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Background: Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody in development as a once-daily, subcutaneous prophylaxis for patients with haemophilia A or haemophilia B with or without inhibitors. We aimed to assess the efficacy and safety of concizumab in patients with haemophilia A or B without inhibitors. Here we report the results from the confirmatory analysis cutoff. M

Denna berättelse om immunoterapi kombinerad med ultrahypo-fraktionerad strålterapi har sitt ursprung i den kliniska studie som på engelska benämdes "Brain Immune Gene Tumour Therapy" (BRIGTT) som professor Leif G, Salford i Lund initierade strax innan 2000-millienium-skiftet. Ett specifikt tumörvaccin framställdes baserat på tumörceller som han extraherade ur tumörvävnad från den gliom-patient han

The development of immersive visuoauditory media brings to the fore several design challenges concerning cognitive human factors, such as visual perception, embodied interaction, and emotional engagement. With a focus on visual perception, our research emphasises a systematic study of embodied multimodal interaction in immersive settings and provides a cognitive model of visuospatial complexity th

The European Green Deal recognises the importance of addressing the environmental challenges posed by agriculture to meet the global biodiversity and climate agendas. Environmental policymaking is needed to drive and speed up sustainability transitions in agriculture because the environmental consequences of agricultural activities are not generally reflected in production costs and lead to market

A novel approach is introduced to modulate the threshold voltage of organic electrochemical transistors (OECTs) that are fabricated by electropolymerizing the channel material between the source and drain electrodes. To achieve this, we adjust the ratio of two water-soluble tri-thiophene monomers, which share the same backbone, but present either anionic or zwitterionic sidechains, during channel

Background and purpose: Since patients with primary brain tumor are expected to become long-term survivors, the prevention of long-term treatment-induced side effects is particularly important. This study aimed to explore whether symptom experience and symptom distress change over five years in adults with primary brain tumors treated with proton therapy. An additional aim was to explore whether s

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of multisensory stimulation compared to any single sensory intervention or standard care for physical and neurological development in preterm infants.

Background: Cortical contusions are common in moderate-severe traumatic brain injury (TBI). Cortical contusions often expand, potentially causing neuro-worsening several hours to days post-trauma. While contusion expansion (CE) may affect outcome, potential clinical and radiological markers that can predict CE have been insufficiently explored. In the present single-center retrospective observatio

The ease and consistency with which speakers of many languages provide direct judgments about syllable structure has been taken by scholars as evidence that these judgments are accurate and sufficient argumentation for an analysis of syllable structure in descriptive works. This paper questions whether the results of direct elicitation tasks reliably indicate a prosodic domain that is meaningful i

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To evaluate the benefits and harms of olfactory stimulation with different odorants in the NICU for promoting development and preventing morbidity in preterm infants.

Aims/hypothesis: The temporal suppression of insulin clearance after glucose ingestion is a key determinant of glucose tolerance for people without type 2 diabetes. Whether similar adaptations are observed after the ingestion of a mixed-macronutrient meal is unclear. Methods: In a secondary analysis of data derived from two randomised, controlled trials, we studied the temporal responses of insuli

Something that all Nordic countries have in common is that journalistic work, popular culture phenomena and public debates resulting in subsequent political initiatives have served as driving forces in the development of academic research on the Holocaust. It is also clear that the field is heavily politicized, imbued with moral questions and highly diversified.The memories of the Holocaust have i

The complexity and dynamicity of microservice architectures in cloud environments present substantial challenges to the reliability and availability of the services built on these architectures. Therefore, effective anomaly detection is crucial to prevent impending failures and resolve them promptly. Distributed data analysis techniques based on machine learning (ML) have recently gained attentionThe complexity and dynamicity of microservice architectures in cloud environments present substantial challenges to the reliability and availability of the services built on these architectures. Therefore, effective anomaly detection is crucial to prevent impending failures and resolve them promptly. Distributed data analysis techniques based on machine learning (ML) have recently gained attention

The interaction between a low angle grain boundary in front of a crack tip and the emerging plasticity from the tip of a microstructurally short edge crack subjected to fatigue loading has been studied. The modeling rests solely on discrete dislocations, were the geometry is described by dislocation dipole elements in a boundary element approach and the plasticity, restricted to one slip plane, to