Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to target underlying pathophysiological mechanisms. The DNA repair protein 8-oxoguanine DNA glyc

While the design of goods and services is undeniably important in cultivating customer engagement (CE) with industrial innovations, the theoretical interface of industrial design, innovation, and CE remains nebulous, exposing an important literature-based gap. Relatedly, while the literature has focused on the firm as the focal designing stakeholder, further knowledge building is needed regarding

This chapter discusses developments of GIIU in different ways. As the chapter tries to outline possible lines of future research, it is by nature exploratory, on the verge of being speculative. We discuss the issue when the bias depends on the score in a non-linear way and outline a test to detect different type biases of this kind. We also discuss issues where candidates are awarded multiple scor

BACKGROUND: In contrast with macroorganisms, that show well-documented biogeographical patterns in distribution associated with local adaptation of physiology, behavior and life history, strong biogeographical patterns have not been found for microorganisms, raising questions about what determines their biogeography. Thus far, large-scale biogeographical studies have focused on free-living microbe

Traffic models are a useful tool for evacuation planning and management in case of wildfires. Despite the availability of several evacuation models, the number of datasets that can be used for their calibration and validation is limited. This paper presents key traffic flow data collected during the 2019 Kincade Fire. The data (69 116 data points from 24 locations) have been sourced from the Perfo

A young man presented unconscious with severe hyponatraemia, hypokalaemia, hypomagnesaemia and metabolic alkalosis. After 4 months of treatment in hospital, the hypomagnesaemia persisted. The patient had no signs of diabetes mellitus, and radiology showed no abnormalities of the kidneys, pancreas or genitourinary tract. A parenteral magnesium load demonstrated renal wasting with increased fraction

BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content. METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segme

We report on the discovery of three transiting planets around GJ 9827. The planets have radii of 1.75±0.18, 1.36±0.14, and 2.11 0.21 0.22 - + R⊕, and periods of 1.20896, 3.6480, and 6.2014 days, respectively. The detection was made in Campaign 12 observations as part of our K2 survey of nearby stars. GJ 9827 is a V = 10.39 mag K6V star at a distance of 30.3±1.6 parsecs and the nearest star to be f

HD 3167 is a bright (V = 8.9 mag) K0 V star observed by NASA's K2 space mission during its Campaign 8. It has recently been found to host two small transiting planets, namely, HD 3167b, an ultra-short-period (0.96 days) super-Earth, and HD 3167c, a mini-Neptune on a relatively long-period orbit (29.85 days). Here we present an intensive radial velocity (RV) follow-up of HD 3167 performed with the

We confirm the planetary nature of two transiting hot Jupiters discovered by the Kepler spacecraft's K2 extended mission in its Campaign 4, using precise radial velocity measurements from FIES@NOT, HARPS-N@TNG, and the coudé spectrograph on the McDonald Observatory 2.7 m telescope. K2-29 b (EPIC 211089792b) transits a K1V star with a period of 3.2589263 ± 0.0000015 days; its orbit is slightly ecce

Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims. We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods. We used the transit light curve to characterize the planetary parameters relative to the stel

We report the discovery of one super-Earth- (TOI-1749b) and two sub-Neptune-sized planets (TOI-1749c and TOI-1749d) transiting an early M dwarf at a distance of 100 pc, which were first identified as planetary candidates using data from the TESS photometric survey. We have followed up this system from the ground by means of multiband transit photometry, adaptive optics imaging, and low-resolution

MODY3 is a monogenic hereditary form of diabetes caused by mutations in the transcription factor HNF1A. The patients progressively develop hyperglycemia due to perturbed insulin secretion, but the pathogenesis is unknown. Using patient-specific hiPSCs, we recapitulate the insulin secretion sensitivity to the membrane depolarizing agent sulfonylurea commonly observed in MODY3 patients. Unexpectedly

4-1BB (CD137) is an activation-induced costimulatory receptor that regulates immune responses of activated CD8 T and natural killer cells, by enhancing proliferation, survival, cytolytic activity, and IFNγ production. The ability to induce potent antitumor activity by stimulating 4-1BB on tumor-specific cytotoxic T cells makes 4-1BB an attractive target for designing novel immuno-oncology therapeu

Engdahl, E. 2023. The church at the end of Värend: A study of Åseda church’s medieval history. Within the forests of Swedish Småland, on the edge of Kronobergs county, lies the village of Åseda. This location has been sparsely studied by various scholars. The parish church in Åseda was subjected to a restoration during 1936-37, led by architect Paul Boberg. This restoration resulted in a lot of ar

A practical procedure for the synthesis of water-soluble, chiral and amphiphilic macrocyclic molecules is described. Acylation of p-xylylene diamine with Fmoc-protected glycine and aspartic acid, followed by removal of the Fmoc moiety afforded amino acid:p-xylene conjugates as free diamines. These diamines were converted to symmetrical and unsymmetrical macrocycles via stepwise urea formation u

A one-pot synthesis of the globotetraose tetrasaccharide is reported. The synthetic method relies on the use of a p-methoxybenzyl ether as an in situ-removable protecting group. N-Iodosuccinimide/trifluoromethanesulfonic acid-promoted glycosylation of 2-bromoethyl-2,3,6-tri-O-benzoyl-4-O-(2,3,6-tri-O-benzoyl-β-D-galactopyranosyl)-β-D-glucopyranoside 5 at −45 °C with phenyl 2,4,6-tri-O-benzyl-3-O-(

Background: Hospital-acquired hyponatremia remains a feared event in patients receiving hypotonic fluid therapy. Our objectives were to assess post-operative plasma-sodium concentration and to provide a physiological explanation for plasma-sodium levels over time in children with acute appendicitis. Methods: Thirteen normonatremic (plasma-sodium ≥135 mmol/L) children (8 males), median age 12.3 (IQ

The present Multi-view stereo (MVS) methods with supervised learning-based networks have an impressive performance comparing with traditional MVS methods. However, the ground-truth depth maps for training are hard to be obtained and are within limited kinds of scenarios. In this paper, we propose a novel unsupervised multi-metric MVS network, named M 3 VSNet, for dense point cloud reconstruction w

Purpose: To present age- and sex-specific cumulative annual incidences of primary traumatic lateral patellar dislocation (LPD) and to detail patient characteristics and concomitant chondral injuries including osteochondral fractures, as visualized on magnetic resonance imaging (MRI), in a large consecutive cohort of knee-injured individuals. Methods: Data on primary traumatic lateral patellar disl