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Doxorubicin (DOX) is a cornerstone drug in the treatment of osteosarcoma. However, achieving sufficient concentration in the tumor tissue after systemic administration with few side effects has been a challenge. Even with the most advanced nanotechnology approaches, less than 5% of the total administered drug gets delivered to the target site. Alternatives to increase the local concentration of DO

This article studies autobiographical accounts of breast cancer, so called pathographies, analysing how the body and the illness are portrayed. The article has a special focus on the experiences of the lived body, relating it to the psychological concept resilience as well as to the sense of estrangement of the body in illness and the socially situated body. The focus of the study is two autobiogr

Human overexploitation of natural resources has placed conservation and management as one of the most pressing challenges in modern societies, especially in regards to highly vulnerable marine ecosystems. In this context, cryptic species are particularly challenging to conserve because they are hard to distinguish based on morphology alone, and thus it is often unclear how many species coexist in

Retinitis Pigmentosa represents a group of genetic disorders that cause progressive vision loss via degeneration of pho8toreceptors, but there is in principle no treatment available. For any therapy development, a deeper comprehension of the dis9ease-leading mechanism(s) at the molecular level is needed. Here we focused on the cGMP-PKG system, which has been suggested10 to be a driver in several m

Laser-driven proton acceleration is a growing field of interest in the high-power laser community. One of the big challenges related to the most routinely used laser-driven ion acceleration mechanism, Target-Normal Sheath Acceleration (TNSA), is to enhance the laser-to-proton energy transfer such as to maximize the proton kinetic energy and number. A way to achieve this is using nanostructured tar

Structured solid targets are widely investigated to increase the energy absorption of high-power laser pulses so as to achieve efficient ion acceleration. Here we report the first experimental study of the maximum energy of proton beams accelerated from sub-micrometric foils perforated with holes of nanometric size. By showing the lack of energy enhancement in comparison to standard flat foils, ou

In this post we share a methodological reflection about the possibility to evaluate possible drivers of environmental conflict by using remote sensing. If we define nature as green resources, for instance, it is possible to assess how vulnerable peace might be, against environmental changes occurring on the ground by using satellite data. Satellite data can then be used, in combination with fieldw

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficul

Fear needs dealing with. Fear demands to be abated, countered or turned into something else, contributing and curtailing how we ‘do’ being human beings. This special issue of the European Journal of Cultural Studies addresses fear within media and popular culture, adopting a cultural studies approach to fear in a variety of socio-cultural and political contexts. A cultural studies approach allows

Oppenheimer describes The Act of Killing as a ‘documentary about the imagination. We are documenting the ways we imagine ourselves, the ways we know ourselves’. This research analyses the documentary films The Act of Killing (Director Oppenheimer, co-directors Christine Cynn and anonymous 2012) and The Look of Silence (director Oppenheimer 2014), and the documentary imaginary. The research combine

Modern food production is spatially concentrated in global "breadbaskets". A major unresolved question is whether these peak production regions will shift poleward as the climate warms, allowing some recovery of potential climaterelated losses. While agricultural impacts studies to date have focused on currently cultivated land, the Global Gridded Crop Model Intercomparison Project (GGCMI) Phase 2

Konflikter mellan olika samhällsgrupper och människors fördomar har länge intresserat samhällsvetenskapliga forskare. Många har också sökt svar på frågan om vad som kan göras för att överbrygga och minska dessa klyftor, splittringar och fördomar. Denna avhandling relaterar till denna diskussion och forskningsprocessen har ägt rum i flera steg. Först har en experimentell praxis utvecklats för att mConflicts between different social groups and people's prejudices have interested social science researchers for a long time. Many have also sought answers to the question of what can be done to bridge and reduce these gaps, divisions and prejudices. This dissertation relates to these discussions and the research process has taken place in several stages. First, an experimental practice has been d