Carbapenem resistance caused by metallo-β-lactamases is a serious global challenge that, if not tackled efficiently, is expected to lead to millions of deaths in the coming decades. Verona-integron encoded metallo-β-lactamase 2 (VIM-2) is a bacterial enzyme that has been reported from multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. As it hydroly

Adaptation to different ecological niches is considered one of the main drivers of species diversification, also in cryptic species complexes, notwithstanding their morphological stasis. We here review all the published information on ecological differentiation within cryptic species complexes within the phylum Rotifera. We found 177 instances of cryptic species identified genetically, published i

Distributed tracing plays a vital role in microservice infrastructure, and learning-based trace analysis has been utilized to detect anomalies within such systems. However, existing approaches for learning-based trace-based anomaly detection face certain limitations. Some assume that trace patterns can be learned solely from normal executions, while others depend on anomaly injection to generate l

Bulged-out nucleotides or internal loops are present in the stem-loop structures of several antisense RNAs. We have used the antisense/target RNA system (CopA/CopT) that controls the copy number of plasmid R1 to examine the possible biological function of bulged-out nucleotides. Two regions within the major stem-loop of the antisense RNA, CopA, carry bulged-out nucleotides. Base pairing in either

By harnessing the powers of polycrystalline materials an unprecedented, technologically-driven age has taken formover the last 100 years. The polycrystal is today, arguably, the most central building block for electronics, renewableenergy, transportation and medical equipment industries. This material class is the reason for the emergence of thepowerful microprocessors, semiconductors, memory chip

What should count as legitimate forms of reasoning in public deliberation is a contested issue. Democratic theorists have argued that storytelling may offer a more accessible form of deliberation for marginalised citizens than ‘rational argumentation’. We investigate the empirical support for this claim by examining Swedish citizens’ use of storytelling in written communication with the political

Accurately categorizing home furnishing items into interior design style groups plays a crucial role in delivering personalized recommendations that align with customers' design style preferences. However, manually labeling items by experts is a costly and resource-intensive task. To address this challenge, deep learning methods are used to automate the manual labeling of IKEA home furnishing

Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To study efficiently some of the potential undesirable effects associated with increasing APAP consumption (e.g., developmental disorders, drug-induced liver injury), there is a need to improve current APAP biomonitoring methods that are limit

This paper discusses a grounded theory study of women's experience of ICTs in the United Arab Emirates (UAE). We were particularly interested in whether their gender, and the society in which they live, affected that experience. We identify three themes, ICT Use, Gender Perspective and UAE Society which together constitute an emergent theory of Women's ICT experience in the UAE. We conclude by eng

Contemporary markets grapple with pressing challenges to secure socially and economically outcomes. Against this backdrop, market failures, notably those accentuated by sustainability and income inequality issues, have risen to prominence in competition law discourse, both doctrinally and in the realm of policymaking. This dynamic hints at an evolving paradigm: competition law might no longer be i

The basal and TRH (Thyrotropin-Releasing Hormone) stimulated TSH (Thyrotropin) and PRL (Prolactin) responses (incremental area; IA) to 200 micrograms TRH was studied in 13 pre- and 13 postmenopausal women of 60 years of age. Both groups consisted of healthy women, none had goiter and all were negative for thyroid autoantibodies. The serum levels of TSH, T3, T4 and SHBG (sex hormone-binding globuli

When two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized cryptic species of banded newt (genus Ommatotriton) are suspected to meet in parapatry in Anatolia, but a formal hybrid zone analysis has never been conducted. We sample populations throughout the range, with a focus on the supposed contact

The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G (IgG) antibodies in the hinge region resulting in Fc (fragment crystallizable) and F(ab')2 (fragment antigen-binding) fragments and protects the bacteria against phagocytic killing. Experiments with radiolabeled IdeS and flow cyt

We recently reported that female patients with hypopituitarism receiving controlled thyroid and steroid hormone substitution, but without GH replacement, had a more than 2-fold increase in cardiovascular mortality compared to the general population. In the present study we investigated the incidence of cardiovascular disease as well as the prevalence of cardiovascular risk factors in 33 females wi

Glacio-hydrological modeling is a key task for assessing the influence of snow and glaciers on water resources, essential for water resources management. The present study aims to enhance a conceptual hydrological model (namely Glacial Snow Melt (GSM)) by data-driven and swarm computing for enhancing the accuracy of rainfall runoff prediction. The proposed framework combines the conceptual hydrolo