The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC protein in a cohort of 251 MCL patients complemented by analyses of structural aberrations and mRNA, in a sub-cohort of patients. Fourteen percent

Denna studie syftar till att undersöka de sociologiska implikationerna som existerar kring Human Resources (HR) användning av Artificiell Intelligens (AI)-verktyg inom rekryteringsarbete. Studien har ett sociologiskt fokus i form av de teorier som appliceras på analysen av studiens resultat. Dessa teoretiska ramverk är institutionell teori, som används för att förklara hur organisatoriska trender The aim of this essay is to examine the implications that Human Resources (HR) usage of Artificiall Intelligence (AI) in recruiting processes have in relation to a sociological theoretical framework. The aim is to highlight both positive and negative aspects of this and discuss these factors in relation to sociological institutional theory as well as theory of symbolic interactionism. The topic of

Party responsiveness to public opinion is a key question in the study ofdemocratic representation. While numerous studies have examined partyresponsiveness on broad ideological dimensions, there is less comparativeresearch on when and how parties respond to public opinion on morespecific issue dimensions. We aim to address this research gap by studyingparty positional responsiveness on seven issue

Aim: This position paper focuses on healthy ageing for the frailest and institutionalized older adults in the context of the recent pandemic. The paper aims to identify and discuss hindering and promoting factors for healthy ageing in this context, taking both health safety and a meaningful social life into account, in a pandemic situation and beyond. Background: The recent COVID-19 pandemic has h

Context. Stellar tidal streams are a key tracer of galaxy evolution and have the potential to provide an indirect means for tracing dark matter. For the Local Group, many diffuse substructures have been identified and their link to galaxy evolution has been traced. However, the Local Group does not offer a statistically significant sample of stellar tidal streams. Thus, an analysis of a larger sam

A novel pretreatment approach was developed in the present study to simultaneously reduce the content of inorganic troubling elements (TEs) and improve biomass energy density, i.e., combined leaching and steam explosion (SE) pretreatment with mechanical pressing. Three different high-ash-containing biomass feedstocks were studied – wheat straw (WS), spruce bark (SB), and empty fruit bunches of oil

Bakgrund: Ambulanspersonal och akutvårdssjuksköterskor arbetar under pressande förhållanden, där de ofta utsätts för stressfaktorer som dödsfall, våld och traumatiska händelser. Studier visar att en stor del av ambulanspersonalen anser att deras arbete är psykiskt påfrestande, och problem som akut och kronisk stress, sömnsvårigheter och PTSD är vanliga bland dem. Det har blivit tydligt att detta a

This thesis explores the algorithmic imaginaries and practices of the momo community, a spontaneously formed anonymous group on the Chinese social media platform RED. By adopting a cultural perspective on algorithms, this study investigates how momo users conceptualize algorithms, their practices influenced by these conceptualizations, and how these practices manifest as a form of algorithmic resi

The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important role and thus has been proposed as a therapeutic target for modulation of the neuroinflammatory processes in PD. In this regard, dominant-negative TNF (DN-TNF) ag

RATIONALE: Preterm infants diagnosed with bronchopulmonary dysplasia (BPD) are thought to have fewer and larger alveoli than their term peers, but it is unclear to what degree this persists later in life.OBJECTIVES: To investigate to what degree the distal airspaces are enlarged in adolescents born preterm and to evaluate the new Airspace Dimension Assessment (AiDA) method in investigating this gr

Eye tracking technology has become increasingly prevalent in scientific research, offering unique insights into oculomotor and cognitive processes. The present article explores the relationship between scientific theory, the research question, and the use of eye-tracking technology. It aims to guide readers in determining if eye tracking is suitable for their studies and how to formulate relevant

Research topic/aim:The digitalization of education is a prioritized field for governments and policymakers all over the world, not least in the Nordic countries. The educational sector is expected to play an important role in the digitalization of society and in fostering digital citizens, and to harness the potential of technology for improving its own practices (ITU, UNESCO & Unicef, 2020).

Over the past two decades there has been increased interest in orphan drug development for rare diseases. However, hurdles to clinical trial design for these disorders remain. This phase 1a/1b study addressed several challenges, while evaluating the safety and tolerability of the novel oral molecule KL1333 in healthy volunteers and subjects with primary mitochondrial disease.KL1333 aims to normali

Background: Elevated filling pressure is a hallmark of heart failure (HF) and portends poor prognosis. Accurate diagnosis is challenging, given that patients with normal filling pressure at rest develop disproportionate elevation with sudden preload increase. We aimed to test the accuracy of the ratio between mitral inflow velocity (E) and left ventricular stroke volume (SV) to identify patients w

Multiple myeloma is a heterogeneous hematological disease that originates from the bone marrow and is characterized by the monoclonal expansion of malignant plasma cells. Despite novel therapies, multiple myeloma remains clinically challenging. A common feature among patients with poor prognosis is the increased activity of the epigenetic silencer EZH2, which is the catalytic subunit of the PRC2.

Background: Calcitonin gene-related peptide (CGRP) is part of the calcitonin peptide family, which includes calcitonin (CT), amylin (AMY), and adrenomedullin (ADM). CGRP and its receptor are highly present in the trigeminovascular system (TVS). Recent research suggests that other members of the calcitonin family could be feasible therapeutic targets in the treatment of migraine. The present study