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Atavism, layering and subversion: Understanding great social challenges of today through the lens of cultural contingents

Great social challenges of today no longer come one by one. What makes them great is their ever-greater entanglement in one other and across multiple levels, including landscapes, regimes and niches. To this background, a major challenge facing many countries today is how to successfully address issues of interlocking problems of unsustainability caused by cultural contingents. We argue that while

Parents who have received ‘psycho-prophylaxis training’ during pregnancy and their experience of childbirth - An interview study highlighting the experiences of both parents

Background: The form of parental support during pregnancy is constantly changing due to developments in society. ‘Psycho-prophylaxis training’ is a form of parental support used in preparation for childbirth. Only a few studies describe the childbirth experience of both the parents. The aim was to interview parents receiving ‘psycho-prophylaxis training’ during pregnancy and to elucidate their exp

A societal history of potato knowledge in Sweden c. 1650–1800

This article concerns the societal history of potato knowledge in early modern Sweden. Focusing on the communication process, it analyses when, how, why, and which type of knowledge of the potato was communicated and ultimately experienced a societal breakthrough in early modern Sweden. The article shows that knowledge of the potato was transformed as it crossed social, spatial, and media boundari

Persons and Genes. Is a Gene-Centered Evolutionary Psychology Compatible with a Person-Oriented Approach to Psychological Science?

According to Zagaria et al. (2020), evolutionary psychology may be the meta-theory that is needed if psychological science is to enter a paradigmatic stage. Other writers have suggested that what is needed is a person-oriented approach, which focuses on the person as a complex system that needs to be studied (1) as a whole (holism), (2) as an intentional agent in interaction with its environment (

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for cardiovascular disease. Lp(a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipoprotein (LDL). Many of apo(a)'s potential pathological properties, such as inhibition of plasmin generation, have been attributed to its main structural domains, the kringl

Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX

Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX-inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IXSV; the catalytic domain with six surface amin