The design and fabrication of a combined electrochemical-cantilever microfluidic system is described. A chip integrating cantilevers with electrodes into a microchannel is presented with the accompanying polymer flow cell. Issues such as electrical and fluid connections are addressed, electromechanical behavior in ionic solution is investigated, and two uses of the system are demonstrated. First,

Intraductal neoplasms of the pancreas are classified as intraductal tubulopapillary neoplasms (ITPNs) and intraductal papillary mucinous neoplasm (IPMNs) in the current WHO classification. ITPN is a rare tumor and there are only a few cases of ITPN reported in the literature. We present the case of an otherwise healthy 42-year-old male, who presented with upper abdominal pain. He was subsequently

Coherent diffraction imaging (CDI) on Bragg reflections is a promising technique for the study of three-dimensional (3D) composition and strain fields in nanostructures, which can be recovered directly from the coherent diffraction data recorded on single objects. In this paper, we report results obtained for single homogeneous and heterogeneous nanowires with a diameter smaller than 100 nm, for w

Electronic structure of free and neutral Rb and K clusters containing from few tens to few hundred atoms has been studied using synchrotron radiation. Core-level photoelectron spectroscopy has been used to probe the metallic nature of Rb and K clusters. We show that the metallicity exists down to the dimensions of few nanometers. Simultaneously the emergence and evolution of the valence band struc

How is meaning created by a poem? Through the invisible ideas and thoughts conveyed by the text or through the physical presence of book, paper and print? In Bodies of Poems the author argues that the material properties of poetic texts are meaningful in their own right but often ignored and made invisible in poetry criticism. Through a number of examples ranging from the introduction of print tec

In the transition towards a low-carbon society, changes of attitudes and social norms are needed to support new ways of implementing technical solutions and new behaviors and lifestyles. Mobility Management (MM) campaigns have been shown to contribute to changing of mind sets, but to date these campaigns have not been recognized as important parts of a strategic transport policy plan on an overall

Popular Abstract in Swedish Trots ett sunt leverne med regelbunden motion och nyttig mat kan vi inte alltid förhindra risken att drabbas av vissa typer av cancer som till exempel hjärntumörer. Den vanligaste formen av elakartade hjärntumörer heter glioblastoma multiforme och är också den mest aggressiva. Symptomen varierar beroende på tumörens storlek och var i hjärnan den växer, och patienter kanGlioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in

Background: Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is still unknown. Our aim was to study the prognosis of basal-like DCIS in a large pop

Background: Ischemic postconditioning (PostC), reperfusion in brief cycles, is known to induce short-term reduction in infarct size in patients with ST elevation myocardial infarction (STEMI), especially among those with large myocardium at risk (MaR). The aim of the present study was to investigate the long-term effect of PostC on infarct size and left ventricular ejection fraction (LVEF). Method

Tumor development requires angiogenesis and anti-angiogenic therapies have been introduced in the treatment of cancer. In this context, heparan sulfate proteoglycans (HSPGs) emerge as interesting targets, owing to their function as co-receptors of major, pro-angiogenic factors. Accordingly, previous studies have suggested anti-tumor effects of heparin, i.e. over-sulfated HS, and various heparin mi

Thin layers of GaMnAs ferromagnetic semiconductor grown by molecular beam epitaxy on GaAS(001) substrates were studied. To improve their magnetic properties the post-growth annealing procedures were applied, using the surface passivation layers of amorphous arsenic. This post-growth treatment effectively increases the ferromagnetic-to-paramagnetic phase transition temperature in GaMnAs, and provid

Contribution to the Ukrainian intellectual debate on memory politics in relations to the Second World War and OUN leader Stepan Bandera

We report the characterization of human papillomavirus (HPV) subtype 72b of the genus Alphapapillomavirus isolated from an oral rinse sample of a healthy woman. The HPV72b L1 open reading frame (ORF) was 90.2% identical to that of HPV72, indicating a subtype close to the border of a novel HPV type.

Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequenci

Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk

Context. The unusual Mira variable R Hya is well known for its declining period between AD 1770 and 1950, which is possibly attributed to a recent thermal pulse. Aims. The goal of this study is to probe the circumstellar envelope (CSE) around R Hya and to check for a correlation between the derived density structure and the declining period. Methods. We investigate the CSE around R Hya by performi

A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in t