The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production in cells for bioprocessing have failed as lactate

This study aims to investigate how girls within SiS special residential homes for youths are constructed in Swedish news media. The study is based on the social constructivist perspective and Yvonne Hirdman's gender theory. The theory choices have been made to make visible how words in news media construct both gender and the overall image of girls within SiS special residential homes for yout

Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases

INTRODUCTION: Numerous studies have characterised trajectories of asthma and allergy in children using machine learning, but with different techniques and mixed findings. The present work aimed to summarise the evidence and critically appraise the methodology.METHODS: 10 databases were searched. Screening, data extraction and quality assessment were performed in pairs. Trajectory characteristics w

Parkinson's disease (PD) is characterised by severe degeneration of dopamine (DA) neurons innervating the striatum. Spiny projection neurons (SPNs), are the principal type of striatal neuron and belong to either of two classes: the D2 receptor-positive indirect pathway SPNs (iSPNs) and the D1 receptor-positive direct pathway SPNs (dSPNs). The thesis aims at investigating dynamic changes of SPNs an

As part of the implementation of the Comprehensive Refugee Response Framework and the Global Compact on Refugees we are witnessing the promotion of refugee responses aimed at creating an enabling environment for sustainable investments. This marks a paradigmatic shift “from funding to financing” which sees the role of financial markets becoming central to the way in which refugee responses are man

The cooperative interplay between the functional devices of a preorganized active site is fundamental to enzyme catalysis. An in-depth understanding of this phenomenon is central to elucidating the remarkable efficiency of natural enzymes and provides an essential benchmark for enzyme design and engineering. Here, we study the functional interconnectedness of the catalytic nucleophile (His18) in a

Included in 'Peter Sheppard Skærved’s Knowledge Exchange Violin'. A project that brings together historic instruments, composers, nature , painting, ecologists, architecture, and much more.Krämarkapellet/The Chapel (US Premiere)The piece 'Eroded Memories of Heaven and Beyond' (inspired by Krämarkapellet in Petri Kyrka) was performed by Peter Sheppard Skærved, solo violin

Recent years have seen an explosion of interest in understanding the physicochemical parameters that shape enzyme evolution, as well as substantial advances in computational enzyme design. This review discusses three areas where evolutionary information can be used as part of the design process: (i) using ancestral sequence reconstruction (ASR) to generate new starting points for enzyme design eff

We need more openness about age-related infertility as it is a particular risk for many female scientists in academia who feel that they have to delay having children.

We uncover a critical side-channel vulnerability in the Hamming Quasi-Cyclic (HQC) round 4 optimized implementation arising due to the use of the modulo operator. In some cases, compilers optimize uses of the modulo operator with compiletime known divisors into constant-time Barrett reductions. However, this optimization is not guaranteed: for example, when a modulo operation is used in a loop the

In South Korea, feminism is more than just a controversial topic.

An increasingly large part of the population in the West identifies as religious Nones. Contrary to what might be assumed, most of them are not outright atheists. They reject traditional religion, but many pursue different forms of spirituality, and many entertain supernatural ideas. This element concerns the worldview of these “semi-secular” Nones. When asked about whether they believe in God, th

What identity does the post-2000s Inland Tibet Class (ITC) generation mean? How do Sinophone-Tibetan films articulate the expression of such identity? How does affective visuality mediate the cultural, political, and gender identity formation of female artists of the post-2000s ITC generation?Jinyan Zeng, a researcher at the Centre for East and South-East Asian Studies, Lund University, Sweden, in

BACKGROUND: The coronavirus disease 19 (COVID-19) pandemic has spread globally, causing extensive illness and mortality. In advance of effective antiviral therapies, countries have applied different public health strategies to control spread and manage healthcare need. Sweden has taken a unique approach of not implementing strict closures, instead urging personal responsibility. We analyze the res

Characterizing the adaptive landscapes that encompass the emergence of novel enzyme functions can provide molecular insights into both enzymatic and evolutionary mechanisms. Here, we combine ancestral protein reconstruction with biochemical, structural and mutational analyses to characterize the functional evolution of methyl-parathion hydrolase (MPH), an organophosphate-degrading enzyme. We ident

Recension av Merit Hemmingsons konsert på Malmö Live