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Assembly of RNA nanostructures on supported lipid bilayers.

The assembly of nucleic acid nanostructures with controlled size and shape has large impact in the fields of nanotechnology, nanomedicine and synthetic biology. The directed arrangement of nano-structures at interfaces is important for many applications. In spite of this, the use of laterally mobile lipid bilayers to control RNA three-dimensional nanostructure formation on surfaces remains largely

Convective heat transfer and fluid flow physics in some ribbed ducts using liquid crystal thermography and PIV measuring techniques

Enhancement of forced convection is important in several engineering applications. Surface modifications like rib-roughening are commonly used in applications such as compact heat exchangers and internal cooling of gas turbine blades and vanes. This paper gives a brief summary of convective heat transfer and fluid flow in some ribbed ducts using liquid crystal thermography and PIV measuring techni

pK(a) Values for the Unfolded State under Native Conditions Explain the pH-Dependent Stability of PGB1.

Understanding the role of electrostatics in protein stability requires knowledge of these interactions in both the folded and unfolded states. Electrostatic interactions can be probed experimentally by characterizing ionization equilibria of titrating groups, parameterized as pK(a) values. However, pK(a) values of the unfolded state are rarely accessible under native conditions, where the unfolded

Dry deposition of reactive nitrogen to European ecosystems: a comparison of inferential models across the NitroEurope network

Inferential models have long been used to determine pollutant dry deposition to ecosystems from measurements of air concentrations and as part of national and regional atmospheric chemistry and transport models, and yet models still suffer very large uncertainties. An inferential network of 55 sites throughout Europe for atmospheric reactive nitrogen (N-r) was established in 2007, providing ambien

The Best Laid Plans: Using the Capability Approach to Assess Neoliberal Conservation in South Africa-The Case of the iSimangaliso Wetland Park

The article documents the case of South Africa's struggle to reconcile racially based poverty, a legacy of apartheid, and attempts to conserve the country's unique and important biodiversity. We present an analysis of KwaDapha, a small village in the iSimangaliso Wetland Park in northern KwaZulu-Natal, a protected area and UNESCO World Heritage Site, in terms of the capability approach. Despite So

Phenology and its role in carbon dioxide exchange processes in northern peatlands

Ecosystem phenology plays an important role in carbon exchange processes and can be derived from continuous records of carbon dioxide (CO2) exchange data. In this study we examined the potential use of phenological indices for characterizing cumulative annual CO2 exchange in four contrasting northern peatland ecosystems. We used the approach of Jonsson and Eklundh (2004) to derive a set of phenolo

An optical system for measuring nitric oxide using spectral separation techniques

An optical sensor based on differential absorption spectroscopy for real-time monitoring of industrial nitric oxide (NO) gas emission is described. The influence of gas absorption interference from sulfur dioxide (SO2) in the environment was considered and a spectral separation technique was developed in order to eliminate this interference effect. The absorption spectrum of SO2 around 226 nm was

Association of cognitive performance with the metabolic syndrome and with glycaemia in middle-aged and older European men: the European Male Ageing Study

Background and aims Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting. We investigated the association between metabolic syndrome and cognitive function in a population sample of middle-aged and older European men and whether any observed association could be explained by lifestyle or other confounding factors. Methods A total of 3369 me

Effects of changing exposure to neighbourhood greenness on general and mental health: A longitudinal study.

Green neighbourhood environments have been associated with physical and psychological wellbeing in adults. Access to greenness is potentially more important in vulnerable subgroups. In this study based on longitudinal survey data from southern Sweden the cohort was divided into prognostic groups for good self-reported general (n=8891) and mental (n=9444) health. We used independent survey data to

Protein Unfolding allow use of Commercial Antibodies in an Apolipoprotein M sandwich ELISA.

Apolipoprotein M (apoM) is a member of the lipocalin super family and circulates in plasma attached to high density lipoprotein particles. ApoM plays a role in cholesterol metabolism and has recently been identified as transporter for the signaling lipid Sphingosine-1-Phosphate (S1P) in plasma. S1P is implicated in several inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis.

Genomic and transcriptional alterations in lung adenocarcinoma in relation to smoking history.

Purpose Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of tobacco-related carcinogenesis, and its effect on the genomic and transcriptional landscape in lung cancer are not fully understood. Experimental Design 1398 (277 never-smokers, 1121 smokers) genomic and 1449 (370 never-smokers, 1079 smokers) transcriptional profiles were assembled from public lung

When the pond turtle followed the reindeer: effect of the last extreme global warming event on the timing of faunal change in Northern Europe

Faunal communities have been shaped in different ways by past climatic change. The impact of the termination of the last Glacial and the onset of the present (Holocene) Interglacial on large-scale faunal shifts, extinction dynamics and gene pools of species are of special interest in natural sciences. A general pattern of climate-triggered range expansion and local extinction of vertebrate species

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of Dementia with Lewy Bodies.

Clinical and neuropathological similarities between Dementia with Lewy Bodies (DLB), ParkinsonÕs and AlzheimerÕs diseases (PD and AD, respectively) suggest that these disorders may share etiology. To test this hypothesis we have performed an association study of 54 genomic regions, previously implicated in PD or AD, in a large cohort of DLB cases and controls. The cohort comprised 788 DLB cases an

Contrast and rate of light intensity decrease control directional swimming in the box jellyfish Tripedalia cystophora (Cnidaria, Cubomedusae)

Box jellyfish respond to visual stimuli by changing the dynamics and frequency of bell contractions. In this study, we determined how the contrast and the dimming time of a simple visual stimulus affected bell contraction dynamics in the box jellyfish Tripedalia cystophora. Animals were tethered in an experimental chamber where the vertical walls formed the light stimuli. Two neighbouring walls we

Body fat, abdominal fat and body fat distribution related to cardiovascular risk factors in pre-pubertal children.

Aim We analysed whether total body fat, abdominal fat and body fat distribution are associated with higher composite risk factor scores for cardiovascular disease (CVD) in young children. Methods Cross-sectional study of 238 children aged 8-11 years. Total body fat (TBF) and abdominal fat mass (AFM) were measured by DXA. TBF was expressed as a percentage of body weight (BF%). Body fat distribution