Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant t

OBJECTIVE: To determine factors associated with outcomes following pelvic exenteration for advanced nonrectal pelvic malignancy.BACKGROUND: The PelvEx Collaborative provides large volume data from specialist centers to ascertain factors associated with improved outcomes.METHODS: Consecutive patients who underwent pelvic exenteration for nonrectal pelvic malignancy between 2006 and 2017 were identi

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors

Surgical treatment of Hirschsprung's disease commonly involves resection of the aganglionic segment of the colon and endorectal pull-through. Postoperative complications include anastomotic leakage and/or stricture, both believed to be caused by inadequate perfusion of the mobilized bowel or high tension in the anastomosis, but this has never been investigated. In this case, laser speckle contrast

As antiretroviral therapies have transformed HIV into a manageable chronic disease, many individuals have or will choose to have children, and the use of assisted reproductive technology can serve as an effective risk-reducing strategy. In this thematic literature review, we examine the state of research on access to and availability of assisted reproductive health technologies for people living w

Much has been written about how Christianity is used, instrumentalised or even hijacked by various right-wing populist movements in contemporary Europe. This is true in a certain way. At the same time it can be argued that there are many figures of thought within Christian theology that easily go together with populist discourses. This has three consequences, or so it is argued in this article. Fi

The recent diffusion of new formats of archaeological publication systems results from ad hoc solutions conceived and realized for serving specific communication needs. These new formats are customized for facilitating the fruition of specific archaeological information and can be tailored and structured for hosting datasets and results. Unlike standard publications, they do not represent the fina

The bark beetle Ips typographus carries numerous fungi that could be assisting the beetle in colonizing live Norway spruce (Picea abies) trees. Phenolic defenses in spruce phloem are degraded by the beetle's major tree-killing fungus Endoconidiophora polonica, but it is unknown if other beetle associates can also catabolize these compounds. We compared the ability of five fungi commonly associated

Evaluation of two rulings of the Court of Justice of the European Union (CJEU) in C-753/18 STIM and SAMI v Fleetmanager and Nordisk Biluthyrning and in C-637/19 BY v CX, both concerning the notion of 'communication to the public' present in Article 3 InfoSoc Directive 2001/29.

Evaluation of Article 17(7) and (9) Directive 2019/790 on copyright in the Digital Single Market (DSM Directive) establishing an interface between the obligations of online content-sharing service providers in Article 17(1)-(4) DSM Directive, and the European system of limitations in Article 5 Directive 2001/29 (InfoSoc Directive). Part I, published on the Kluwer Copyright Blog.

Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. A

Background: The scapular osseous free flap (SOFF) has become an important reconstructive option for complex head and neck defects. Postoperative donor site function is, however, an important consideration. The objective of this study was to prospectively investigate SOFF donor site morbidity and to relate the findings to hand dominance and neck dissection. Methods: Objective assessment included bi

Background: Multiple risk scores claim to predict the probability of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. It is unclear which scores have undergone external validation and are the most accurate. The aim of this study was to identify risk scores for POPF, and assess the clinical validity of these scores. Methods: Areas under receiving operator characteristic curve (A

Magnetomotive ultrasound is an emerging technique that enables detection of magnetic nanoparticles. This has implications for ultrasound molecular imaging, and potentially addresses clinical needs regarding determination of metastatic infiltration of the lymphatic system. Contrast is achieved by a time-varying magnetic field that sets nanoparticle-laden regions in motion. This motion is governed b