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Brain organoid technology has transformed both basic and applied biomedical research and paved the way for novel insights into developmental processes and disease states of the human brain. While the use of brain organoids has been rapidly growing in the past decade, the accompanying bioengineering and biofabrication solutions have remained scarce. As a result, most brain organoid protocols still
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
The Grande de Tárcoles River in Costa Rica is one of the most polluted and degraded river basins in Central America. At the same time Costa Rica is a country internationally recognized for progressive environmental management. At least on paper, the country fosters sustainable river management in the form of integrated water resources management (IWRM). In the specific case of the Grande de Tárcol
Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness. The general pattern across most taxa is that after birth telomere length gradually decreases with age. Telomere protection and restoration mechanisms are usually assumed to reduce the rate of shortening or at most keep telomere length const
INTRODUCTION: Cranial computed tomography (CT) is an affordable and widely available imaging modality that is used to assess structural abnormalities, but not to quantify neurodegeneration. Previously we developed a deep-learning–based model that produced accurate and robust cranial CT tissue classification. MATERIALS AND METHODS: We analyzed 917 CT and 744 magnetic resonance (MR) scans from the G
Automated fault diagnosis can facilitate diagnostics assistance, speedier troubleshooting, and better-organised logistics. Currently, most AI-based prognostics and health management in the automotive industry ignore textual descriptions of the experienced problems or symptoms. With this study, however, we propose an ML-assisted workflow for automotive fault nowcasting that improves on current indu
Parkinson's disease (PD) is an age-related chronic neurological disorder, mainly characterized by the pathological feature of α-synuclein (α-syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of PD, synaptic dysfunction, including dysregulation of axonal transport, impaired exocytosis, and endocytosis are identified as crucial events of PD pathogenesis.
To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population. GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black European
Introduction: Carbon monoxide (CO) is a colorless and odorless gas that is a leading cause of environmental poisoning in the USA with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and leukocyte sequestration in brain microvessel segments leading to increased reactive oxygen species. Another important pathway is the effects of CO o
Background: Adverse childhood experiences (ACE) can have negative effects on cognitive, social and emotion regulation abilities, which can threaten the child’s school integration and capacity to learn. While steady relations to sensitive, understanding adults may moderate these negative outcomes, the difficulties of children with ACEs pose a major challenge for teachers, whose insufficient prepara
Asymmetry. What is in the word? One kind of asymmetry is asymmetrical coaction, that is, when actors relate in different ways to one another and/or partake differently in an action done together. Coaction requires that the actors acting together, during the process, reach an enlarged mentality (Arendt, Lectures on Kant’s Political Philosophy), either through putting themselves in the position of o
The subfamily Nossidiinae was established in 2019 and is comprised of five genera including one fossil genus. Among them, Nossidium Erichson and Sindosium Johnson share many morphological similarities. To this point, two extant Nossidium-species, N. flachi Ganglbauer and N. pilosellum (Marsham) have been recorded in the Palaearctic realm. In this paper, we describe three new species, Nossidium kor
Carbon materials with unique sp2-hybridization are extensively researched for catalytic applications due to their excellent conductivity and tunable physicochemical properties. However, the development of economic approaches to tailoring carbon materials into desired morphologies remains a challenge. Herein, a convenient “bottom-up” strategy by pyrolysis of graphitic carbon nitride (g-C3N4) (or ot
In the 1920s and 30s, a criminal investigation followed by a trial against a group of allegedly homosexual men was launched in Gothenburg, Sweden. Almost a century later, Swedish artist Conny Karlsson Lundgren engages with these events in a multifaceted two-part installation and performative work that borrows the title from the investigation, The Gothenburg Affair (Göteborgsaffären). In this artic
This paper addresses the comorbidity of substance use and mental illness among women in Iran and the barriers they encounter in accessing treatment. Research has demonstrated a higher prevalence of comorbidity of substance use disorders and mental illness among women than men. It has been suggested that women in Iran may face numerous barriers to appropriate care, such as stigma and discrimination
In healthcare, data privacy of patients regulations prohibits data from being moved outside the hospital, preventing international medical datasets from being centralized for AI training. Federated learning (FL) is a data privacy-focused method that trains a global model by aggregating local models from hospitals. Existing FL techniques adopt a central server-based network topology, where the serv
Has Visual International Relations (IR) become too distant from the content of visual artefacts? This is a paradoxical question. Visual IR is a vibrant and pluralist field exploring visuals in innumerable ways. Nonetheless, the field tends to focus on 'deep' readings of the socio-political implications of visual artefacts at the expense of a close and attentive observation and description of the e
