IgE switching requires the prior induction of CE germline transcripts which is mediated by the concerted binding of STAT-6 and NF kappaB to the CE promoter. These transcription factors are regulated by IL-4 and CD40, respectively. However the latter can effect other signaling pathways and the present study explores the role of p38 MAPK in induction of CE germline transcripts. CD40 and IL-4, both a

Many studies have been published about giving and receiving bad messages. However, only a few of them have followed the patients all the way through a disease as is done in this study. Many studies have been written about patients' coping strategies. In this study we will keep within the bounds of coping through information only. The aim of the study is to investigate patients' views of informatio

Popular Abstract in SwedishVad är barnets bästa i en domstolsprocess? Hur skall barns behov och intressen tillvaratas under utredningsarbete och beslut, och av vem? I vilken utsträckning skall barn få komma till tals, och varför? Under senare år har barns rättsliga ställning inom olika områden tilldragit allt större intresse inom rättsvetenskapen, bland rättstillämpare och hos allmänheten. SverigeThis dissertation deals with the question of the child´s legal status in legal proceedings concerning its own person. Special problems that may arise in investigations concerning the situation of the child and in decisions on measures to be taken in the best interest of the child are also examined. The Care of Young Persons Act (1990:52) constitutes the framework of this study. According to the Ac

Popular Abstract in Swedish Riskanalys och insatsplanering är viktiga delar av ett riskhanteringsarbete. Denna studie har visat att det är möjligt att använda brandtekniska ingenjörsmodeller för att bedöma utvecklingen av bränder och det uppkomna behovet av släckmedel. Brandkårsdata från London användes för att studera sambandet mellan brandstorleken och räddningstjänstens insats. Dessa data, tillRisk analysis and intervention planning are important in fire prevention and risk management strategies. This study has shown that it is possible to use fire safety engineering models to estimate the development of fires on a realistic scale, and the corresponding requirement for extinguishing media. Data from the London Fire Brigade (UK) were used to investigate a possible correlation between the

The use of cancer biomarkers to anticipate the outlines of disease has been an emerging issue, especially as cancer treatment has made such positive steps in the last few years. Progress in the development of consistent malignancy markers is imminent because advances in genomics and bioinformatics have allowed the examination of immense amounts of data. Osteopontin is a phosphorylated glycoprotein

There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry approximate to10 000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust. In conjunction with this discordance between our ancient, genetically determined biology and the nutrit

We present a viewpoint of the transport process in quantum cascade laser structures in which spatial transport of charge through the structure is a property of coherent quantum mechanical wave functions. In contrast, scattering processes redistribute particles in energy and momentum but do not directly cause spatial motion of charge.

OBJECTIVE: To investigate whether patients with severe radiographic osteoarthritis (OA) have a different outcome at one year after total hip replacement than patients with moderate radiographic OA. To investigate sex related differences in preoperative radiographic and self reported status and in postoperative outcome.METHODS: 184 patients (96 women) with a mean age at surgery of 71.4 years (50-92

A short introductory analysis of, with translated extracts from, an original Chinese so-called public diary from the Cultural Revolution.

Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) which is thought to arise from a breakdown of immunological tolerance in CD4 cells. The aim of this thesis is to improve our understanding of regulation mechanisms of T cell-dependent chronic inflammation in the CNS and explore ways to overcome the onset and progression of the disease, which can be an importa

High-spin states of a number of nuclei near Ni-56 have been studied by means of the Si-28(Ar-36,x alpha ypzn) reaction. The GAMMASPHERE array in conjunction with light charged particle and neutron detectors were used to identify and cleanly select the fusion-evaporation products. In addition to significantly extending the level schemes of many previously known N = Z nuclei from Fe-52 to Cu-58, exc

The aqueous gallium(III)-acetate system was studied in 0.6 M Na(Cl) at 25 degreesC using a multi-technique approach, including potentiometry, IR spectroscopy, EXAFS spectroscopy and molecular orbital calculations. The potentiometric data were satisfactorily explained by a model which includes one mononuclear and one binuclear complex. The corresponding equilibrium constants defined according to th

The present work studies the separated flow in a square channel with ribs on one wall by using the PIV method. In this study, the spacing between ribs is kept constant and the heights of rib are varied in order to investigate the influence of the pitch-to-height ratio, P/e on the flow structures. Depending on the various pitch ratios, the enclosure between ribs can be regarded as closed or open ca