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Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine
Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) can additionally sensitize human cancer cell lines towards the anti-cancer drug gemcitabine. We show that this property is based on the Dm-dNK ability to efficiently phosphorylate gemcitabine. The 2.2 angstrom resolution structure of DmdNK in complex with gemcitabine shows that the residues Tyr70 and Arg105 play a crucial r
Hydroxyapatite as a novel reversible in situ adsorption matrix for enzyme thermistor-based FIA
The application of the easily available and inexpensive chromatographic matrix hydroxyapatite for reusable and reversible immobilization of enzymes for enzyme thermistor-based flow injection analysis of glucose and Urea was tested. The immobilization was achieved by simple affinity adsorption of glucose oxidase and urease by a suitable pH-induced alteration of the protein charge. A linear detectio
Adsorption of Trimethyl Phosphate on Maghemite, Hematite, and Goethite Nanoparticles
Adsorption of trimethyl phosphate (TMP) on well-characterized hematite, maghemite and goethite nanopartides was studied by in situ DRIFT spectroscopy as a model system for adsorption of organophosphorous (OP) compounds on iron minerals. The iron minerals were characterized by X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS)
Optimal Migration Strategies in Bats
This paper introduces some theoretical concepts based on optimality theory that may be applied to bat migration. Most predictions are based on flight mechanics and potential flight range. Optimal behavior will depend on the relevant immediate currency, such as safety, time, or energy. Predictions concern optimal flight speeds, stopover duration, fuel load at departure, and the adaptive use of wind
On the H2 Decentralized Controller Synthesis for Delayed Bilateral Teleoperation Systems
Procedure for the synthesis of decentralized controllers for delayed bilateral teleoperation systems is proposed, based on the analytical solution of a global H2 optimization. Explicit state-space formulae for the optimal controller are presented. The controller possesses a neat structure, which preserves closed-loop stability regardless of the delay length. The behavior of the resulting teleopera
A 0.7 to 3 GHz wireless receiver front end in 65-nm CMOS with an LNA linearized by positive feedback
This paper presents a wireless receiver frontend intended for cellular applications implemented in a 65 nm CMOS technology. The circuit features a low noise amplifier (LNA), quadrature passive mixers, and a frequency divider generating 25 % duty cycle quadrature local oscillator (LO) signals. A complementary common-gate LNA is used, and to meet the stringent linearity requirements it employs posit
Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: A nationwide study
Objective. Autoimmune hepatitis (AIH) is a chronic liver disease, which if untreated can lead to cirrhosis and hepatic failure. The aim of the study was to investigate the incidence, prevalence, diagnostic tradition and clinical initial presentation of AIH. Material and methods. Analyses were performed in 473 patients identified as having probable or definite AIH. Results. The incidence of AIH was
Time characteristics of the effect of alcohol cessation on the risk of stomach cancer a meta-analysis
Background: In the Bagnardi et al. (2001) meta-analysis, it was found that alcohol consumption increases the risk of stomach cancer (OR = 1.32 for heavy drinkers). However, it is unknown if drinking cessation reverses this alcohol-elevated risk. Methods: A systematic literature review was performed to provide the information for a meta-analysis where the dose-risk trend was estimated for years sin
Kohn-Sham density functional theory for quantum wires in arbitrary correlation regimes
We use the exact strong-interaction limit of the Hohenberg-Kohn energy density functional to construct an approximation for the exchange-correlation term of the Kohn-Sham approach. The resulting exchange-correlation potential is able to capture the features of the strongly correlated regime without breaking the spin or any other symmetry. In particular, it shows "bumps" (or barriers) that give ris
Calcium mediated interaction of calf-thymus DNA with monolayers of distearoylphosphtidylcholine: a neutron and Xray reflectivity study
X-ray and neutron reflection studies, the latter in conjunction with contrast variation, have been combined to study the interaction of calf thymus DNA (ctDNA) with monolayers of distearoylphosphatidylcholine (DSPC) in the presence of 20 mM Ca2+ ions, at the air–liquid interface as a function of surface pressure (10, 20, 30 and 40 mN m−1). Analysis of the X-ray and neutron reflection data showed t
Use of a trabecular metal implant in ankle arthrodesis after failed total ankle replacement
Patients and methods 13 patients with a migrated or loose total ankle implant underwent arthrodesis with the use of a retrograde intramedullary nail through a trabecular metal Tibial Cone. The mean follow-up time was 1.4 (0.6-3.4) years. Results At the last examination, 7 patients were pain-free, while 5 had some residual pain but were satisfied with the procedure. 1 patient was dissatisfied and e
Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS - A Novel Therapeutic Opportunity.
ClinicalTrials.gov NCT01802697.
Malnutrition and risk of falling among elderly without home-help service - A cross sectional study
Objectives: The aim of this study was to explore the frequency of malnutrition risk and associated risk of falling, social and mental factors among elderly without home-help service. The aim was also to explore factors associated with risk of falling. A cross-sectional design was used. Elderly persons own homes. Data were collected during preventive home visits to 565 elderly (age range 73-90 year
The intrinsic GTPase activity of the Gtr1 protein from Saccharomyces cerevisiae
Background: The Gtr1 protein of Saccharomyces cerevisiae is a member of the RagA subfamily of the Ras-like small GTPase superfamily. Gtr1 has been implicated in various cellular processes. Particularly, the Switch regions in the GTPase domain of Gtr1 are essential for TORC1 activation and amino acid signaling [R. Gong, L. Li, Y. Liu, P. Wang, H. Yang, L. Wang, J. Cheng, K. L. Guan, Y. Xu, Genes De
Review of Peter Longerich, "Heinrich Himmler. En biografi"
The variation of daylight levels across atrium walls: Reflectance distribution and well geometry effects under overcast sky conditions
Daylight plays a major role in making atrium spaces appealing to building users. This appeal is also evident in the spaces adjoining the atrium. A key component of atrium daylighting, especially in tall atria, is the daylight reflected on to the atrium walls. This study examines the impacts of well geometries and different diffuse reflectance distributions of walls on variations of vertical intern
Chairmen's Foreword: beta-blockade across the cardiovascular continuum-when and where to use?
Assessing ozone exposure for epidemiological studies in Malmo and Umea, Sweden
Ground level ozone [ozone] is considered a harmful air pollutant but there is a knowledge gap regarding its long term health effects. The main aim of this study is to develop local Land Use Regression [LUR] models that can be used to study long term health effects of ozone. The specific aim is to develop spatial LUR models for two Swedish cities, Umea and Malmo, as well as a temporal model for Mal