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Incremental Evaluation of Reference Attribute Grammars using Dynamic Dependency Tracking

Reference attribute grammars (RAGs) have proven practical for gen- erating production-quality compilers from declarative descriptions, as demonstrated by the JastAdd system. Recent results indicate their applicability also to generating semantic services in interactive editors. For use in editors, it is necessary to update the attribution after edit operations. Earlier algorithms based on statical

Retinol-Binding Protein 4 in Twins Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action

OBJECTIVE-Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism. RESEARCH DESIGN AND METHODS-The s

Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. The red blood cells are responsible for transporting oxygen throughout the body, while the myeloid and lymphoid cells are essentially required for immune responses. The HSCs reside in special niches in t

On Leukocyte Recruitment in Cholestatic Liver Injury

Cholestasis is a frequent clinical syndrome, which is caused by a dysfunction in bile formation of the hepatocyte or from obstruction of the biliary tract. This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment has emerged as a key feature. Therefore, the aim of this thesis was to analyze the detailed mechanis

Low molecular mass proteins as markers for renal function and dialysis efficiency

Kidney disease is a growing problem in the whole world. It is important to find these patients in an early state of the disease because then they can be treated and dialysis treatment can be avoided. To measure the glomerular filtration rate (GFR) an invasive technigue is used. In this thesis an equation to estimate GFR (eGFR) by drawing a blood sample and measure the concentration of cystatin C i

Coeliac disease-specific tissue transglutaminase autoantibodies are associated with osteoporosis and related fractures in middle-aged women

Objective. To investigate whether the serological marker for coeliac disease, tissue transglutaminase autoantibody (tTGAb), is associated with decreased bone mass density (BMD) and increased frequency of fractures in middle-aged women screened for osteoporosis. Material and methods. The study comprised 6480 women (mean age 56 years, range 50-64) who answered a number of questionnaires and who unde

Signature of superconductivity in UBe13 as seen by neutron scattering: Superconducting and magnetic energy scales

We here present inelastic neutron scattering results on the strongly correlated cubic superconductor UBe13 (T-c = 0.85 K) obtained on a large single crystal by high-resolution cold neutron three-axis spectroscopy. We observed spin dynamics at a unique momentum space position building up below T similar to 50 K and changing significantly on entering the superconducting state. The observed short-ran

Incidence of Diabetes Mellitus and Evolution of Glucose Parameters in Growth Hormone-Deficient Subjects During Growth Hormone Replacement Therapy A long-term observational study

OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age

Ultrafast Excited State Dynamics of 5,6-Dihydroxyindole, A Key Eumelanin Building Block: Nonradiative Decay Mechanism.

As part of a program designed to elucidate the excited state properties of key eumelanin building blocks, we report herein a study of 5,6-dihydroxyindole (DHI) in phosphate buffer at pH 3 and pH 7 using femtosecond transient absorption spectroscopy. The transient absorption changes following excitation at 266 nm were used to directly monitor relaxation of the excited states. It was found that the

'Needle and Stick' save the world: Sustainable development and the universal child

This text deals with a problem concerning processes of the productive power of knowledge. We draw on so called poststructural theories challenging the classical image of thought – as hinged upon a representational logic identifying entities in a rigid sense – when formulating a problem concerning the gap between knowledge and the object of knowledge. More specifically we are looking at this proble

Geo-mapping of time trends in childhood caries risk - a method for assessment of preventive care

Background: Dental caries is unevenly distributed within populations with a higher burden in low socio-economy groups. Several attempts have been made to allocate resources to those that need them the most; there is a need for convenient approaches to population-based monitoring of caries risk over time. The aim of this study was to develop the geo-map concept, addressing time trends in caries ris

Software Quality Across Borders: Three Case Studies on Company Internal Alignment

Context Software quality issues are commonly reported when offshoring software development. Value-based software engineering addresses this by ensuring key stakeholders have a common understanding of quality. Objective This work seeks to understand the levels of alignment between key stakeholder groups within a company on the priority given to aspects of software quality developed as part of an

Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea

The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, t

Unraveling the similarity of the photoabsorption of deprotonated p-coumaric acid in the gas phase and within the photoactive yellow protein

Using advanced QM/MM methods, the surprisingly negligible shift of the lowest-lying bright electronic excitation of the deprotonated p-coumaric acid (pCA(-)) within the photoactive yellow protein (PYP) is shown to stem from a subtle balance between hypsochromic and bathochromic effects. More specifically, it is found that the change in the excitation energy as a consequence of the disruption of th

Response actions to difficulties in using everyday technology after acquired brain injury

Purpose: People with acquired brain injury (ABI) have difficulties using everyday technology (ET) in daily tasks at home and in society. To support them in managing the demands imposed by using ET, knowledge is needed concerning their response actions to the difficulties. The aim of this study was to explore and describe what characterizes response actions to difficulties using ET, their condition