Purpose: Many centers aim to plan liver transarterial radioembolization (TARE) with dosimetry, even without CT-based attenuation correction (AC), or with unoptimized scatter correction (SC) methods. This work investigates the impact of presence vs absence of such corrections, and limited spatial resolution, on 3D dosimetry for TARE. Methods: Three voxelized phantoms were derived from CT images of

Objectives: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients. Design: Incident PAH and CTEPH

Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor

Telomeres are protective cap structures at the ends of the linear eukaryotic chromosomes, which provide stability to the genome by shielding from degradation and chromosome fusions. The cap consists of telomere-specific proteins binding to the respective single- and double-stranded parts of the telomeric sequence. In addition to the nucleation of the chromatin structure the telomere-binding protei

Today’s architecture swarms with concepts of energy and resource efficient buildings. In contrast, vernacular buildings are characterized by low-tech climatic responsive strategies and by their inhabitants’ resource and energy savings practices during construction and operation of their dwellings. That makes vernacular buildings highly relevant to resource efficiency in contemporary building resea

Urban theory has historically situated ethnic commercial strips as an organic extension of nearby ethnic residential enclaving. While this is still a useful way to frame such commercial spaces in many cities, this article argues that some areas of this sort function as a marketable branding mechanism (intended or not) to produce nearby residential gentrification. This article explores the influenc

Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6, inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppre

Arrangements to cooperate on innovation facilitate access to external sources of knowledge. By using panel data derived from the five waves of Community Innovation Survey in the Czech Republic, we examine whether firms engage in these arrangements persistently or rather revert to other behaviour. Econometric estimates of dynamic random effects and multivariate probit models provide strong support

Using panel micro data fro\m Community Innovation Survey in the Czech Republic, Norway and the UK, we estimate dynamic random effects models, in which the innovation output of firms is the function of their cooperative behaviour and other observed characteristics, while accounting for unobserved heterogeneity. The results indicate that the capacity of firms to build on external domestic linkages i

Innovation is often seen as carried out by highly educated labor in R&D intensive companies with strong ties to leading centers of excellence in the scientific world. Seen from this angle innovation is a typical "first world" activity. There is, however, another way to look at innovation that goes significantly beyond this high-tech picture. In this broader perspective, innovation-the attempt

This article discusses actor-network theory (ANT) as an approach in empirical public relations research. It is foremost a methodological reflection, but uses a case study to illustrate key points. The case, published as a full study elsewhere, revolved around the plagiarisms in the PhD-dissertation of former German Defence Minister zu Guttenberg and places special emphasis on the work of anonymous

Background: With a yearly incidence of 56 per 100,000 inhabitants, colorectal cancer (CRC) is one of the most common malignancies in the Western world, representing the third leading cause of cancer-related mortality. Within three years after the diagnosis of CRC, 29% of patients will have developed liver metastases. Liver resection is a possibly curative treatment, and several preoperative strate

Background: The time spent in nursing homes (NHs) by patients with Alzheimer’s disease (AD) might be influenced by many factors, e.g., sociodemographic and clinical characteristics, rate of disease progression, and concomitant disorders. Whether different aspects of cholinesterase inhibitor (ChEI) therapy (drug agent, dose, and duration) affect time spent in NHs has not been investigated. We studi

Continuous cardiac monitoring is usually not performed during hemodialysis treatment, although a majority of patients with kidney failure suffer from cardiovascular disease. In the present paper, a method is proposed for estimating a cardiac pressure signal by combining the arterial and the venous pressure sensor signals of the hemodialysis machine. The estimation is complicated by the periodic pr