BACKGROUND AND OBJECTIVES: Several pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals. METHODS: The contribution of amyloid and tau pathology was assessed through

Soft-x-ray holography which utilizes an optics mask fabricated in direct contact with the sample, is a widely applied x-ray microscopy method, in particular, for investigating magnetic samples. The optics mask splits the x-ray beam into a reference wave and a wave to illuminate the sample. The reconstruction quality in such a Fourier-transform holography experiment depends primarily on the charact

Objective. To review the currently available data on beam quality correction factors, kQ, for ionization chambers in clinical proton beams and derive their current best estimates for the updated recommendations of the IAEA TRS-398 Code of Practice. Approach. The reviewed data come from 20 publications from which kQ values can be derived either directly from calorimeter measurements, indirectly fro

Today, Sweden has one of the highest female labour force participation rates in the developed world, but how deep are the roots of women’s involvement in gainful employment? In this article, I present new estimates of women’s labour force participation rate between 1870 and 1960, the time when the country shifted from a predominantly agrarian economy to an industrial and services-based society. Th

An account for three production nodes for immigrant film workers in Sweden, Kaleidoscope, Tensta Filmförening and Cineco, as well as an analysis of some of their films.The subtitle of this essay echoes the title of David E. James’s book The Most Typical Avant-Garde, which makes the claim that the various minor cinemas of Los Angeles (amateur, immigrant, artists’ etc.) constitute the most distinctive avant-garde “on behalf of cultural practices that are commonly supposed not to even have existed”. The heterogeneous Swedish avant-garde scene has definitely been co

Models of coupled oscillator networks play an important role in describing collective synchronization dynamics in biological and technological systems. The Kuramoto model describes oscillator's phase evolution and explains the transition from incoherent to coherent oscillations under simplifying assumptions, including all-to-all coupling with uniform strength. Real world networks, however, often d

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Syftet med projekt, AirBeeSafe, var att öka kunskapen om bin och andra pollinerande insekters exponering för olika växtskyddsmedel i odlingslandskapet. Projektet utfördes i ett samarbete mellan SLU Centrum för kemiska bekämpningsmedel i miljön (CKB) och Biologiska institutionen, Lunds universitet, samt lantbrukare och biodlare. Finansiering gavs av Naturvårdsverket och det strategiska forskningsom

Computer vision/deep learning-based 3D human pose estimation methods aim to localize human joints from images and videos. Pose representation is normally limited to 3D joint positional/translational degrees of freedom (3DOFs), however, a further three rotational DOFs (6DOFs) are required for many potential biomechanical applications. Positional DOFs are insufficient to analytically solve for joint

Purpose/Objective(s): Over 30% of advanced prostate cancers harbor a predominance of neuroendocrine prostate cancer (NEPC) differentiation. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has numerous limitations in prostate adenocarcinoma (PCa-adeno), however there is no data that exists outside of isolated single person case reports to assess the utility of PET to restage and monitor

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. This review aims:. To assess the benefits and harms of regular physical activity interventions in adult kidney transplant recipients when compared with any other or no intervention. To determine whether benefits and harms vary in absolute or relative terms dependent on specific characteristics of t

Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A

Det övergripande syftet med denna avhandling är att främja den konceptuella förståelsen av transformativ innovationspolitik genom empirisk forskning med fokus på omställningen till en cirkulär ekonomi i den danska avfallssektorn. Under detta breda syfte handlar avhandlingen mer specifikt om att utforska frågor relaterade till geografi i transformativ innovationspolitik samt såkallad övergångsdynamThe overall aim of this thesis is to advance the conceptual understanding of transformative innovation policy through empirical research focusing on the transition towards a circular economy in the Danish waste sector. Under this broad aim, the thesis is more specifically concerned with exploring issues relating to the geography of transformative innovation policy as well as transition dynamics an

Global megacities are rapidly transforming through slum redevelopment and alternative resettlements of evicted poor. Resettlement is broadly seen as enabling, a basis of improved housing and even a pathway towards urban citizenship. This article offers an alternative perspective on urban resettlement, whereby the urban poor are subjected to life-threatening housing interventions. It builds on Mbem

Background: Evidence is increasing for the use of faecal immunochemical tests (FITs) for occult blood as diagnostic tools when colorectal cancer can be suspected. FITs have been used for this purpose in Swedish primary care since around 2005 despite absence of supporting guidelines. To our knowledge, the extent of this use has not been studied. Objective: To investigate the use of FITs as diagnost

The labor market is strongly gender segregated with few women working in the tech sector (e.g. IT) and few men working in the care sector (e.g. nursing). We tested the hypothesis that middle school students strongly associate technology with men and caregiving with women, and that this relates to girls’ lower interest in tech-focused educations. We measured technology/caregiving gender stereotypes

För att se om antalet D-interaktioner kunde minskas skickades information om interaktioner på individnivå till vårdcentraler.Allmänläkarna ombads att utifrån medföljande rekommendationer ompröva behandlingen och besvara en enkät.Mindre än hälften av D-interaktionerna berodde på medvetna ordinationsval.Mer än hälften av interaktionerna hade uppkommit det senaste året, trots tydlig varning vid ordinDuring 2012, one Swedish national goal for better health for elderly was to decrease drug-drug interactions. We performed an intervention, where the physicians in primary health care were alerted to which of their patients had a drug-drug interaction. The physicians received a letter with patient information and recommendations on how to act. They were requested to review if the interactions still

Background: A consistent imaging biomarker to standardize the evaluation of change in bone scan is an unmet need for patients (pts) with bone metastasis. BSI is quantitative interpretation of bone scan in pts with metastatic prostate cancer (mPCa). Here we have performed analytical and clinical studies to evaluate the change in computer automated BSI as a consistent imaging biomarker in pts with m

Background: Enzalutamide (ENZ), an androgen receptor antagonist therapy, was approved for patients (pts) with mCRPC. However, in standard of care for mCRPC pts, change in prostate specific antigen (PSA) is not accepted as an efficacy response measurement and the radiological change is inadequately measured in an interpreter-dependent subjective analysis of bone scan. Therefore, an objective effica