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Bridging technique failure through low-tech improvisation: A case study of food microbiology
Modern technology for food safety studies includes standardized protocols and equipment. However, appropriate technology needs to step in to bridge technology dys- or malfunctioning. We examined different low-tech methods for extraction of bacteria from fresh vegetables. Standard equipment including stomacher and filter bags were compared to extraction using bread stick and alternative filter mate
Development of a chemical probe against NUDT15
The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides, but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for leukemia and inflammatory diseases. Nonetheless, its physiological roles remain elusive. Here, we sought to develop small-molecule NUDT15 inhibitors
Assembly of Capsids from Hepatitis B Virus Core Protein Progresses through Highly Populated Intermediates in the Presence and Absence of RNA
The genetic material of viruses is protected by protein shells that are assembled from a large number of subunits in a process that is efficient and robust. Many of the mechanistic details underpinning efficient assembly of virus capsids are still unknown. The assembly mechanism of hepatitis B capsids has been intensively researched using a truncated core protein lacking the C-terminal domain resp
Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy
BACKGROUND: Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. Autophagy dysfunction and protein aggregation in AD may be involved in a vicious circle. The aim of this study was to investigate whether tau or amyloid beta
Towards a stage model of regional industrial path transformation
The recent debate on innovation-based structural change in Evolutionary Economic Geography is characterised by a strong focus on the rise of new industrial paths. This paper seeks to shift attention and cast light on radical innovation activities occurring within existing paths without necessarily leading to their dissolution. Departing from a systemic perspective of path development we propose a
Text message-based lifestyle intervention in primary care patients with hypertension : a randomized controlled pilot trial
OBJECTIVE: To evaluate the feasibility of a randomized controlled pilot study with lifestyle-promoting text messages as a treatment for hypertension in primary care.DESIGN: Randomized controlled pilot trial.SETTING: Three primary health care centers in southern Sweden.SUBJECTS: Sixty patients aged 40-80 years with hypertension were included.MAIN OUTCOME MEASURES: Feasibility of the pilot study, i.
Mobility of near surface MOVPE grown InGaAs/InP quantum wells
In this work, we study the electron mobility of near surface metal organic vapor phase epitaxy-grown InGaAs quantum wells. We utilize Hall mobility measurements in conjunction with simulations to quantify the surface charge defect density. Buried quantum wells are limited by polar optical phonon scattering at room temperature. In contrast, the quantum wells directly at the surface are limited by r
Dual origin of pairing in nuclei
The pairing correlations of the nucleus 120Sn are calculated by solving the Nambu–Gor’kov equations, including medium polarization effects resulting from the interweaving of quasiparticles, spin and density vibrations, taking into account, within the framework of nuclear field theory (NFT), processes leading to self-energy and vertex corrections and to the induced pairing interaction. From these r
Unified description of structure and reactions : Implementing the nuclear field theory program
The modern theory of the atomic nucleus results from the merging of the liquid drop model of Niels Bohr and Fritz Kalckar, and of the shell model of Marie Goeppert Meyer and Hans Jensen. The first model contributed the concepts of collective excitations. The second, those of independent-particle motion. The unification of these apparently contradictory views in terms of the particle-vibration and
Interweaving of elementary modes of excitation in superfluid nuclei through particle-vibration coupling : Quantitative account of the variety of nuclear structure observables
A complete characterization of the structure of nuclei can be obtained by combining information arising from inelastic scattering, Coulomb excitation, and γ-decay, together with one- and two-particle transfer reactions. In this way it is possible to probe both the single-particle and collective components of the nuclear many-body wave function resulting from the coupling of these modes and, as a r
Separation of the 1+/1- parity doublet in 20Ne
The (J, T)=(1, 1) parity doublet in 20Ne at 11.26 MeV is a good candidate to study parity violation in nuclei. However, its energy splitting is known with insufficient accuracy for quantitative estimates of parity violating effects. To improve on this unsatisfactory situation, nuclear resonance fluorescence experiments using linearly and circularly polarized γ-ray beams were used to determine the
Testing two-nucleon transfer reaction mechanism with elementary modes of excitation in exotic nuclei
Nuclear Field Theory of structure and reactions is confronted with observations made on neutron halo dripline nuclei, resulting in the prediction of a novel (symbiotic) mode of nuclear excitation, and on the observation of the virtual effect of the halo phenomenon in the apparently non-halo nucleus 7Li. This effect is forced to become real by intervening the virtual process with an external (t,p)
Electron capture processes in intermediate mass stars
Intermediate mass stars develop a degenerate core constituted of O, Ne and Mg during their evolution. As the density in the core increases electron capture sets in igniting Ne and O burning. Particularly important is electron capture on 20Ne that has been found recently to be dominated by a second forbidden transition from the 0+ ground state of 20Ne to the 2+ ground state of 20F. We have performe
Nuclear field theory predictions for 11Li and 12Be : Shedding light on the origin of pairing in nuclei
Recent data resulting from studies of two-nucleon transfer reaction on 11Li, analyzed through a unified nuclear-structure-direct-reaction theory have provided strong direct as well as indirect confirmation, through the population of the first excited state of 9Li and of the observation of a strongly quenched ground state transition, of the prediction that phonon-mediated pairing interaction is the
Core polarization and neutron halos
The effects of core polarization on the structure of Li and Be halos and their consequences on one-and two-neutron transfer reactions are discussed.
Pairing Interaction and Two-Nucleon Transfer Reactions
Soon after the formulation of BCS theory [1], it was recognized by Bohr, Mottelson, and Pines that the existence of an energy gap in the intrinsic excitation spectrum of deformed nuclei displayed a suggestive analogy with that observed in the electronic spectra of metallic superconductors and could, like this one, be described at profit in terms of correlated pairs [2]. Their paper represented the
Medium polarization effects on the superuidity of finite nuclei and of the inner crust of neutron stars
We review recent progress made in understanding the role of medium polarization on superuidity in finite nuclei and in the inner crust of neutron stars. The interweaving of collective and quasiparticle degrees of freedom is treated within the framework of Nuclear Field Theory, propagating the basic renormalization processes through the Nambu-Gor’kov equations. It is then possible to obtain quantit
Coherence and the Successive Contribution in Two-Neutron Transfer reactions
In this short letter we briefly address two important points of two-neutron transfer reactions, namely the successive nature of the process and the role of pairing correlations during this sequential transfer. The discussion is made within the 2-step DWBA formalism. The calculations were carried out making use of software specifically developed for this purpose, which includes successive, simultan
Quantitative study of coherent pairing modes with two-neutron transfer : Sn isotopes
Pairing rotations and pairing vibrations are collective modes associated with a field, the pair field, which changes the number of particles by two. Consequently, they can be studied at profit with the help of two-particle transfer reactions in superfluid and in normal nuclei, respectively. The advent of exotic beams has opened, for the first time, the possibility to carry out such studies in medi