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Development of Stable Long-term Electrode Tissue Interfaces for Recording and Stimulation

Summary: Brain Computer interfaces (BCIs) are stable inside the brain over long periods of time and that have minimal effects on the physiological conditions of the neural tissue. This chapter reviews the state-of-the-art of neural interfaces and the concepts behind recent research and development of biocompatible BCIs. It focuses on various tissue responses in the brain to an implanted foreign bo

Subsidies in aviation

Relatively little attention has been paid to the existence of subsidies in aviation. As the sector's importance for economic development is often highlighted, this paper seeks to provide a conceptual overview of the various forms of subsidies in aviation, as a contribution to a more holistic understanding of economic interrelationships. Based on a purposive sampling strategy, existing forms of sub

Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia

Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We hypothesized that renal expression of podocyte-specific proteins would be reflected in urinary extracellular vesicles (EVs) of podocyte origin and accompanied by increased urinary soluble nephrin levels (nephrinuria) in preeclampsia. We furth

The climate mitigation gap : Education and government recommendations miss the most effective individual actions

Current anthropogenic climate change is the result of greenhouse gas accumulation in the atmosphere, which records the aggregation of billions of individual decisions. Here we consider a broad range of individual lifestyle choices and calculate their potential to reduce greenhouse gas emissions in developed countries, based on 148 scenarios from 39 sources. We recommend four widely applicable high

Si measurements : SiOx on Si

We review the results of silicon measurements, which we have performed on suboxide SiOx formed on n and p type Si wafers with different surface textures. Localized vibrational modes through Raman and FTIR, light emission properties by photoluminescence (PL), energy critical points for optical transitions, excited state dynamics and non-linear electrical properties can be used as effective methods

Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves : A Swedish cohort study

Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillatio

Pharmacological treatment of oro-facial pain - health technology assessment including a systematic review with network meta-analysis

This health technology assessment evaluated the efficacy of pharmacological treatment in patients with oro-facial pain. Randomised controlled trials were included if they reported pharmacological treatment in patients ≥18 years with chronic (≥3 months) oro-facial pain. Patients were divided into subgroups: TMD-muscle [temporomandibular disorders (TMD) mainly associated with myalgia]; TMD-joint (TM

Nonlinear Air-Path Control of a Heavy-Duty Diesel Engine—A Receding Horizon Sliding Control Approach

Precise air-path control of heavy-duty diesel engines contributes to emission regulation and high engine efficiency. The air path with VGT and EGR system is highly nonlinear with non-minimum-phase-system properties. The authors present a nonlinear control design - Receding Horizon Sliding Control (RHSC) to solve the tracking problem of the air-path. This control method handles the nonlinear dynami

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations

To gain insight into miRNA regulation in metastasis formation, we used a metastasis cell line model that allows investigation of extravasation and colonization of circulating cancer cells to lungs in mice. Using global miRNA profiling, 28 miRNAs were found to exhibit significantly altered expression between isogenic metastasizing and non-metastasizing cancer cells, with miR-155 being the most diff

Well-being and perceptions of everyday activities among those who attend community-based day centres for people with mental illness in Sweden - Does an immigrant background make a difference?

Background: Community-based day centres (CBDCs) for people with mental illness are a common service for both people with an immigrant background and native Swedes. Aim: The aim was to compare CBDC attendees with an immigrant background with attendees who were native Swedes in terms of well-being and perceptions of everyday activities and investigate whether ethnic background could predict these fa

Citation metrics and Impact Factors fail as measures of scientific quality, in particular in taxonomy, and are biased by biological disciplin and by geographic and taxonomic factors

Based on the experience of the author and analyses of citation frequences of papers published in various biological journals, the use of citation counts and journal Impact Factors as a measure of scientific quality is discussed. It is concluded that citation frequency differ not only among biological sub-disciplines such as ecology and taxonomy, but also among taxonomic papers on highly similar toBased on my experience and analyses of citation frequencies of papers published in various biological journals, I discuss the use of citation counts and journal Impact Factors as measures of scientific quality. I conclude that citation frequency differs not only among biological sub-disciplines such as ecology and taxonomy, but also among taxonomic papers on highly similar topics, and that these l

Does glycosylation influence the experimental antithrombotic effect of a two-domain tissue factor pathway inhibitor?

We have earlier shown that both full-length and truncated glycosylated tissue factor pathway inhibitor (TFPI) lacking the third Kunitz domain and the c-terminal region has an antithrombotic effect comparable to low-molecular-weight heparin (LMWH) in an experimental venous thrombosis model. The aim of this study was to investigate whether a recombinant truncated non-glycosylated TFPI (117QTFPI1-161

Brain responses to morphologically complex words: an electrophysiological study on Swedish past tense forms

Dual system models postulate two distinct neural mechanisms for the processing of inflected words: irregular forms (e.g. ‘went’) are assumed to be directly accessed as whole word representations, whereas regularly inflected items (e.g. ‘played’) might undergo rule-based decomposition (Pinker & Ullman, 2002). Irregular verb stems incorrectly carrying a regular inflectional suffix have been repo

Protamine neutralization of intravenous and subcutaneous low-molecular-weight heparin (tinzaparin, Logiparin(TM)). An experimental investigation in healthy volunteers

The aim of the present study was to investigate whether tinzaparin sodium (a low-molecular-weight heparin (LMWH)) was fully and permanently neutralized in vivo in man by protamine sulphate (PS) after intravenous (i.v.) or subcutaneous (s.c.) injection. Fifty healthy adults equally divided in five age- and sex-matched groups were included. The groups received 50 IU unfractionated heparin (UH)/kg bo

Sub-100-nm gate-length scaling of vertical InAs/InGaAs nanowire MOSFETs on Si

We demonstrate a process to vary the gate-length of vertical MOSFETs on the same sample with high accuracy and high performance. Fabricated vertical InAs/InGaAs MOSFETs on Si have gate length ranging from 25 nm to 140 nm. The results shown are from single nanowire transistors as well as arrays with nanowires ranging from 80 to 500 nanowires. The devices show good yield and clear scaling trends. We