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Using higher rates of stabilization of a wet-spun pan fibre to understand the effect of microstructure on the tensile and compressive properties of carbon fibre

The transformation of a polyacrylonitrile (PAN) precursor fibre into carbon fibre using varying stabilization times during carbon fibre manufacture is presented in this work. The wet-spun precursor fibre is a specifically designed PAN co-polymer made up of acrylonitrile, methyl acrylate and 3 wt% itaconic acid. The residence or stabilization times in the oxidation ovens are varied from 32, 64 and

What resilience theory and praxis can learn from multi-dimensional approaches to understanding poverty : A study of Ghanaian cocoa forest landscapes

Resilience – broadly understood as withstanding, and adapting to, shocks and risks – has emerged as a central discursive device for converging humanitarian needs with climate change responses. This paper's human-centred engagement with resilience draws on the case of smallholder farmers engaged in rain-fed cocoa production in Ghana's Central Region, to systematically unpack how poverty shapes smal

Which electric vehicle charging station to upgrade? Biased judgments based on differences in station efficiency

One way of controlling global warming is to substitute fuel driven cars with electric cars. Electric vehicles need to be charged. For maximal efficiency the charging times should be as short as possible. In the US charging stations are classified as Level 1 charging 5–10 miles/h, Level 2 25 miles/h and Fast DCFC stations 150–1000 miles/h. We asked participants to select one of two upgrades of char

Continuous measurement in neurocritical care of cerebral blood flow (CBF) calculated from ICP and central venous pressure

The cerebral blood flow, CBF, is an important clinical parameter in neuro-intensive care. The possibility to continuously monitor CBF, computed from referential ICP, rICP (calculated from measured intracranial pressure, ICP, and central venous pressure, CVP) and venous outflow resistance, Rv, could importantly improve patient care. For the CBF(1) method the pulsative part of CBF (with rICP increas

Plasma bioactive adrenomedullin predicts mortality and need for dialysis in critical COVID-19

COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the endothelial barrier and has been associated with COVID-19 mortality and other adverse events. This prospective cohort pilot study included 119 consecutive patients with verified SARS-CoV-2 infection admitted to two inten

The beginning of a success story : basalmost members of the extant ophiuroid clade from the Silurian of Gotland, Sweden

Due to the fragility of the ophiuroid (brittle star) skeleton, the bulk of the group’s fossil record consists of dissociated ossicles preserved as microfossils. In spite of their great potential as basis for taxonomic and phylogenetic studies, however, ophiuroid ossicles from the Paleozoic have received very little attention so far. Here, we provide an exhaustive taxonomic assessment of such fossi

Measuring deformation processes in granular materials from intragranular to bulk scales

Granular materials (assemblies of contacting grains with inter-granular porosity) form a vast family of materials important in both natural and industrial contexts. Under mechanical loads such systems show complex behaviours relating to the inter-and intra-granular stresses, strains and force transmission as well as the individual grain kinematics and interactions leading to multi-scale, heterogen

NEPER-MOSAIC : Seamless generation of periodic representative volume elements on unit domains

The effective macroscopic behaviour of a material is a manifestation of the underlying microstructure and microscale processes. This renders the generation of highly accurate digital microstructure twins indispensable for multiscale simulations. MOSAIC is a Python-based, open-source software tool designed to address the challenge of incorporating non-planar, periodic microstructures generated by t

GCNPMDA : Human microbe-disease association prediction by hierarchical graph convolutional network with layer attention

Microorganisms play a crucial role in various physiological processes, including metabolism, immune defense, nutrition absorption, defense against cancer, and protection against pathogen colonization. Changes in microbial communities serve as potential biomarkers for diseases, offering significant insights into disease treatment and diagnosis. However, the association between microorganisms and di

Exploring serial crystallography for drug discovery

Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today - conventional X-ray crystallography - is that it only provides structural infor

Fathers’ Experiences Six Months After their Preterm Infant's Discharge from the NICU

Although fathers experience emotional stress both during the care period and after discharge, there is limited research focusing exclusively on fathers’ experiences after their time in a neonatal intensive care unit. Their experiences are important for tailoring support to fathers based on their individual needs. This paper is part of a longitudinal study in which parents were followed by means of

A Survey of Preoperative, Perioperative, and Postoperative Management Practices for Testicular Torsion in Pediatric Patients among European Surgeons

Introduction Management of testicular torsion varies between specialties resulting in lack of standardization. The aim of this survey was to assess pre-, peri-, and postoperative differences. Methods An online questionnaire was distributed in 2023 to general and pediatric surgeons, pediatric urologists, and urologists by the Trainees of European Pediatric Surgery. Main Results Among 88 respondents

Tourette syndrome research highlights from 2023

In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.

Associations between adverse childhood experiences and psychological distress among Swedish upper secondary school students

Background: The detrimental impacts of adverse childhood experiences (ACEs) on health have been extensively studied, mainly focusing on the effects of ACEs on adults. However, there is a dearth of studies exploring their influences on adolescents. Objective: This study aims to investigate the associations between ACEs and psychological distress among Swedish adolescents. Participants and setting:

Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort

We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control subjects. Diabetic polyneuropathy was the most common aetiology of neuropathic pain. A standardised quantitative sensory testing protocol was used to categorize

Evaluating the Applicability of a Real-Time Highly Oxygenated Organic Molecule (HOM)-Based Indicator for Ozone Formation Sensitivity at a Boreal Forest Station

Ground-level ozone (O3), formed via complex photochemistry involving nitrogen oxides (NOx) and volatile organic compounds (VOCs), is a critical secondary pollutant and oxidant. Therefore, understanding whether the formation of O3 is NOx- or VOC-limited is essential for effective air quality management. Recently, we demonstrated that the distribution of highly oxygenated organic molecules (HOMs) ca

Navigating Health Applications Realms : Consent Challenges and User Empowerment in European Law

This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl

Behavioral manifestations of executive functioning in Swedish youth with ADHD, autism, and psychiatric comorbidity: a comparative analysis with community controls

While several rating scales reliably and cost-effectively assess behavioral executive functioning (EF) in youths with neurodevelopmental disorders (NDDs), questions remain about the impact of comorbidities and dual NDDs on EF as measured by these scales in clinical samples. This study compared behavioral EF profiles among youths with NDDs, both with and without psychiatric comorbidities, non-NDDs