. Previous research ha

Mångfalden av våtmarker, vattendrag, sjöar och grundvatten samverkar i ett större perspektiv inom ett avrinningsområde. Funktioner som är sammankopplade och beroende av varandra. En holistisk förståelse av våtmarker utgår från att vi tar hänsyn till alla delar. En funktion forskarna i denna rapport benämner hydrodiversitet. Forskarna har undersökt hur stor nyttan är ur ett hydrologiskt och ekonomiThis report presents our research project EcoDiver, funded by the Swedish Environmental Protection Agency. The project was conducted as a collaboration between Lund University and the Royal Institute of Technology (KTH).The main thesis has been hydrodiversity, where the diversity of hydrological units, such as wetlands, lakes, rivers and groundwater, within a catchment area interact and affect the

INTRODUCTION: Mental health service users often have sensory processing difficulties hampering their ability to cope with mental health problems and occupational engagement. However, there is little knowledge of sensory processing and its relation to these factors. Hence, this current study aims to investigate sensory processing patterns in relation to coping and occupational engagement for the ta

Background: Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviate motor symptoms in Parkinson´s disease (PD). In some patients, deterioration of graft function occurred several months after observing a graft-derived functional improvement. Rejection of peripheral

Collaboration with Swedish trio Kv.Arken. Premiere of the piece "Sånger från Svartsten" written specifically for the trio’s unique composition, drawing inspiration from both Swedish and Ukrainian folk tunes. Mats has found inspiration for the work from, among other things, Gammelsvenskby and the Jewish klezmer tradition in Ukraine, as well as from the farm Svartsten in Gåsborn in Värmland, where h

There are sex differences in microglia, which can maintain sex-related gene expression and functional differences in the absence of circulating sex steroids. The angiotensin type 2 (AT2) receptors mediate anti-inflammatory actions in different tissues, including brain. In mice, we performed RT-PCR analysis of microglia isolated from adult brains and RNA scope in situ hybridization from males, fema

This open access handbook aims to constitute a reference point on political norm dynamics in Southeast Asia, by bringing together the array of normative repertoires that frame the possibilities for citizens to participate in, set agendas for, make decisions in, and contest, not only electoral and institutional politics but also informal and imaginary political spaces. It sheds light on intersectin

OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail

Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter

Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor that activates the antioxidant cellular defense in response to oxidative stress, leading to neuroprotective effects in Parkinson's disease (PD) models. We have previously shown that Angiotensin II (AngII) induces an increase in reactive oxygen species (ROS) via AngII receptor type 1 and NADPH oxidase (NOX), which may activate the

Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the brain. We previously showed the presence of PRR in neurons and glial cells in the nigrostriatal system of rodents and primates, including humans.

The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the ro

Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson’s disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathways and molecules involved in the neuroprotective effect of MSCs. We analyzed the

A major limiting factor for cell therapy in Parkinson's disease is the poor survival and reinnervation capacity of grafted dopaminergic neurons, independently of the cell source. Mesenchymal stromal cells (MSCs) have high capability to regulate the local environment through the release of trophic, antiapoptotic and immunomodulatory factors. In this work, we investigated whether co-grafting of MSCs

This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viabilit

Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the above-mentioned AT1-related effects in the aged brain, particularly substantia nigra, was investigated in this study. In the nigra, we observed a progressive decrease in AT2 mRNA expression with aging, and AT2 deletion led to c

Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-Tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-Term use. Cel

Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that or-chestrates the cellular res

I tidigare forskning inom strategisk kommunikation har klimatförändringar undersökts utifrån ett rationellt sätt att kommunicera olika politiska, företagsmässiga eller vetenskapliga intressen. Dessa studier förhåller sig ofta till känslor som antingen psykologiska effekter av planerad kommunikation eller som redan existerande faktorer vilka påverkar förståelsen av frågan. I dessa studier anses denPrevious research has studied the strategic communication of climate change as a rational and purposeful means of communicating about climate change in accordance with political, corporate or scientific interests. These studies often consider emotions either as the psychological effects of planned communication, or as pre-existing attachments that influence an individual's understanding of the iss