Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund’s adjuvant is commonly used to induce disease in autoimmune models, and the quality of the adjuvant/autoantigen emulsion is of critical importance in determining reproducibility. We have established an emulsification method using a standard homogenizer an

This thesis focuses on processing and electro-optical investigations of two- and three-terminal photodetectors based on large arrays of around three million n+-i-n+ InP nanowires with embedded InAsP quantum heterostructures for broadband detection. First, we investigated the optoelectronic behavior of two-terminal photodetectors under selective 980 nm excitation of the 20 axially embedded InAsP qu

Pretend play has been studied in great depth in the past four decades, yielding an increasingly rich body of evidence and conjectures about the evolutionary, cognitive, social and linguistic competence acquired by young children through make-believe activities. In the current work, we drew connections between symbolic play and early forms of infants’ humorous initiatives, such as clowning and teas

Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (KATP) channels is a key event in this process. However, KATP channel closure alone is not sufficient to induce β-cell electrical activity; activation of a depolarizing membrane current is also required. Here we examine the role of the mechanosensor ion channel PIEZO1 in this process. Yod

BACKGROUND: Data on unrecognized liver cirrhosis in patients with hepatocellular carcinoma (HCC) are derived mainly from cohorts with a risk of selection bias.OBJECTIVES: In a population-based cohort study we aimed to determine the proportion, characteristics, and prognosis of HCC in patients with unrecognized cirrhosis.METHODS: Using the Swedish quality register for liver cancer and other nationw

In Sweden there are a great number of neo-gothic churches built in brick masonryaround 1870-1910. They are constructed as massive masonry walls with façadebricks attached to a core of massive red bricks. In the majority of these churchesthere is a presence of sodium sulphate causing salt damages. The source of the salts is known to be the red masonry bricks and the damage occurs both internally an

Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part

Patients with acute coronary syndrome (ACS) are at risk for recurrent adverse events, and multiple reports suggest that this risk is increased in patients with concomitant diabetes mellitus (DM) and peripheral artery disease (PAD). The aim of this article was to investigate cardiovascular outcomes in patients with DM presenting with ACS, stratified by PAD status. Data were derived from 4 randomize

Background: As a widely distributed and aerial migratory bird, the Common Swift (Apus apus) flies over a wide geographic range in Eurasia and Africa during migration. Although some studies have revealed the migration routes and phenology of European populations, A. a. apus (from hereon the nominate apus), the route used by its East Asian counterpart A. a. pekinensis (from hereon pekinensis) remain

HaptiMap is a high profile FP7 project to enhance the use and accessibility of mobile maps and location based services on mobile devices, through the integration of the tactile, audio and visual senses to augment applications when in non-ideal, noisy or poor-visibility situations. It provides an adaptable toolkit to aid developers in including accessibility functionality into, multi-modal mobile a