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Screening of the ryanodine 1 gene for malignant hyperthermia causative mutations by high resolution melt curve analysis.
A diagnosis of malignant hyperthermia (MH) can be determined by performing an in vitro (muscle) contracture test (IVCT) or by identifying a known MH causative mutation in the ryanodine receptor 1 gene (RYR1). Genetic diagnosis has an advantage over IVCT because it is less invasive. Direct sequencing of the very large RYR1 coding region (15.117 bases) is a laborious and expensive task. In this stud
Monte Carlo calculations of absorbed doses in tumours using a modified MOBY mouse phantom for pre-clinical dosimetry studies.
Abstract Background. Clinical treatment with radionuclides is usually preceded by biokinetic and dosimetry studies in small animals. Evaluation of the therapeutic efficacy is essential and must rely on accurate dosimetry, which in turn must be based on a realistic geometrical model that properly describes the transport of radiation. It is also important to include the source distribution in the do
Subjective Outcomes after Knee Arthroplasty
Outcome questionnaires are increasingly being established as a validated mode of acquiring unbiased information on the results after health interventions. Using an assortment of questionnaires, distributed by mail to 27 372 and to a subgroup of 3 600 patients on file in the Swedish Knee Arthroplasty register (SKAR), relevant questionnaires were found to represent a feasable means of acquiring info
Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.
The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platele
Elaboration of Argument in 1 Corinthians 15:20-34
The Experience of Occupational Deprivation in an Asylum Centre: The Narratives of Three Men
This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews explored the participants’ occupational history and its influence on their occupations in the asylum
A geographical and temporal high resolution emission data base for dispersion modelling of environmental NOx in Southern sweden
The Use of the Purchasing Power Parity Theory as a Normative Base in Measuring and Reporting Exchange Gains and Losses
Impact of climate change and variability on local-scale land use, Shaanxi, China.
Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies.
Please cite this paper as: Källén B, Finnström O, Lindam A, Nilsson E, Nygren K-G, Otterblad Olausson P. Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG 2010; Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born aft
Development and evaluation of a pharmacokinetic model for prediction of radioimmunotherapy based on pretherapy data.
The aim of this work was to develop a pharmacokinetic model for the analysis of the pharmacokinetics of (111)Inlabeled monoclonal antibodies (mAbs) in B-cell lymphoma patients and to evaluate the model's ability to predict a subsequent radioimmunotherapy by (90)Y-labeled mAbs. Data from quantified scintillation camera images and blood samples were used to fit a compartment model. The modeling incl
Results of a Fifteen-Year Follow-up Program in Patients Operated with Unilateral Neck Exploration for Primary Hyperparathyroidism.
Since the introduction of unilateral parathyroidectomy for primary hyperparathyroidism (pHPT) it has been debated wherever this approach is associated with greater long-term risk for recurrence compared to bilateral neck exploration.
Recension av Johnny Hagberg (red.): Haquin Spegel - En antologi
Testing for unit roots in panel data using wavelet ratio method
Macromolecular Drug Delivery: Basic Principles and Therapeutic Applications.
Macromolecular drugs hold great promise as novel therapeutics of several major disorders, such as cancer and cardiovascular disease. However, their use is limited by lack of efficient, safe, and specific delivery strategies. Successful development of such strategies requires interdisciplinary collaborations involving researchers with expertise on e.g., polymer chemistry, cell biology, nano technol