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Persistent Genomic Erosion in Whooping Cranes Despite Demographic Recovery
Integrating in-situ (wild) and ex-situ (captive) conservation efforts can mitigate genetic diversity loss and help prevent extinction of endangered wild populations. The whooping crane (Grus americana) experienced severe population declines in the 18th century, culminating in a collapse to ~20 individuals by 1944. Legal protections and conservation actions have since increased the census populatio
Evaluation of a Mitochondrial Polygenic Score for Parkinson's Disease Across Ancestries
Threat to fixation and vision-related quality of life in patients with open-angle glaucoma
Purpose: We aimed to investigate the association between overlapping threat to fixation (TTF) and vision-related quality of life (VRQoL) in patients with manifest open-angle glaucoma (OAG). Methods: Overall, 316 patients with manifest OAG were recruited from the glaucoma outpatient department of Skåne University Hospital, Malmö, Sweden, between April and December 2018. VRQoL was assessed using the
Medieval timbers in churches of the Swedish province of Västergötland
The Swedish province of Västergötland is home to around 180 churches from the Middle Ages and played an important role in the processes of Christianisation and subsequent state-building of Sweden. The roof structures of these churches act as a window to our past where we can learn information on construction dates and techniques as well as the use of local resources, such as timber. In this joint
Countertransference struggles of mental health psychotherapists
This study explored the struggles of countertransference (i.e., psychotherapist’s feelings and reactions) through interviews with 20 mental health therapists. Thematic analysis resulted in four themes: (1) personal vulnerability activated in the therapeutic relationship, (2) difficult-to-endure or obstructive feelings (e.g., aversion or burdening discomfort), (3) secondary distressing reactions el
OA of the spine and peripheral joints
REMINISCE : Refurbishment of mirrors to increase sustainability at light sources
Contamination or damage to X-ray optics is becoming increasingly problematic for beamlines at 3rd and 4th generation storage-rings and FEL sources. Carbon contamination, induced by ultra-intense photon-beams, can cause a major loss in flux, focusing power, and specific absorptions which are detrimental to spectroscopy. For new light sources, with higher coherence, intensity, and repetition rates,
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An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies
Introduction: Cytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes. Results/Methods: By combining immunotoxicology and systems biology approaches, we offer a novel and integrative conceptual model of CRS as an adverse outcome (AO), induce
Principal instructional leadership and teacher collaboration : A longitudinal study of the influence on pupil achievement
We study the effects of principal instructional leadership on pupil educational achievement using longitudinal data of 120,394 teacher responses across 1919 schools in Sweden over 9 years. Through multilevel structural equation modelling, we test how teacher ratings of principal leadership influence indicators of educational achievement and the extent to which this effect is channelled through a c
Volcanoes and beyond : Japanese palaeo-disaster studies in global perspective
Located on the Pacific Ring of Fire, the extended Japanese archipelago is among the most geologically hazardous zones for human habitation located anywhere on the planet. Despite these threats and challenges, Japan has supported a series of unique cultures and societies that have evolved and changed over many millennia. The major existential risks include relentless volcanic eruptions, earthquakes
Capturing breast cancers’ copy-number landscape in routine pathology : Exploiting low-resolution, genome-wide sequencing to identify HRD and beyond
Background: Because breast cancer (BC) is molecularly heterogeneous, diagnosis and treatment will likely benefit from comprehensive genetic profiling. However, routine, high-resolution sequencing is not feasible yet, due to implementation challenges associated with whole-genome sequencing of formalin-fixed paraffin embedded (FFPE) BC samples. Therefore, we explored the potential of an alternative
The structure of the annual migratory flight activity in a songbird
Migratory songbirds have an internal circannual genetic programme that controls the timing and extent of migratory flight activity, as demonstrated by experiments with birds held in cages. We used multisensor data loggers to record the timing and duration of all migratory flights during the annual cycle of 15 free-living individuals of red-backed shrikes Lanius collurio. Annual actograms unexpecte
Plasma tau biomarkers for biological staging of Alzheimer’s disease
A blood biomarker-based staging system for Alzheimer’s disease (AD) could improve the diagnosis, prognosis and identification of individuals most likely to benefit from specific therapies. Here, using targeted mass spectrometry, we measured six phosphorylated and six nonphosphorylated tau peptides in plasma from two independent cohorts: BioFINDER-2 and TRIAD (n = 689). We also analyzed the ratios
From Livestock to Legumes: Economic Drivers and Barriers in Norway's Agricultural Policy Landscape
Agricultural subsidies and taxation policies in Norway remain heavily skewed toward livestock, reinforcing structural barriers that hinder the transition toward sustainable and plant-based food systems. This study examines how policy drivers and barriers sustain Norway’s meat-dominated agricultural model and limit the development of plant-based production. To address this aim, the thesis investiga
Aligning Circularity and Climate Goals in Swedish Waste Wood Management
This study examines a policy conflict in Sweden regarding the management of post-consumer waste wood, arising from the conflicting objectives of the European Union’s Waste Framework Directive (WFD) and the Renewable Energy Directive (RED). While the WFD prioritizes material recycling and reuse, Sweden’s current practice, directing approximately 90% of its waste wood to energy recovery through wast
Corporate Sustainability Due Diligence Directive: Preparing for a value-driven transformation while dealing with uncertainties
The Corporate Sustainability Due Diligence Directive represents a significant step in the development of sustainability due diligence, with the potential to improve the human rights and environmental impacts of corporations and their supply chains. Although some companies have already begun enhancing their sustainability due diligence in light of the directive, the process is hindered by numerous
Quantum refinement in real and reciprocal space
In order to understand and manipulate biological function at the molecular level, access to high-resolution structures of biological macromolecules is essential, as structure is intimately linked to function. The two main experimental techniques that can achieve atomic, or near-atomic, resolution are crystallography and electron microscopy. Unfortunately, the experimental data alone is typically n
