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Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe : findings from the ERA Registry

Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du

Josephson effect in a Fibonacci quasicrystal

Quasiperiodicity has recently been proposed to enhance superconductivity and its proximity effect. Simultaneously, there has been significant experimental progress in the fabrication of quasiperiodic structures, including in reduced dimensions. Motivated by these developments, we use microscopic tight-binding theory to investigate the DC Josephson effect through a ballistic Fibonacci chain attache

Environmental sustainability from a decoupling point perspective

Combatting climate change is of global importance. The fact that all UN member nations have agreed on the sustainable development goals (SDGs) is testament to this. The manufacturing industry plays a crucial part in meeting these goals. However, if manufacturing firms are to improve in terms of sustainability, such efforts must be reconcilable with their ability to make profit. Hence, sustainabili

Bivalirudin vs Heparin Anticoagulation in STEMI : Confirmation of the BRIGHT-4 Results

Background: In the BRIGHT-4 (Bivalirudin With Prolonged Full-Dose Infusion During Primary PCI Versus Heparin Trial-4), anticoagulation with bivalirudin plus a 2- to 4-hour high-dose infusion after percutaneous coronary intervention (PCI) reduced all-cause mortality and bleeding without increasing reinfarction or stent thrombosis compared with heparin alone in patients with ST-segment elevation myo

International comparison and time trends of first kidne transplant recipient characteristics across Europe : an ERA Registry study

Background. The aim of this study was to provide an overview of age, sex and primary renal disease (PRD) distribution among first kidney transplant recipients across Europe. Method. The European Renal Association (ERA) Registry database was used to obtain data on patients aged 20 years or older receiving their first kidney transplant between 2010 and 2019 from 12 European countries. The numbers an

Identification of genetic fingerprint of type I interferon therapy in visceral metastases of melanoma

Malignant melanoma is a difficult-to-treat skin cancer with increasing incidence worldwide. Although type-I interferon (IFN) is no longer part of guidelines, several melanoma patients are treated with type-I interferon (IFN) at some point of the disease, potentially affecting its genetic progression. We run genome-wide copy number variation (CNV) analysis on previously type-I IFN-treated (n = 17)

Non-transitive better than relations and rational choice

This paper argues that decision problems and money-pump arguments should not be a deciding factor against accepting non-transitive better than relations. If the reasons to accept normative standpoints that entail a non-transitive better than relation are compelling enough, we ought to revise our decision method rather than the normative standpoints. The paper introduces the most common argument in

Predicting CO2 and CH4 fluxes and their seasonal variations in a subarctic wetland under two shared socioeconomic pathway climate scenarios

The Arctic is undergoing a shift toward a warmer and wetter climate. Recent experiments indicate that the carbon balance of subarctic wet tundra is sensitive to both summer warming and deeper snow. However, few studies have combined experimental data with process-oriented models to predict how the terrestrial carbon cycle will respond to future climate change. Here, we use CoupModel, a process-ori