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Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

Plant-symbiotic Trichoderma fungi attack microorganisms by secreting antibiotic membrane-permeabilising peptaibols such as alamethicin. These peptaibols also permeabilise plant root epidermis plasma membranes (PMs), but mild pretreatment with Trichoderma cellulase activates a unique cellulase-induced resistance to alamethicin (CIRA), via an unknown mechanism. We identify two Arabidopsis genes that

Background: Ovarian cancer presents with non-specific symptoms that make early diagnosis challenging and the prognosis poor. Ovarian and endometrial cancers exhibit similar genomic mutations and biomarker profiles. Endogenous volatile organic compounds (VOCs) are products of metabolic activity. In cancer, metabolites increase due to tumour necrosis, leading to cancer-specific VOC patterns. The aim

The preparation of perovskite solar cells from the liquid phase is a cornerstone of their immense potential. However, a clear relationship between the precursor ink and the formation of the resulting perovskite is missing. Established theories, such as heterogeneous nucleation and lead complex colloid formation, often prove unreliable, which has led to an overreliance on heuristics. Most high-perf

Plant defense responses are mediated by hormones such as jasmonic acid (JA) and salicylic acid (SA). JA and SA are known to trigger a range of different defense responses in model plants but little is described in crops like quinoa. Here, we present the first molecular description of JA and SA signaling at the transcriptomic level in quinoa. The transcriptomes of quinoa cv. Kurmi seedlings treated

Effective coastal exposure assessments are crucial for adaptively managing threats from sea-level rise (SLR). Despite recent advances, global and regional assessments are constrained by omitting critical factors such as land-use change, failing to disaggregate potential impacts by land uses and oversimplifying land subsidence. Here we address these gaps by developing context-specific scenarios to

Background: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months compared to normocapnia after OHCA. We aimed to est

The detection and classification of adversarial techniques from cyber threat intelligence (CTI) text is a critical task in threat analysis and mitigation. While recent transformer-based models have shown promise, their general-purpose nature often limits effectiveness on complex, domain-specific datasets. In this paper, we present a novel model designed to address the challenges of technique class

Besides their central function in respiration, plant mitochondria play a crucial role in maintaining cellular homeostasis during stress by providing "retrograde" feedback to the nucleus. Despite the growing understanding of this signaling network, the nature of the signals that initiate mitochondrial retrograde regulation (MRR) in plants remains unknown. Here, we investigated the dynamics and caus

BACKGROUND: Totally implantable venous access ports (TIVAPs) are essential for administering chemotherapeutic drugs and nutritional support, but carry a risk of infectious complications. We hypothesized that the design of the current port needle (Huber) could facilitate the collection of bacteria from the skin during puncture, potentially introducing them into TIVAPs and causing infections. This s

We study two-dimensional, stationary square and hexagonal patterns in the thermocapillary deformational thin-film model for the fluid height h [Formula presented] that can be formally derived from the Bénard–Marangoni problem via a long-wave approximation. Using a linear stability analysis, we show that the flat surface profile corresponding to the pure conduction state destabilises at a critical

In this paper, we present a new generic Structure-From-Motion pipeline, GenSfM, that uses a non-parametric camera projection model. The model is self-calibrated during the reconstruction process and can fit a wide variety of cameras, ranging from simple low-distortion pinhole cameras to more extreme optical systems such as fisheye or catadioptric cameras. The key component in our framework is an a

Allergic contact dermatitis (ACD) is a prevalent inflammatory skin condition triggered by allergens such as 2-methyl-4-isothiazolin-3-one (MI), a common preservative. The incidence of contact allergy to MI has fallen in Europe in recent years, attributable to government regulation limiting concentrations of MI I; however, incidence continues to rise in the USA. The pattern and extent of distributi

Den femte mars i år kom det in en begäran om återlämnande till Historiska museet vid Lunds universitet. Begäran kom in från privatpersoner bördiga från Luleå samt Lule-Boden Sameförening och berör kranier efter två samiska individer.

The electricity market exhibits significant uncertainty arising from rapid fluctuations in prices, variations in load demand, and the intermittent nature of renewable energy resources. Effectively managing residential energy under these dynamic conditions is a challenging task. Demand Response (DR) offers a practical solution by enabling the flexible scheduling of energy consumption in response to

Given ongoing debates about the nature and consequences of religious belief, effective procedures for experimentally controlling such beliefs are highly desirable. To date, however, there are few robust, replicable methods. Here, we show that the “choice blindness” paradigm can be leveraged to directly manipulate religious beliefs and attitudes in a way that avoids demand characteristics. Across t

I denna studie undersöktes översvämningsrisker i ett område i Rwandas huvudstad Kigali genom mätningar, observationer och modellering av ytvatten i programvaran HEC-RAS. De huvudsakliga resultaten från studien visade att mycket av den mätdata som samlades in från myndigheter i Kigali var undermåliga för kalibrering av en hydraulisk modell. Bland annat stämde ofta inte flödestoppar i regn och flödeIn this research, 2D hydraulic modelling is applied in the Rwandex-Magerwa catchment to investigate the flood conditions and to quantify needed detention volumes during extreme rainfall. In the calibration uncertainties concerning calibration data were discovered, the total precipitation and outlet flow volumes show large differences, the difference in time between flow and rain peaks intensities

Landskrona är en stad i pulserande förändring. Staden, som har sina historiska rötter i såväl indus triarbete som kolonilotter, har under det senaste de cenniet utmanats med ett allt mer förändrat stadsliv. En stad som tidigare haft svårt att hyra ut sina mest centrala bostäder upplever nu ett ökande intresse för att bo och vistas i staden. En förändring som, om än synlig idag, kommer fortsat

Who conducts biological research, where they do it and how results are disseminated vary among geographies and identities. Identifying and documenting these forms of bias by research communities is a critical step towards addressing them. We documented perceived and observed biases in movement ecology, a rapidly expanding sub-discipline of biology, which is strongly underpinned by fieldwork and te

Many birds schedule their activity to a specific phase of the diel (24-h) light–dark cycle. Two notable exceptions are the nocturnal migration of many otherwise diurnal songbirds and the diverse activity patterns of birds during the continuous light above the Polar Circles during summer. Assumptions about the phase relationship between migratory activity and the diel cycle can be incorrect, and th