The nematode Caenorhabditis elegans is a popular model system in genetics, not least because a majority of human disease genes are conserved in C. elegans. To generate a comprehensive inventory of its expressed proteome, we performed extensive shotgun proteomics and identified more than half of all predicted C. elegans proteins. This allowed us to confirm and extend genome annotations, characteriz

In budding yeast the cullin Rtt101 promotes replication fork progression through natural pause sites and areas of DNA damage, but its relevant subunits and molecular mechanism remain poorly understood. Here, we show that in budding yeast Mms1 and Mms22 are functional subunits of an Rtt101-based ubiquitin ligase that associates with the conjugating-enzyme Cdc34. Replication forks in mms1Delta, mms2

Methanol is an alternative fuel offering a lower well-to-wheel CO2 emission as well as a higher efficiency, given that the fuel is derived from biomass. In addition to reduced CO2, methanol does not emit soot particles when combusted which is a great advantage when attempting to reduce NOX levels due to the effectively non-existing NOX-soot trade-off. The engine setup used was a Scania D13 engine

Background: Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of the P-wave duration for development of AF. QRS vector magnitude has had a predictive value in ventricular arrhythmia development. We aimed to asses

Introduction This study follows cadmium and lead concentrations in blood in the adult population in northern Sweden over 24 years. Material and methods Concentrations of lead and cadmium were measured in single whole blood samples (B-Pb and B-Cd) from 619 men and 926 women participating in the Northern Sweden WHO MONICA Study on one occasion 1990–2014. Associations with smoking and dietary factors

BACKGROUND:: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicit

Despite the lack of scientific evidence for the effectiveness of Flexible Assertive Community Treatment (Flexible ACT), the model disseminates rapidly in the mental health services in a number of countries. This is in contrast to many evidence-based practices that often face comprehensive implementation barriers. Knowledge is needed on the dissemination of Flexible ACT to understand the relative s

Karlfeldtforskningen beskrivs, och vilka nya vägar kan den gå. Två föreslås: dels forskning om Karlfeldts positioner i den litterära offentligheten, dels forskning om Karlfeldts egendomliga bildspråk (Jean Paul, C F Dahlgren ) som är en del av en svensk tradition (Tegner, Tranströmer)

The 2014 Swedish National infrastructure plan allocated funds to implement a “Regional Superbus concept”. The concept involves the upgrading a number of existing regional express bus services to make them function as an alternative to investing in regional rail. The Regional superbus concept is an attempt to adapt the BRT planning philosophy to the regional scale and the context of the region it s

This paper examines the effect of competition on a firm's choice of opening hours in the motor vehicle inspection market. Competition affects the incentive inspection firms face when choosing opening hours, which influences the probability that consumers find service time that best matches their preferred time. We use 2SLS analyses to resolve the potential endogeneity of market entry decisions. Us

For life time estimation, it is desirable to capture the lowering of yield strength and premature failure that some alloys exhibits when subjected to hydrogen. For this, a mechanism based material model has been developed to simulate the hydrogen enhanced localized plasticity (HELP) for the superalloy IN718. The model accounts for the increase in mobility of moving dislocations during plastic defo

During the Early and Mid-Holocene significant changes in the ecology and socio-cultural spheres occurred around the Baltic Sea. Because of the underlying climatic changes and thus environmental alterations, the area was the scene for various cultural developments during the period under investigation. In the course of the melting of the glaciers at the end of the last Ice Age, isostatic and eustat

Aims: To evaluate hope in hepatitis C patients 9 years after curative treatment with pegylated interferon and ribavirin. Background: Successful treatment of hepatitis C leads to improved quality of life in responders compared with non-responders. The long-term effect of successful treatment on hope in these patients is not known. Design: Cross-sectional follow-up study of patients who displayed a

Little is known about the effectiveness of a psychosocial behaviour management programme on home-dwelling people with dementia. We developed a Behaviour Analytics & Support Enhancement (BASE) programme for care managers and professional caregivers of home care services in Japan. We investigated the effects of BASE on challenging behaviour of home-dwelling people with dementia. Methods: A clust

Purposes: It has earlier been suggested that dietary supplementation with N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) could have beneficial effects on cardio- vascular system patients with type 1 diabetes mellitus (DM1). Whether the benefit also extends to coronary circulation has not been yet investigated.Methods: In a double-blind placebo controlled cross-over study, 33 children with DM1 duratio

INTRODUCTION: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans.METHODS: Cerebral blood flow and amyloid β ((18)F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of