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Non-negative least squares computation for in vivo myelin mapping using simulated multi-echo spin-echo T2 decay data

Multi‐compartment T2 mapping has gained particular relevance for the study of myelin water in the brain. As a facilitator of rapid saltatory axonal signal transmission, myelin is a cornerstone indicator of white matter development and function. Regularized non‐negative least squares fitting of multi‐echo T2 data has been widely employed for the computation of the myelin water fraction (MWF), and t

Impact of Spatially Consistent Channels on Digital Beamforming for Millimeter-Wave Systems: (Invited Paper)

The premise of massive multiple-input multiple-output (MIMO) is based around coherent transmission and detection. Majority of the vast literature on massive MIMO presents performance evaluations over simplified statistical propagation models. All such models are drop-based and do not ensure continuity of channel parameters. In this paper, we quantify the impact of spatially consistent (SC) models

SNAP - POP for Massive MIMO Systems

Massive multiple-input multiple-output (MIMO) has gained a tremendous amount of attention as a key enabler of fifth-generation cellular systems. The majority of the vast literature on massive MIMO is based on fully digital processing, where each antenna element in the massive array is equipped with an up/down-conversion chain. Unlike previous works, we present a suite of greedy algorithms using pu

Familial Risks of Heart Failure in Sweden

Hjärtsvikt betecknar ett syndrom som innebär att hjärtat har otillräcklig förmåga att försörja kroppen med blod. Detta kan antingen bero på att hjärtat inte kan fyllas med eller stöta ut tillräckligt med mängd blod. Patienter med hjärtsvikt har i allmänhet hög dödlighet, detta trots att stora framsteg har gjorts avseende behandlingen av hjärtsvikt, speciellt sedan 1980-talet. Femårsöverlevnaden föIntroduction: Despite major advances, the incidence rate and mortality of heart failure (HF) remains high, with a five-year survival of approximately 50%. At the time of inception of this thesis the familial risks of HF, including the aspects of mortality, were largely underdetermined. This thesis is composed of four papers with the main aims as follows:To determine the risk of hospitalization of

Real-Time Implementation Aspects of Large Intelligent Surfaces

With the potential to provide a clean break from massive multiple-input multiple-output, large intelligent surfaces (LISs) have recently received a thrust of research interest. Various proposals have been made in the literature to define the exact functionality of LISs, ranging from fully active to largely passive solutions. Nevertheless, almost all studies in the literature investigate the fundam

Massive MIMO Asymptotics for Ray-Based Propagation Channels

Favorable propagation (FP) and channel hardening (CH) are desired properties in massive multiple-input multiple-output (MIMO) systems. To date, these properties have primarily been analyzed for classical statistical channel models, or ray-based models with very specific angular parameters and distributions. This paper presents a thorough mathematical analysis of the asymptotic system behavior for

Amputation-free survival in patients with diabetic foot ulcer and peripheral arterial disease : Endovascular versus open surgery in a propensity score adjusted analysis

Aims: The aim of the present study was to compare outcomes of endovascular surgery versus open vascular surgery in patients with diabetic foot ulcer (DFU) and peripheral arterial disease (PAD). Methods: Between 1984 and 2006, 1151 patients with DFU were admitted to the diabetic foot care team. Three hundred seventy-six patients with 408 limbs were consecutively included at a multidisciplinary foot

Leptin levels are associated with multiple sclerosis risk

Background: Obesity early in life has been linked to increased risk of developing multiple sclerosis (MS). Leptin and insulin are both associated with obesity, making them suitable candidates for investigating this connection. Objective: To determine if leptin and insulin are risk factors for relapsing–remitting multiple sclerosis (RRMS). Methods: In this nested case–control study using blood samp

Risk of major osteoporotic fracture after first, second and third fracture in Swedish women aged 50 years and older

Background: Osteoporosis affects approximately one in five European women and leads to fragility fractures, which result in poor health, social and economic consequences. Fragility fractures are a strong risk factor for subsequent major osteoporotic fracture (MOF), with risk of MOF being elevated in the 1–2 years following an earlier fracture, a concept described as “imminent risk”. This study exa

Hidradenitis Suppurativa in Sweden : A Registry-Based Cross-Sectional Study of 13,538 Patients

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition with nodules and fistula formation and scarring. It is a debilitating disease with a severe negative impact on quality of life. There is a need for increased knowledge about the social and lifestyle characteristics of patients with HS in general, and pregnant women in particular. Objectives: The aims of this study

Unravelling processing issues of nanowire-based solar cell arrays by use of electron beam induced current measurements

III-V vertical nanowire arrays have great potential for next generation photovoltaics. Development towards high performing nanowire solar cells, which consist of a parallel connection of millions of single nanowire solar cells, requires a fast characterization technique that establishes a link between device performance and device processing. In this work, we use electron beam induced current meas

Association between keratoconus disease severity and repeatability in measurements of parameters for the assessment of progressive disease

Background Progressive keratoconus can lead to severely impaired vision, but there is currently no consensus on the definition of progressive disease. Errors in the measurement of the parameters commonly used to establish progressive disease were evaluated in an attempt to determine the limits at which a true change in the values can be detected. The possible association between measurement error

Fighting “Gayropa” : Europeanization and Instrumentalization of LGBTI Rights in Ukrainian Public Debate

Against the backdrop of the conflict with Russia and growing approximation with the European Union (EU), the LGBTI movement in Ukraine seemed to have achieved some of its political goals, such as introducing changes in legislation and holding peaceful equality marches in Kyiv. At the same time, the last decade has seen a growing number of homophobic attacks by right-wing groups across the country,

Quantifying the regularity of a 3D set of points on the surface of an ellipsoidal object

Several natural and artificial structures, such as human skin and mammals cortices, exhibit a compound organization, with basic elements being distributed along a surface. The problem of quantifying the geometrical uniformity of this type of biological and physical compound structures is addressed in this work. This required the solution of several problems, including the detection, along the surf

Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing

Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenou

Spatial and temporal distribution patterns of Precambrian mafic dyke swarms in northern Mauritania (West African craton) : analysis and results from remote-sensing interpretation, geographical information systems (GIS), Google Earth ™ images, and regional geology

We used remote sensing, geographical information systems, Google Earth™ images, and regional geology in order to (i) improve the mapping of linear structures and understand the chronology of different mafic dyke swarms in the Ahmeyim area that belongs to the Archean Tasiast-Tijirit Terrane of the Reguibat Shield, West African craton, NW Mauritania. The spatial and temporal distributions with the t

A detailed description of the phenotypic spectrum of North Sea Progressive Myoclonus Epilepsy in a large cohort of seventeen patients

Introduction: In 2011, a homozygous mutation in GOSR2 (c.430G > T; p. Gly144Trp) was reported as a novel cause of Progressive Myoclonus Epilepsy (PME) with early-onset ataxia. Interestingly, the ancestors of patients originate from countries bound to the North Sea, hence the condition was termed North Sea PME (NSPME). Until now, only 20 patients have been reported in literature. Here, we provide a