Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to reduce the regenerative capacity of aged HSCs. Such mechanisms do not however account for the change i

The northern terrestrial net ecosystem carbon balance (NECB) is contingent on inputs from vegetation gross primary productivity (GPP) to offset the ecosystem respiration (R-eco) of carbon dioxide (CO2) and methane (CH4) emissions, but an effective framework to monitor the regional Arctic NECB is lacking. We modified a terrestrial carbon flux (TCF) model developed for satellite remote sensing appli

This paper discusses a number of questions with regard to Sweden’s economic and political development: † How did Sweden become rich? † What explains Sweden’s high level of income equality? † What were the causes of Sweden’s problems from 1970 to 1995? † How is it possible that Sweden, since the crisis of the early 1990s, is growing faster than most EU countries despite its high taxes and generous

Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of on

Background. Autism spectrum disorder (ASD) is a neurodevelopmental disorder of complex etiology. Although strong evidence supports the causal role of genetic factors, environmental risk factors have also been implicated. This study used a co-twin-control design to investigate low birth weight as a risk factor for ASD. Method. We studied a population-based sample of 3715 same-sex twin pairs partici

The composition of milk fat from dairy cows is related to both genetic and environmental factors. Here, the effect of feed and herd was examined in 3 Scandinavian breeds, namely Danish Holstein-Friesian (DH), Danish Jersey (DJ), and Swedish Red (SR). In total, milk samples from 1,298 cows kept in indoor housing systems were collected from 61 conventional dairy herds in Denmark and Sweden. The fatt

New laminar burning velocity measurements of 85: 15% (by volume) H-2-CO and H-2-N-2 mixtures with O-2-He oxidizer are reported at lean conditions and elevated pressures (1-10 atm). Experiments are conducted using the heat flux method at initial temperature of 298 K. In this technique a near adiabatic flame is stabilized by balancing the heat loss from the flame to the burner with heat gain to the

Ancestral background, specifically African descent, confers higher risk for development of inhibitory antibodies to factor VIII (FVIII) in haemophilia A. It has been suggested that differences in the distribution of FVIII gene (F8) haplotypes, and mismatch between endogenous F8 haplotypes and those comprising products used for treatment could contribute to risk. Data from the Hemophilia Inhibitor

OBJECTIVE: P-selectin glycoprotein ligand-1 (PSGL-1) has been shown to play a significant role in septic lung injury. However, the detailed role of PSGL-1 in the pulmonary leukocyte recruitment remains elusive. We have developed a method based on intravital fluorescence microscopy of the lung microcirculation to examine the role of PSGL-1 in the extravasation process of leukocytes in septic lung d

In this report we explore the structural and optical properties of GaAs/AlGaAs heterostructure nanowires grown by metalorganic vapour phase epitaxy using gold seed-particles. The optical studies were done by low-temperature cathodoluminescence (CL) in a scanning electron microscope (SEM). We perform a systematic investigation of how the nanowire growth-temperature affects the total photon emission

Recent discussions of method in historical Jesus research have called into question the use of criteria for evaluating the authenticity of Gospel material. The present article lays out the reasons why a number of scholars call for an abandonment of the so-called criteria approach and then criticizes the allegation that this approach is genetically and logically dependent on form criticism. By anal

Precise geochronology, combined with paleomagnetism on mafic intrusions, provides first-order information for paleoreconstruction of crustal blocks, revealing the history of supercontinental formation and break-up. These techniques are used here to further constrain the apparent polar wander path of the Kaapvaal Craton across the Neoarchean-Paleoproterozoic boundary. U-Pb baddeleyite ages of 2441

Abstract Global change and GHG emission modelling are dependent on accurate wetness estimations for predictions of e.g. methane emissions. This study aims to quantify how the slope, drainage area and the TWI vary with the resolution of DEMs for a flat peatland area. Six DEMs with spatial resolutions from 0.5 to 90 m were interpolated with four different search radiuses. The relationship between ac

Diabetes mellitus is the main reason for visual impairment among patients of working ages. The aim of this paper was to investigate the prognosis of eye complications in patients with diabetes during 10 years of follow-up and contributing risk factors. Data from ophthalmological records (occurrence of retinopathy and laser treatment and visual acuity), and clinical data (blood pressure, glycosylat

Using firm-level data collected through a survey in 2008 followed by semi-structured interviews with firms in 2009-2010, this article systematically compares the geography of linkages of the software industry between two regions, one in India (Pune) and one in China (Great Beijing). In contrast to what the literature on knowledge bases and regional innovation systems argues the paper points out to

Accumulation of amyloid-beta (A beta), believed to be a key trigger of Alzheimer disease (AD), could result from impaired clearance mechanisms. Previously, we showed that the cysteine protease cathepsin B (CatB) degrades A beta, most likely by C-terminal truncation, in mice expressing human amyloid precursor protein with familial AD-linked mutations (hAPP(FAD)). In addition, the A beta-degrading a

The objective was to estimate the cost-effectiveness of TNF-inhibitors for the treatment of rheumatoid arthritis in Swedish clinical practice, both as a first and second biological treatment, with or without the combination of conventional DMARDs. Further sub-group analysis of etanercept treatment was performed. Patient level data were obtained from three regions of the Swedish Rheumatology Regist

In the circuits of culture there are a multitude of representations in circulation. These representations are derived from a range of media products such as guidebooks and tourist brochures. Furthermore, these media products and representations continuously converge with each other. The question, then, is what representations are contained within these converged media products. This article theref

Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The