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Nonmotor fluctuations in Parkinson disease: Severity and correlation with motor complications.

OBJECTIVE: To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD). METHODS: The Multicenter NonMotor Fluctuations in PD cross-sectional study used clinical examination of 10 NMS (dysphagia, anxiety, depression, fatigue, excessive sweating, inner restlessness, pain, concentration/attention, dizziness, bladder urgenc

Production of raw starch-degrading enzyme by Aspergillus sp. and its use in conversion of inedible wild cassava flour to bioethanol.

The major bottlenecks in achieving competitive bioethanol fuel are the high cost of feedstock, energy and enzymes employed in pretreatment prior to fermentation. Lignocellulosic biomass has been proposed as an alternative feedstock, but because of its complexity, economic viability is yet to be realized. Therefore, research around non-conventional feedstocks and deployment of bioconversion approac

Memory tourism in a contested landscape : exploring identity discourses in Lviv, Ukraine

The study explores divergent representations and cultural identity in a historically contested landscape. The first form of representations includes politically amended place marketing. It is analysed how public discourse on a city’s development and regeneration articulate inscriptions of local authorities to pursue political-economic agendas. The second form of representations is diaspora’s imagi

Various regimens for prophylactic treatment of patients with haemophilia

Haemophilia prophylaxis is superior to on-demand treatment to prevent joint damage. High-dose prophylaxis' as used in Sweden is more effective in preventing arthropathy than an intermediate-dose regimen' (the Netherlands) and the Canadian tailored primary prophylaxis. Prophylaxis may reduce the risk of developing inhibitors. There is no difference in inhibitor risk between plasma derived and recom

Mesonic Low-Energy Constants

We review the status of the coupling constants of chiral Lagrangians in the meson sector, the so-called low-energy constants (LECs). We emphasize the chiral SU(2) and SU(3) Lagrangians for the strong interactions of light mesons and discuss the theoretical and experimental input for determining the corresponding LECs. In the two-flavor sector, we review the knowledge of the O(p(4)) LECs from both

Partial volume correction of brain perfusion estimates using the inherent signal data of time-resolved arterial spin labeling.

Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross-contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high-resolution T1 -weighted morphological image volume that is coreg

EPR assessment of protein sites for incorporation of Gd(III) MRI contrast labels.

We have engineered apolipoprotein A-I (apoA-I), a major protein constituent of high-density lipoprotein (HDL), to contain DOTA-chelated Gd(III) as an MRI contrast agent for the purpose of imaging reconstituted HDL (rHDL) biodistribution, metabolism and regulation in vivo. This protein contrast agent was obtained by attaching the thiol-reactive Gd[MTS-ADO3A] label at Cys residues replaced at four d

Activation of the contact system at the surface of Fusobacterium necrophorum: a possible virulence mechanism in Lemierre's syndrome.

Fusobacterium necrophorum causes Lemièrre's syndrome, a serious disease with septic thrombophlebitis of the internal jugular vein, pulmonary involvement and systemic inflammation. The contact system is a link between inflammation and coagulation and contact activation by the bacteria could therefore contribute to the abnormal coagulation and inflammation seen in patients with Lemièrre's syndrome.

Reading during the composition of multi-sentence texts : an eye-movement study

Writers composing multi-sentence texts have immediate access to a visual representation of what they have written. Little is known about the detail of writers’ eye movements within this text during production. We describe two experiments in which competent adult writers’ eye movements were tracked while performing short expository writing tasks. These are contrasted with conditions in which partic

Measurement of the WW plus WZ cross section and limits on anomalous triple gauge couplings using final states with one lepton, missing transverse momentum, and two jets with the ATLAS detector at root s=7 TeV

The production of a W boson decaying to ev or mu v in association with a W or Z boson decaying to two jets is studied using 4.6 fb(-1) of proton-proton collision data at root s = 7 TeV recorded with the ATLAS detector at the LHC. The combined WW + WZ cross section is measured with a significance of 3.4 sigma and is found to be 68 +/- 7 (stat.) +/- 19 (syst.) pb, in agreement with the Standard Mode

Do risk factors for schizophrenia predispose to emigration?

Objective: Increased incidence rates of schizophrenia in immigrants still lack a satisfactory explanation. The aim of this study was to examine the hypothesis that risk factors for schizophrenia also increase the risk of emigration to a foreign country. If valid, Danes emigrating from Denmark carry a higher predisposition to develop schizophrenia compared to Danes living in Denmark. Methods: Utili

On the Microlocal Properties of the Range of Systems of Principal Type

The purpose of this paper is to study microlocal conditions for inclusion relations between the ranges of square systems of pseudodifferential operators which fail to be locally solvable. The work is an extension of earlier results for the scalar case in this direction, where analogues of results by L. Hormander about inclusion relations between the ranges of first order differential operators wit

EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans.

Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performe

Proteolytic Activation Transforms Heparin Cofactor II into a Host Defense Molecule.

The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknown role for HCII in host defense. Proteolytic cleavage of the molecule induced a conformational change, thereby inducing endotoxin-binding and antimicr

The social world within reach: Intersubjective manifestations of action completion.

This is a study of the intersubjective recognizability of the “proper” accomplishment of children’s actions, and in particular of how the status of actions as properly completed is often actively made recognizable through speech and various modulations of bodily movement. In addition to analyzing how children do this in a number of cases, it is also argued that these manifestations of action compl

Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies.

Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating polymorphonuclear leukocytes (PMNs) to degranulate and produce reactive oxygen species (ROS). The aim of this study was to investigate if PMNs from AAV patients are more readily stimulated by ANCA compared with PMNs from healthy controls (HCs). Differences in ANCA character