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Molecular phylogeny of Lymantriinae (Lepidoptera, Noctuoidea, Erebidae) inferred from eight gene regions

To understand the evolutionary history of Lymantriinae and test the present higher-level classification, we performed the first broad-scale molecular phylogenetic analysis of the subfamily, based on 154 exemplars representing all recognized tribes and drawn from all major biogeographical regions. We used two mitochondrial genes (cytochrome c oxidase subunit I and 16S ribosomal RNA) and six nuclear

Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development

There is a pressing need to address the current major gaps in epilepsy treatment, in particular drug-resistant epilepsy, antiepileptogenic therapies, and comorbidities. A major concern in the development of new therapies is that current preclinical testing is not sufficiently predictive for clinical efficacy. Methodologic limitations of current preclinical paradigms may partly account for this dis

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), s

An algebraic iterative reconstruction technique for differential X-ray phase-contrast computed tomography

Iterative reconstruction has a wide spectrum of proven advantages in the field of conventional X-ray absorption-based computed tomography (CT). In this paper, we report on an algebraic iterative reconstruction technique for grating-based differential phase-contrast CT (DPC-CT). Due to the differential nature of DPC-CT projections, a differential operator and a smoothing operator are added to the i

Mixed discriminatory judgments of individuals’ warmth and competence related abilities

Although several studies have demonstrated that stereotypes can be mixed in terms of warmth and competence (e.g., cold but competent), the possibility of mixed discrimination has received very little attention so far. To this end, the present study investigated mixed discriminatory judgments of individuals. In two studies, the participants judged the empathic (warmth) and the cognitive (competence

Numerical radiative transfer with state-of-the-art iterative methods made easy

This article presents an on-line tool and its accompanying software resources for the numerical solution of basic radiation transfer out of local thermodynamic equilibrium (LTE). State-of-the-art stationary iterative methods such as Accelerated Lambda-iteration and Gauss-Seidel schemes, using a short characteristics-based formal solver are used. We also comment on typical numerical experiments ass

Evaluation of prestress losses in nuclear reactor containments

The most critical safety barrier in a nuclear power plant, the concrete containment, is prestressed by hundreds of tendons, both horizontally and vertically. The main purpose of the containment is to prevent radioactive discharge to the environment in the case of a serious internal accident. Due to creep and shrinkage of concrete and relaxation of the prestressing steel, tendon forces decrease wit

Interplay of adsorbate-adsorbate and adsorbate-substrate interactions in self-assembled molecular surface nanostructures

The adsorption of 2,6-naphthalenedicarboxylic acid (NDCA) molecules on the Ag(110), Cu(110), and Ag(111) surfaces at room temperature has been studied by means of scanning tunnelling microscopy (STM). Further supporting results were obtained using X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS). On the Ag(110) support, which had an average terrace width of only

Framing shared services Accounting, control and overflows

During the last decade there has been an increase in the use of horizontal organizational relationships (HORs) such as strategic alliances, shared services, and outsourcing. Studies accentuate the unstable, fragile nature of HORS and the importance of directing attention to how these arrangements are formed and how and why they change. The aim in this study is to explore control problems of HORs a

Shell structure of weakly-bound and resonant neutrons

The systematic change of shell structure in both weakly bound and resonant neutron one-particle levels in nuclei towards the neutron drip line is exhibited, solving the coupled equations derived from the Schrodinger equation in coordinate space with the correct asymptotic behaviour of wave functions for r -> infinity. The change comes from the behaviour unique in the one-particle motion with low o

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-defici

Suppression of the molecular ultra-fast dissociation in bromomethane clusters.

We address the influence of clustering on the ultra-fast dissociation of bromomethane. Valence and core photo-electron spectroscopy, partial electron yield absorption, and resonant Auger spectroscopy have been used together with ab initio calculations to investigate the properties of the ultra-fast dissociation. The ratio of ultra-fast dissociation of molecules in clusters as compared to free mole

Adaptive strategies in nocturnally migrating insects and songbirds: contrasting responses to wind.

1. Animals that use flight as their mode of transportation must cope with the fact that their migration and orientation performance is strongly affected by the flow of the medium they are moving in, i.e. by the winds. Different strategies can be used to mitigate the negative effects and benefit from the positive effects of a moving flow. The strategies an animal can use will be constrained by the

Resolving the Enigma of the Mesoamerican Nephropathy: A Research Workshop Summary

The First International Research Workshop on Mesoamerican Nephropathy (MeN) met in Costa Rica in November 2012 to discuss how to establish the extent and degree of MeN, examine relevant causal hypotheses, and focus efforts to control or eliminate the disease burden. MeN describes a devastating epidemic of chronic kidney disease of unknown origin predominantly observed among young male sugarcane cu

Large area quasi-free standing monolayer graphene on 3C-SiC(111)

Large scale, homogeneous quasi-free standing monolayer graphene is obtained on cubic silicon carbide, i.e., the 3C-SiC(111) surface, which represents an appealing and cost effective platform for graphene growth. The quasi-free monolayer is produced by intercalation of hydrogen under the interfacial, (6 root 3 x 6 root 3)R30 degrees-reconstructed carbon layer. After intercalation, angle resolved ph

Bone mass following physical activity in young years: a mean 39-year prospective controlled study in men.

This is a study on exercise-associated bone mineral density (BMD) which in men is maintained three decades after cessation of sports. In this prospective controlled cohort study active athletes had a BMD Z-score of 1.0 and after 39 years 0.5 to 1.2 depending on the measured region), using the same single-photon absorptiometry device, dual X-ray absorptiometry (DXA), and peripheral computed tomogra