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Common variants in genes regulating free fatty acid metabolism and risk of type 2 diabetes and cardiovascular disease

Popular Abstract in Swedish Populärvetenskaplig sammanfattning (Summary in Swedish) Syftet med de studier som ligger till grund för denna avhandling är att klarlägga den genetiska och metabola bakgrunden till typ 2 diabetes (åldersdiabetes) och dess komplikationer. Typ 2 diabetes ökar mycket snabbt i Sverige och i världen och många forskare talar om en världsomfattande diabetesepidemi. Detta är aAbstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor

Key aspects of free and open source enterprise resource planning systems

This chapter introduces basic differences between Free/Open Source Enterprise Resources Planning systems (FOS-ERP) and Proprietary ERP (P-ERP), revisiting the previous work of Carvalho (2008). Taking into account that some years has passed and the economic downturn came, it updates key aspects of FOS-ERP under both vendor and adopter perspectives. Like its predecessor, this chapter contributes to

Neuroprotective and regenerative actions of GDNF and neurturin on nigral dopamine neurons in rat models of Parkinson’s disease – Prospects for clinical use of neurotrophic factors in neurodegenerative disorders

Popular Abstract in Swedish Tillväxtfaktorer kan förbättra cellöverlevnad och funktion i djurmodeller av Parkinson’s sjukdom. En av de vanligaste sjukdomarna i nervsystemet är Parkinson’s sjukdom. Den uppkommer genom att man gradvis förlorar en viss grupp av nervceller som använder signalsubstansen dopamin, vilket i sin tur leder till brist på dopamin i målområdet i hjärnan, striatum. Detta resulParkinson’s disease is characterized by progressive degeneration of the nigrostriatal dopamine system, which results in tremor, rigidity, akinesia and postural abnormalities. New therapeutic strategies are aimed at halting the neurodegenerative process or restoring the system by transplantation of fetal dopamine neurons. We have investigated the potential of the neurotrophic factors glial cell lin

Ellipsometry studies of liquid interfaces: New methodology and applications

Adsorption of several surface active agents, such as nonionics, diblock copolymers, triblock copolymers, proteins and phospholipids at the oil/water and air/water has been studied. In order to be able to do this, a new ellipsometry setup, which utilizes light guides, was developed and tested. A new evaluation methodology was developed and tested as well. This methodology is based on performing ea

Barriers for Energy Crops in Poland from the Farmers Perspective

With the recent expansions of the European Union, there are now 12 new member states that are implementing European policy. One of these policies, with implications for energy production and security, is the Common Agricultural Policy. This article will focus on the impact the Common Agricultural Policy can have on farmers in Poland who have been encouraged by calls to cultivate energy crops. In a

Expression and Regulation of Neuropeptide Y (NPY) in the Islets of Langerhans

Popular Abstract in Swedish Bukspottkörteln består av exokrin och endokrin vävnad. Den exokrina vävnaden utsöndrar en bukspottsaft rik på enzymer som hjälper till att bryta ner vår föda i mindre beståndsdelar. Den endokrina vävnaden insöndrar hormoner som hjälper till att reglera sockernivåerna i blodet. Det främsta hormonet som reglerar blodsockret är insulin, som bildas och insöndras från insuliThis thesis deals with the expression, localization and regulation of neuropeptide Y (NPY) in the pancreatic islets of Langerhans under normal and experimental conditions. NPY is widely distributed in the mammalian nervous system and belongs to a family of closely related petides also comprising peptide YY (PYY) and pancreatic polypeptide (PP). NPY exerts a variety of biological effects, such as s

The interplay between atmosphere, hydrology and land use by environmental modelling

Interactions between land surface and atmosphere induced by human activities and natural environmental dynamics act on a time scale that varies from seconds to millions of years. It is by exchanging heat, water, energy and carbon that land surface and atmospheric processes are closely interrelated and influence each other in reciprocal ways. Among the natural interactions between land surface and

Omvändelseromanen i svensk 1900-talslitteratur : några genrereflexioner

The Novel of Conversion in Swedish Twentieth-Century Literature: Some reflections on genre The point of departure for this article is an ongoing investigation of the novel of conversion in Swedish twentieth-century literature. After discussion of an appropriate definition of the genre, its origin is located to the spiritual autobiography in the tradition of Augustine's Confessions. A number of qui