Background: Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarkers, and the relevance of female hormone signaling in pancreatic or other periampullary adenocarcinoma remains largely unexplored. The aim of this study was to examine the extent a

The prognosis for mantle cell lymphoma (MCL) remains poor. Our aim was to assess the impact of comorbidities on survival and causes of death. For 1,385 MCL patients (1,009 males, 376 females) diagnosed in 2000–2014 (median age 71 years, range 22–96) comorbidities ≤ 10 years of diagnosis were classified according to the Charlson comorbidity index (CCI; 0, 1, 2+). Hazard ratios (HRs) with 95% confid

BACKGROUND: The cultivated peanut (Arachis hypogaea) is one of the most important oilseed crops worldwide, however, its improvement is restricted by its narrow genetic base. The highly variable wild peanut species, especially within Sect. Arachis, may serve as a rich genetic source of favorable alleles to peanut improvement; Sect. Arachis is the biggest taxonomic section within genus Arachis and i

Detta är den nionde skriften i forskningsprogrammet Vetenskap och beprövad erfarenhets (VBE:s) skriftserie om begreppet vetenskap och beprövad erfarenhet. Denna gång är skriften resultatet av ett pågående samarbete med forskningsprogrammet Foresight vid Malmö universitet. Foresights forskning är inriktad på att hitta nya verktyg för att identifiera patienter som löper ökad risk för karies och tand

Attoscience is the emerging field that accesses the fastest electronic processes occurring at the atomic and molecular length scales with attosecond (1 as = 10−18 s) time resolution having wide ranging physical, chemical, material science and biological applications. The quintessential and one of the most fundamental processes in this domain is the generation of phase locked XUV attosecond pulses.

The coastal zone of the Baltic Sea is diverse with strong regional differences in the physico-chemical setting. This diversity is also reflected in the importance of different biogeochemical processes altering nutrient and organic matter fluxes on the passage from land to sea. This review investigates the most important processes for removal of nutrients and organic matter, and the factors that re

Two different versions of an optical theorem for a scattering body embedded inside a lossy background medium are derived in this paper. The corresponding fundamental upper bounds on absorption are then obtained in closed form by elementary optimization techniques. The first version is formulated in terms of polarization currents (or equivalent currents) inside the scatterer and generalizes previou

The chemical evolution of fluorine is investigated in a sample of Milky Way red giant stars that span a significant range in metallicity from [Fe/H] ∼-1.3 to 0.0 dex. Fluorine abundances are derived from vibration-rotation lines of HF in high-resolution infrared spectra near 2.335 μm. The red giants are members of the thin and thick disk/halo, with two stars being likely members of the outer disk

Background: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. Methods: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocr

The chemical composition of fossil foraminiferal shells (tests) is widely used as tracers for past ocean chemistry. It is, therefore, important to understand how different (trace) elements are transported and incorporated into these tests from adjacent seawater. The elemental distribution within the walls of foraminiferal tests might be used to differentiate between proposed transport mechanisms.

There is interest in increasing the consumption of foods with high dietary fiber content due to the health problems associated with its low intake. Plantain (Musa paradisiaca L.) flour (PF) (non-thermostable) and Hi-Maize 260 (HA) (thermostable) were used as resistant starch (RS) sources to elaborate blends with wheat (WF) and rice flours (RF) in a 50:50 ratio. Five blends were prepared (PF-WF, PF

The number of heating and cooling system using vertical borehole heat exchangers is increasingly rapidly in Sweden. Currently, there are over 600,000 installations, mostly using U-tube ground collectors. In recent years, several new ground collectors with innovative designs and configurations have been launched. They claim to have superior performance and competitive advantages over the convention

In this study, a multiphysics model is presented that predicts creep in three months old concrete cylinders subjected to drying. The model includes concrete hydration, and a moisture transport model with relative humidity as the driving potential. These parameters are important to include in order to simulate creep. The model was implemented in the finite element software COMSOL Multiphysics. The

This study presents a multiphysics model developed to predict the internal temperature and moisture development in a concrete reactor containment at an early age. The work is a part of the benchmark study, VeRCoR, provided by EDF. The model was applied on an experimental reactor containment mock-up erected in the vicinity of Paris. The 3D geometry was provided from VeRCoRs. The model includes conc

The chapter integrates physicalist and constructivist approaches to phenomena conventionally categorised as ‘labour’ and ‘energy’ by unravelling how the two entangled concepts reflect nineteenth-century modernity’s increasingly instrumental approach to both society and nature. Energy technologies became understood as the efficient harnessing of nature’s powers in much the same way as economists fo

An in vitro model was developed to characterize the electrical properties of silicon microfabricated recording electrodes, using a Cu-wire mimicing a neural signal source. Phosphorous doped electrodes were used to achieve an all silicon device. The model was used to study signal amplitude as a function of distance between the electrode surface and the signal source. Signal crosstalk to neighbourin

Prioriteringsplattformen formulerar centrala idéer om sjukvårdens mål ochvärden. De kan och bör vara oförändrade, även om förutsättningarna att uppnå demändras. Gränserna för de behov som samhället anser att den offentliga sjukvården ska tillgodose kan ändras utan att de grundläggande målen överges. Plattformen kan bidra till att förbättra förtroendet för den offentligt finansierade hälso- och sjuThe platform for priority-setting contains key ideas about the mission, goals and values of health care in Sweden. The basic idea is that health care resources should be distributed primarily according to need and effect, and secondarily according to cost-effectiveness. Nobody should be discriminated against on the basis of their gender, age, religion, ethnic origin or political views. We also nee